Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00172
|
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| Drug Name |
Uric acid
|
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| Synonyms |
urate
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| Drug Type |
Small molecular drug
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| Indication | Acute ischemic stroke [ICD11:8B11] | Phase 2/3 | [1] | |||
| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C5H4N4O3
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| Canonical SMILES |
C12=C(NC(=O)N1)NC(=O)NC2=O
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| InChI |
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)
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| InChIKey |
LEHOTFFKMJEONL-UHFFFAOYSA-N
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| CAS Number |
CAS 69-93-2
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| Pharmaceutical Properties | Molecular Weight | 168.11 | Topological Polar Surface Area | 99.3 | ||
| Heavy Atom Count | 12 | Rotatable Bond Count | 0 | |||
| Hydrogen Bond Donor Count | 4 | Hydrogen Bond Acceptor Count | 3 | |||
| XLogP |
-1.9
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| PubChem CID | ||||||
| PubChem SID |
103023909
,103209253
,104296981
,104667154
,10533245
,117647145
,118496658
,124361506
,124403853
,125537295
,15219467
,15321837
,24439524
,24900620
,24900634
,26736256
,26744389
,26744398
,26744402
,26744403
,3136963
,3273
,3657
,46392403
,46505972
,49703316
,49748665
,50061717
,50125767
,50126454
,53788127
,5428230
,57320794
,589184
,610605
,6169533
,70376
,78578511
,7891020
,8036878
,8144012
,8151010
,83616204
,841790
,85090304
,85164958
,87577749
,88828756
,92297983
,93578147
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| ChEBI ID |
CHEBI:17775
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | BCRP | Transporter Info | Breast cancer resistance protein | Substrate | [2] | |
| MCT9 | Transporter Info | Monocarboxylate transporter 9 | Substrate | [3] | ||
| OAT1 | Transporter Info | Organic anion transporter 1 | Substrate | [4] | ||
| OAT3 | Transporter Info | Organic anion transporter 3 | Substrate | [4] | ||
| OAT4 | Transporter Info | Organic anion transporter 4 | Substrate | [4] | ||
| URAT1 | Transporter Info | Urate anion exchanger 1 | Substrate | [5] | ||
| Drug-Transporter Activity Data | ||||||
| Drug-Transporter Activity Data | OAT1 | Transporter Info | Km =197.6 microM | Human embryonic kidney cells (HEK293)-OAT1 | [4] | |
| OAT1 | Transporter Info | Km =947 microM | Proximal tubule (S2) cells-OAT1 | [6] | ||
| OAT3 | Transporter Info | Km =380.3 microM | Human embryonic kidney cells (HEK293)-OAT3 | [4] | ||
| OAT4 | Transporter Info | Km =106 microM | Human embryonic kidney cells (HEK293)-OAT4 | [4] | ||
| URAT1 | Transporter Info | Km =357.6 microM | Oocytes-URAT1 | [5] | ||
| References | ||||||
| 1 | ClinicalTrials.gov (NCT00860366) Efficacy Study of Combined Treatment With Uric Acid and rtPA in Acute Ischemic Stroke | |||||
| 2 | Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. PLoS One. 2012;7(2):e30456. | |||||
| 3 | Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. Hum Cell. 2013 Dec;26(4):133-6. | |||||
| 4 | Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46. | |||||
| 5 | Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter. J Pharmacol Exp Ther. 2007 Jan;320(1):211-7. | |||||
| 6 | Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney Int. 2003 Jan;63(1):143-55. | |||||
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