Detail Information of Mutation-induced Spatial Variation

General Information of Drug Transporter (DT)
DT ID	DTD0118 Transporter Info
Gene Name	SLC17A5
Transporter Name	Vesicular H(+)/Aspartate-glutamate cotransporter
Gene ID	26503
UniProt ID	Q9NRA2
Mutation-induced Structural Variation (MSV) of This DT
Click to Save PDB File in TXT Format	PDB ID		8U3F
	Expression System		Homo sapiens
	Method		EM
	Resolution		3.31 Å
	Corresponding chain		A
	Mutation Site(s)		R176K		[1]
	Structure Details		Click to Show/Hide the Details
Modeling Method	EM
Publication year	2024
Click to Save PDB File in TXT Format	PDB ID		9AYB
	Expression System		Homo sapiens
	Method		EM
	Resolution		3.19 Å
	Corresponding chain		A
	Mutation Site(s)		S69A		[1]
	Structure Details		Click to Show/Hide the Details
Modeling Method	EM
Publication year	2024
Closely Related Crystal Structure of This MSV
PDB ID	Scanning Method	Resolution	Mutation Sites	Details	Ref
8U3F	EM	3.31 Å	R176K	Show Detail	[1]
Structure
Expression System	Homo sapiens
Corresponding chain	A
Sequence Length	2-495		Mutation	Yes
9AYB	EM	3.19 Å	S69A	Show Detail	[1]
Structure
Expression System	Homo sapiens
Corresponding chain	A
Sequence Length	2-495		Mutation	Yes
References
1	Structure and inhibition of the human lysosomal transporter Sialin. Nat Commun. 2024 May 23;15(1):4386.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.