Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0062 Transporter Info
Gene Name ABCC9
Transporter Name Sulfonylurea receptor 2
Gene ID
10060
UniProt ID
O60706

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCC9 gene in breast cancer bone metastasis condition [1]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of ABCC9 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Sulfonylurea receptor 2.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        HIF1A 

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       Transcriptional Phenomenon1

 Activation of ABCC9 gene in heart failure condition [2]

TF Protein Name

 Hypoxia-inducible factor 1-alpha Transcription Factor Info

Studied Phenotype

 Heart failure [ICD11: BD10-BD1Z]

Tissue

 Right atrium

Related DT Changes

 Up regulating

Experimental Material

 human right atrial cell isolates

Detailed Description

 Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of ABCC9 gene in heart failure condition, which leads to an increased expression of the drug transporter Sulfonylurea receptor 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.3: C2H2 zinc finger factors

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        SALL4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCC9 gene in health condition [3]

TF Protein Name

 Sal-like protein 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Sal-like protein 4 (SALL4) has been reported to bind to the transcription of ABCC9 gene in health condition, which leads to an affected expression of the drug transporter Sulfonylurea receptor 2.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

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        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCC9 gene in MCF7 cells [4]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of ABCC9 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sulfonylurea receptor 2.

        FOXO1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of ABCC9 gene in heart failure condition [2]

TF Protein Name

 Forkhead box protein O1 Transcription Factor Info

Studied Phenotype

 Heart failure [ICD11: BD10-BD1Z]

Tissue

 Right atrium

Related DT Changes

 Up regulating

Experimental Material

 human right atrial cell isolates

Detailed Description

 Forkhead box protein O1 (FOXO1) has been reported to activate the transcription of ABCC9 gene in heart failure condition, which leads to an increased expression of the drug transporter Sulfonylurea receptor 2.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

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        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to ABCC9 gene in glioblastoma multiforme condition [5]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of ABCC9 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Sulfonylurea receptor 2.
References
1 Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2 Central venous hypoxemia is a determinant of human atrial ATP-sensitive potassium channel expression: evidence for a novel hypoxia-inducible factor 1alpha-Forkhead box class O signaling pathway. Hypertension. 2010 May;55(5):1186-92.
3 SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
4 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
5 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.

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