Drug Transporter (DT) Information

General Information of DT
DT ID DTD0056
Gene Name ABCC10
Protein Name Multidrug resistance-associated protein 7
Gene ID
89845
UniProt ID
Q5T3U5
TCDB ID
3.A.1.208.31
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:5UJ9_A

Identity:34.882%

Minimized Score:-2035.798 kcal/mol

Detail: Structure Info

Synonyms ATP-binding cassette sub-family C member 10; ABCC10; MRP7; SIMRP7
DT Family ATP-Binding Cassette (ABC) Superfamily
Drug Conjugate Transporter (DCT) Family (ABCC)
Tissue Specificity Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.
Function This ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.
Disease(s) Human immunodeficiency virus infection [ICD-11:1C62.Z]
Endogenous Substrate(s) Lipophilic anions
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Multidrug resistance-associated protein 7
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Multidrug resistance-associated protein 7
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Multidrug resistance-associated protein 7
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Multidrug resistance-associated protein 7
Microbiota Influence (MBI)

(β) Post-translational Modification of Multidrug resistance-associated protein 7
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Multidrug resistance-associated protein 7
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Multidrug resistance-associated protein 7
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Multidrug resistance-associated protein 7
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Multidrug resistance-associated protein 7
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Multidrug resistance-associated protein 7
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           4 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Docetaxel
 Approved Drug Info Lung cancer 2C25 [1]
Paclitaxel
 Approved Drug Info Breast cancer 2C60-2C6Z [1]
Tamoxifen
 Approved Drug Info Breast cancer 2C60-2C6Z [1]
Tenofovir
 Approved Drug Info Human immunodeficiency virus infection 1C62.Z [2]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Estradiol-17beta-glucuronide
5281887
EM Info Unclear experiment used for identifying this EM [3]

Drug-DT Affinity Assessed by Cell Line

 Approved Drug

 Click to Show/Hide the Full List of Drug:           3 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Tamoxifen Approved Drug Info LLC-PK1 cells-MRP7 Km =0.078 microM [1]
Tamoxifen Approved Drug Info LLC-PK1 cells-MRP7 Km =0.078 microM [1]
Tamoxifen Approved Drug Info LLC-PK1 cells-MRP7 Km =0.078 microM [1]
References
1 Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7). Cancer Res. 2012 Dec 15;72(24):6457-67.
2 Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction. J Infect Dis. 2011 Jul 1;204(1):145-53.
3 Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development. Curr Med Chem. 2008;15(20):1981-2039.

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