Detail Information of Transcriptional Regulations
General Information of Drug Transporter (DT) | |||||
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DT ID | DTD0118 Transporter Info | ||||
Gene Name | SLC17A5 | ||||
Transporter Name | Vesicular H(+)/Aspartate-glutamate cotransporter | ||||
Gene ID | |||||
UniProt ID | |||||
Transcriptional Regulation of This DT (TSR) | ||||||
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Class1.1: Basic leucine zipper factors |
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CEBPA |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [1] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein alpha | Transcription Factor Info | ||||
Tissue |
Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
CEBPB |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [2] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein beta | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
CEBPD |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [3] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein delta | Transcription Factor Info | ||||
Tissue |
Aorta | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
CREB1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [4] | ||||
TF Protein Name |
Cyclic AMP-responsive element-binding protein 1 | Transcription Factor Info | ||||
Tissue |
Embryo; Liver; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
FOS |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [1] | ||||
TF Protein Name |
Protein c-Fos | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein c-Fos (FOS) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
JUN |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC17A5 gene in K562 cells | [5] | ||||
TF Protein Name |
Transcription factor Jun | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC17A5 gene in K562 cells, which leads to an affected expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
XBP1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [2] | ||||
TF Protein Name |
X-box-binding protein 1 | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
X-box-binding protein 1 (XBP1) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Class1.2: Basic helix-loop-helix factors |
Click to Show/Hide the Full List of 5 TF(s) Regulating This DT |
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AHR |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of SLC17A5 gene in breast cancer condition | [6] | ||||
TF Protein Name |
Aryl hydrocarbon receptor | Transcription Factor Info | ||||
Affected Drug/Substrate |
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) | |||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC17A5 gene in breast cancer condition, which leads to an increased expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
ARNT |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of SLC17A5 gene in breast cancer condition | [6] | ||||
TF Protein Name |
Aryl hydrocarbon receptor nuclear translocator | Transcription Factor Info | ||||
Affected Drug/Substrate |
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) | |||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC17A5 gene in breast cancer condition, which leads to an increased expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
ASCL1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [4] | ||||
TF Protein Name |
Achaete-scute homolog 1 | Transcription Factor Info | ||||
Tissue |
Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
LYL1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [3] | ||||
TF Protein Name |
Protein lyl-1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein lyl-1 (LYL1) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
MITF |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of SLC17A5 gene in melanoma condition | [7] | ||||
TF Protein Name |
Microphthalmia-associated transcription factor | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC17A5 gene in melanoma condition, which leads to an increased expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Class2.1: Nuclear receptors with C4 zinc fingers |
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HNF4A |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC17A5 gene in health condition | [8] | ||||
TF Protein Name |
Hepatocyte nuclear factor 4-alpha | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC17A5 gene in health condition, which leads to an affected expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Transcriptional Phenomenon2 |
Binding to SLC17A5 gene in health condition | [9] | ||||
TF Protein Name |
Hepatocyte nuclear factor 4-alpha | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC17A5 gene in health condition, which leads to an affected expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
PPARD |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Repression of SLC17A5 gene in myofibroblasts condition | [10] | ||||
TF Protein Name |
Peroxisome proliferator-activated receptor delta | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Down regulating | |||||
Detailed Description |
Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC17A5 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Class2.2: Other C4 zinc finger-type factors |
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GATA1 |
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Transcriptional Phenomenon1 |
Binding to SLC17A5 gene in megakaryocytes condition | [11] | ||||
TF Protein Name |
Erythroid transcription factor | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC17A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC17A5 gene | [4] | ||||
TF Protein Name |
Erythroid transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Erythroid transcription factor (GATA1) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
GATA2 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC17A5 gene in megakaryocytes condition | [11] | ||||
TF Protein Name |
Endothelial transcription factor GATA-2 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLC17A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC17A5 gene | [1] | ||||
TF Protein Name |
Endothelial transcription factor GATA-2 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Endothelial transcription factor GATA-2 (GATA2) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Class2.3: C2H2 zinc finger factors |
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BCL6 |
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Transcriptional Phenomenon1 |
Activation of SLC17A5 gene in health condition | [12] | ||||
TF Protein Name |
B-cell lymphoma 6 protein | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of SLC17A5 gene in health condition, which leads to an increased expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
CTCF |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [3] | ||||
TF Protein Name |
Transcriptional repressor CTCF | Transcription Factor Info | ||||
Tissue |
Brain | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor CTCF (CTCF) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
EGR1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC17A5 gene in erythroleukemia condition | [13] | ||||
TF Protein Name |
Early growth response protein 1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC17A5 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
MAZ |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [2] | ||||
TF Protein Name |
Myc-associated zinc finger protein | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Cervix; Liver; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myc-associated zinc finger protein (MAZ) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Class3.1: Homeo domain factors |
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PBX3 |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [4] | ||||
TF Protein Name |
Pre-B-cell leukemia transcription factor 3 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Class3.3: Fork head / winged helix factors |
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E2F1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [4] | ||||
TF Protein Name |
Transcription factor E2F1 | Transcription Factor Info | ||||
Tissue |
Mesenchymal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F1 (E2F1) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
FOXA1 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC17A5 gene in prostate carcinoma condition | [14] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-alpha | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC17A5 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC17A5 gene | [3] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-alpha | Transcription Factor Info | ||||
Tissue |
Breast; Embryo; Liver; Pancreatic ductal; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
FOXA2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [4] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-beta | Transcription Factor Info | ||||
Tissue |
Embryo; Liver; Lung; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Class3.5: Tryptophan cluster factors |
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ERG |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [1] | ||||
TF Protein Name |
Transcriptional regulator ERG | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional regulator ERG (ERG) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
ETS1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [2] | ||||
TF Protein Name |
Protein C-ets-1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone; Bone marrow; Kidney; Lung; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein C-ets-1 (ETS1) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
ETS2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [1] | ||||
TF Protein Name |
Protein C-ets-2 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein C-ets-2 (ETS2) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
FLI1 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC17A5 gene in megakaryocytes condition | [11] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC17A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC17A5 gene | [2] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Mesenchymal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
GABPA |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [3] | ||||
TF Protein Name |
GA-binding protein alpha chain | Transcription Factor Info | ||||
Tissue |
Brain; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
GA-binding protein alpha chain (GABPA) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
SPI1 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC17A5 gene in APL condition | [15] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC17A5 gene in acute promyelocytic leukemia (APL) condition, which leads to an affected expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC17A5 gene | [1] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Tissue |
Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Class4.1: High-mobility group domain factors |
Click to Show/Hide the Full List of 1 TF(s) Regulating This DT |
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SOX2 |
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Transcriptional Phenomenon1 |
Activation of SLC17A5 gene in colorectal cancer condition | [16] | ||||
TF Protein Name |
Transcription factor SOX-2 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC17A5 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Class6.4: Runt domain factors |
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RUNX1 |
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Transcriptional Phenomenon1 |
Binding to SLC17A5 gene in megakaryocytes condition | [11] | ||||
TF Protein Name |
Runt-related transcription factor 1 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC17A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
Class10.1: Other factors |
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GTF2B |
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Transcriptional Phenomenon1 |
Direct binding to SLC17A5 gene | [2] | ||||
TF Protein Name |
Transcription initiation factor IIB | Transcription Factor Info | ||||
Tissue |
Cervix; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription initiation factor IIB (GTF2B) can directly bind to the SLC17A5 gene, which in turn affects the expression or function of the drug transporter Vesicular H(+)/Aspartate-glutamate cotransporter. | |||||
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