Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0113 | ||||
| Gene Name | SLC16A9 | ||||
| Protein Name | Monocarboxylate transporter 9 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | C10orf36; MCT 9; MCT9; SLC16A9; Solute carrier family 16 member 9 | ||||
| DT Family | Major Facilitator Superfamily (MFS) | ||||
| Monocarboxylate Transporter (MCT) Family | |||||
| Function | This transporter is proton-linked monocarboxylate transporter,and it may catalyze the transport of monocarboxylates across the plasma membrane. | ||||
| Endogenous Substrate(s) | Monocarboxylates | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Monocarboxylate transporter 9 |
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(β) Cell Distribution Level of Monocarboxylate transporter 9 |
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(γ) Organelle Distribution Level of Monocarboxylate transporter 9 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Monocarboxylate transporter 9 |
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(γ) Transcriptional Regulation of Monocarboxylate transporter 9 |
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(δ) Epigenetic Regulation of Monocarboxylate transporter 9 |
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(ε) Exogenous Modulation of Monocarboxylate transporter 9 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Monocarboxylate transporter 9 |
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(β) Disease-specific Protein Abundances of Monocarboxylate transporter 9 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Approved Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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L-carnitine
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Approved | Drug Info | Nutritional deficiency | 5B7Z | [1] |
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Clinical Trial Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Uric acid
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Phase 2/3 | Drug Info | Acute ischemic stroke | 8B11 | [2] |
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Endogenous Metabolites (EMs) Handled by This DT |
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Endogenous Metabolites (EMs) |
Click to Show/Hide the Full List of EMs: 1 EMs in Total | ||||
| EM Name | PubChem CID | Detail | Experimental Material | Ref | |
| Acylcarnitine C5 | EM Info | Unclear experiment used for identifying this EM | [3] | ||
| References | |||||
| 1 | Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney. BMC Neurosci. 2016 Jul 1;17(1):43. | ||||
| 2 | Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. Hum Cell. 2013 Dec;26(4):133-6. | ||||
| 3 | Genome-wide association studies with metabolomics. Genome Med. 2012 Apr 30;4(4):34. | ||||
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