| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0088 | ||||
| Gene Name | SLC12A7 | ||||
| Protein Name | Electroneutral potassium-chloride cotransporter 4 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6UKN_A Identity:91.043% Minimized Score:308.751 kcal/mol Detail: Structure Info |
||||
| Synonyms | K-Cl cotransporter 4; KCC4; SLC12A7; Solute carrier family 12 member 7 | ||||
| DT Family | Cation-Chloride Cotransporter (CCC) Family ; | ||||
| Tissue Specificity | Detected in muscle, brain, lung, heart andkidney. | ||||
| Function | This transporter medially conducts neutral potassium chloride co-transport. It is very important for the survival of cochlear outer hair cells and inner hair cells and the maintenance of Corti organs. It may be necessary for lateral chlorine (-) extrusion of kidney basement. | ||||
| Endogenous Substrate(s) | Potassium; Chloride | ||||
| Variability Data of This Drug Transporter (DT) | |||||
|
Regulatory Variability Data of This DT (VARIDT 4.0) |
|||||
|
(α) Tissue Distribution Level of Electroneutral potassium-chloride cotransporter 4 |
|||||
|
(β) Cell Distribution Level of Electroneutral potassium-chloride cotransporter 4 |
|||||
|
(γ) Organelle Distribution Level of Electroneutral potassium-chloride cotransporter 4 |
|||||
|
Regulatory Variability Data of This DT |
|||||
|
(β) Post-translational Modification of Electroneutral potassium-chloride cotransporter 4 |
|||||
|
(γ) Transcriptional Regulation of Electroneutral potassium-chloride cotransporter 4 |
|||||
|
(δ) Epigenetic Regulation of Electroneutral potassium-chloride cotransporter 4 |
|||||
|
(ε) Exogenous Modulation of Electroneutral potassium-chloride cotransporter 4 |
|||||
|
Structural Variability Data of This DT |
|||||
|
(β) Inter-species Structural Differences |
|||||
|
General Variability Data of This DT |
|||||
|
(α) Genetic Polymorphisms of Electroneutral potassium-chloride cotransporter 4 |
|||||
|
(β) Disease-specific Protein Abundances of Electroneutral potassium-chloride cotransporter 4 |
|||||
|
(γ) Species- and Tissue-specific DT Abundances |
|||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.