Drug Transporter (DT) Information

General Information of DT
DT ID DTD0118
Gene Name SLC17A5
Protein Name Vesicular H(+)/Aspartate-glutamate cotransporter
Gene ID
26503
UniProt ID
Q9NRA2
TCDB ID
2.A.1.14.10
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6V4D_A

Identity:41.164%

Minimized Score:-1038.125 kcal/mol

Detail: Structure Info

Synonyms AST; H(+)/nitrate cotransporter; ISSD; Membrane glycoprotein HP59; NSD; SD; SIASD; SLC17A5; SLD; Sialin; Solute carrier family 17 member 5; H(+)/sialic acid cotransporter
DT Family Major Facilitator Superfamily (MFS)
Anion:Cation Symporter (ACS) Family
Tissue Specificity Found in fetal lung and small intestine, andat lower level in fetal skin and muscle. In the adult, detected inplacenta, kidney and pancreas. Abundant in the endothelial cellsof tumors from ovary, colon, breast and lung, but is not detectedin endothelial cells from the corresponding normal tissues.
Function This transporter mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. It also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
Endogenous Substrate(s) Sialic acid
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Vesicular H(+)/Aspartate-glutamate cotransporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Vesicular H(+)/Aspartate-glutamate cotransporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Vesicular H(+)/Aspartate-glutamate cotransporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Vesicular H(+)/Aspartate-glutamate cotransporter
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Vesicular H(+)/Aspartate-glutamate cotransporter
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Vesicular H(+)/Aspartate-glutamate cotransporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Vesicular H(+)/Aspartate-glutamate cotransporter
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Vesicular H(+)/Aspartate-glutamate cotransporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Vesicular H(+)/Aspartate-glutamate cotransporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
N-acetylaspartylglutamate
 Phase 4 Drug Info Vernal Keratoconjunctivitis 9A60.5 [1]
Nitrate
 Phase 4 Drug Info Stable angina BA40.1 [2]

Drug-DT Affinity Assessed by Cell Line

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
N-acetylaspartylglutamate Phase 4 Drug Info Proteoliposomes-Sialin Km =200 microM [1]
N-acetylaspartylglutamate Phase 4 Drug Info Proteoliposomes-Sialin Km =200 microM [1]
References
1 Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5). Biochem J. 2013 Aug 15;454(1):31-8.
2 Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13434-9.

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