Drug Transporter (DT) Information

General Information of DT
DT ID DTD0062
Gene Name ABCC9
Protein Name Sulfonylurea receptor 2
Gene ID
10060
UniProt ID
O60706
TCDB ID
3.A.1.208.23
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:5YKE_B

Identity:67.317%

Minimized Score:-2706.765 kcal/mol

Detail: Structure Info

Synonyms ATP-binding cassette sub-family C member 9; ABCC9; SUR2; ABC37; CANTU; CMD1O; ATFB12
DT Family ATP-Binding Cassette (ABC) Superfamily
Drug Conjugate Transporter (DCT) Family (ABCC)
Function This transporter is subunit of ATP-sensitive potassium channels (KATP).
Endogenous Substrate(s) Sulfonylurea
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sulfonylurea receptor 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sulfonylurea receptor 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sulfonylurea receptor 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sulfonylurea receptor 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sulfonylurea receptor 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sulfonylurea receptor 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sulfonylurea receptor 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sulfonylurea receptor 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sulfonylurea receptor 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Tolbutamide
 Approved Drug Info Non insulin dependent diabetes 5A11 [1]
References
1 ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.