General Information of Drug Transporter (DT)
DT ID	DTD0088 Transporter Info
Gene Name	SLC12A7
Transporter Name	Electroneutral potassium-chloride cotransporter 4
Gene ID	10723
UniProt ID	Q9Y666
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	6UKN_A		Identity	91.043%
Performance	Minimized Score	308.751 kcal/mol
	Ramachandra Favored	Poor
	QMEANBrane Quality	Poor
Ramachandran Plot
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	Ramz Z Score	-3.08 ±0.23
	Residues in Favored Region	913	Ramachandran favored	84.46%
	Number of Outliers	41	Ramachandran outliers	3.79%
Local Quality
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	QMEANBrane Score		0.55
AlphaFold Protein Structure Database	Q9Y666 Click to jump to the details page
SWISS-MODEL Database	Q9Y666 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
7D99	EM	2.9 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A/B
Sequence Length	1113		Mutation	No
References
1	Structures and an activation mechanism of human potassium-chloride cotransporters. Sci Adv. 2020 Dec 11;6(50):eabc5883.

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