General Information of Drug Transporter (DT)
DT ID	DTD0118 Transporter Info
Gene Name	SLC17A5
Transporter Name	Vesicular H(+)/Aspartate-glutamate cotransporter
Gene ID	26503
UniProt ID	Q9NRA2
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	6V4D_A		Identity	41.164%
Performance	Minimized Score	-1038.125 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	High
Ramachandran Plot
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	Ramz Z Score	-2.23 ±0.34
	Residues in Favored Region	452	Ramachandran favored	95.97%
	Number of Outliers	2	Ramachandran outliers	0.42%
Local Quality
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	QMEANBrane Score		0.8
AlphaFold Protein Structure Database	Q9NRA2 Click to jump to the details page
SWISS-MODEL Database	Q9NRA2 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
8DWI	EM	3.4 Å	Escherichia coli	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	495		Mutation	No
8U3D	EM	2.83 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A
Sequence Length	503		Mutation	No
8U3E	EM	3.19 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A
Sequence Length	503		Mutation	No
8U3F	EM	3.31 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A
Sequence Length	503		Mutation	Yes
8U3G	EM	3.42 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A
Sequence Length	503		Mutation	No
8U3H	EM	3.67 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A
Sequence Length	503		Mutation	No
9AYB	EM	3.19 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A
Sequence Length	503		Mutation	Yes
References
1	The molecular mechanism of sialic acid transport mediated by Sialin. Sci Adv. 2023;9(3):eade8346.
2	Structure and inhibition of the human lysosomal transporter Sialin. Nat Commun. 2024 May 23;15(1):4386.

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