Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00104
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| Drug Name |
Tolbutamide
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| Synonyms |
1-Butyl-3-(4-methylphenylsulfonyl)urea; 1-Butyl-3-(p-methylphenylsulfonyl)urea; 1-Butyl-3-(p-tolylsulfonyl)urea; 1-Butyl-3-(para-tolylsulfonyl) urea; 1-Butyl-3-tosylurea; 1-butyl-3-(4-methylphenyl)sulfonylurea; 1-p-Toluenesulfonyl-3-butylurea; 3-(p-Tolyl-4-sulfonyl)-1-butylurea; 3-(p-tolylsulfonyl)-1-butylurea; 3-[p-Tolyl-4-sulfonyl]-1-butylurea; Aglicid; Apo-Tolbutamide; Apotex Brand of Tolbutamide; Arcosal; Arkozal; Artosin; Artozin; Aventis Brand of Tolbutamide; Beglucin; Berlin-Chemie Brand of Tolbutamide; BerlinChemie Brand of Tolbutamide; Butamid; Butamide; Butamide Brand of Tolbutamide; Butamidum; D 860; Diaben; Diabesan; Diabetamid; Diabetol; Diabuton; Diasulfon; Diaval; Dirastan; Dolipol; Drabet; Glyconon; HLS 831; Hoechst Brand of Tolbutamide; Ipoglicone; Mobenol; N-(4-Methylbenzenesulfonyl)-N'-butylurea; N-(4-Methylphenylsulfonyl)-N'-butylurea; N-(p-Tolylsulfonyl)-N'-butylcarbamide; N-(p-tolylsulfonyl)-N'-n-butylurea; N-4-(Methylbenzolsulfonyl)-n-butylurea; N-4-Methylbenzolsulfonyl-N-butylurea; N-Butyl-N'-(4-methylphenylsulfonyl)urea; N-Butyl-N'-(p-tolylsulfonyl)urea; N-Butyl-N'-p-toluenesulfonylurea; N-Butyl-N'-toluene-p-sulfonylurea; N-n-Butyl-N'-tosylurea; Novo-Butamide; Orabet; Oralin; Oramide; Orezan; Orinase; Orinase (TN); Orinaz; Oterben; Pfizer Brand of Tolbutamide; Pramidex; R.A.N. Brand of Tolbutamide; Rastinon; Restinon; Sk-tolbutamide; T 0891; TOLBUTAMIDE USP; Tarasina; Tol-Tab; Tolbet;Tolbusal; Tolbutamid; Tolbutamid R.A.N.; Tolbutamida; Tolbutamida [INN-Spanish]; Tolbutamide (JP15/USP/INN); Tolbutamide Aventis Brand; Tolbutamide Butamide Brand; Tolbutamide Hoechst Brand; Tolbutamide Pfizer Brand; Tolbutamide [INN:BAN:JAN]; Tolbutamidum; Tolbutamidum [INN-Latin]; Tolbutone; Toluina; Tolumid; Toluran; Toluvan; Tolylsulfonylbutylurea; U 2043; Valdecasas Brand of Tolbutamide; Willbutamide; Yamanouchi Brand of Tolbutamide
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| Drug Type |
Small molecular drug
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| Indication | Non insulin dependent diabetes [ICD11:5A11] | Approved | [1] | |||
| Therapeutic Class |
Hypoglycemic Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C12H18N2O3S
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| Canonical SMILES |
CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C
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| InChI |
InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
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| InChIKey |
JLRGJRBPOGGCBT-UHFFFAOYSA-N
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| CAS Number |
CAS 64-77-7
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| Pharmaceutical Properties | Molecular Weight | 270.35 | Topological Polar Surface Area | 83.6 | ||
| Heavy Atom Count | 18 | Rotatable Bond Count | 5 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 3 | |||
| XLogP |
2.3
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| PubChem CID | ||||||
| PubChem SID |
10321470
,10531694
,11111857
,11111858
,11120087
,11120575
,11121063
,11121572
,11122052
,11147170
,11335516
,11360755
,11362641
,11363341
,11364689
,11365203
,11365903
,11367251
,11367765
,11368465
,11369813
,11370553
,11370554
,11371678
,11372854
,11373366
,11373934
,11375413
,11375927
,11376627
,11377976
,11457019
,11461727
,11466218
,11467338
,11484736
,11485776
,11489026
,11490415
,11492173
,5658513
,640044
,7847446
,7980810
,8144417
,8149557
,8153385
,855782
,85591
,9357
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| ChEBI ID |
ChEBI:27999
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | SUR1 | Transporter Info | Sulfonylurea receptor 1 | Substrate | [2] | |
| SUR2 | Transporter Info | Sulfonylurea receptor 2 | Substrate | [2] | ||
| References | ||||||
| 1 | Tolbutamide was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18. | |||||
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