Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0056 Transporter Info
Gene Name	ABCC10
Transporter Name	Multidrug resistance-associated protein 7
Gene ID	89845
UniProt ID	Q5T3U5

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone marrow; Breast; Cervix; Colon; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[4]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[4]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC10 gene in K562 cells			[5]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor Jun (JUN) has been reported to bind to the transcription of ABCC10 gene in K562 cells, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 7.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[3]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[1]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Bone marrow; Brain; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[1]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[2]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[2]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Tissue	Coronary artery
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 21 (TCF21) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[3]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[4]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[4]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
HNF4A		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC10 gene in health condition			[6]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of ABCC10 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 7.
Transcriptional Phenomenon2	Direct binding to ABCC10 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Tissue	Colon; Intestine; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
NR1H3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC10 gene in atherosclerotic foam cells condition			[7]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCC10 gene in atherosclerotic foam cells condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 7.
Transcriptional Phenomenon2	Activation of ABCC10 gene in hypercholesterolemia condition			[8]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	Hypercholesterolemia [ICD11: 5C80.0]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Albino rats
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCC10 gene in hypercholesterolemia condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 7.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[4]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast; Epithelium; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
RXRA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[4]
TF Protein Name	Retinoic acid receptor RXR-alpha		Transcription Factor Info
Tissue	Blood; Brain; Colon; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-alpha (RXRA) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[4]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC10 gene in erythroleukemia condition			[9]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of ABCC10 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 7.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[2]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[2]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Embryo; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[3]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[3]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[1]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[1]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[2]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
TF Superclass3: Helix-turn-helix domains
Class3.2: Paired box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
PAX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[3]
TF Protein Name	Paired box protein Pax-5		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Paired box protein Pax-5 (PAX5) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[1]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
E2F8		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[2]
TF Protein Name	Transcription factor E2F8		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F8 (E2F8) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ELK3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC10 gene in hypoxia condition			[10]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of ABCC10 gene in hypoxia condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 7.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[2]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
ETV1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[3]
TF Protein Name	ETS translocation variant 1		Transcription Factor Info
Tissue	GastroIntestine tract; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS translocation variant 1 (ETV1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
FLI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC10 gene in megakaryocytes condition			[11]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of ABCC10 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 7.
Transcriptional Phenomenon2	Direct binding to ABCC10 gene			[4]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[1]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Liver; Lung; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[4]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[1]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
SPI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC10 gene in HL60 condition			[12]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of ABCC10 gene in HL60 condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 7.
Transcriptional Phenomenon2	Direct binding to ABCC10 gene			[4]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[2]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[2]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[1]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Tissue	Epithelium
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Tumor protein 63 (TP63) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC10 gene in megakaryocytes condition			[11]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of ABCC10 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 7.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC10 gene			[3]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the ABCC10 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 7.

References
1	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-252. (ID:ENSG00000124574)
5	c-Jun binding site identification in K562 cells. J Genet Genomics. 2011;38(6):235-42.
6	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
7	Genome-wide analysis of LXRa activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res. 2013;41(6):3518-31.
8	Effect of activation of liver X receptor alpha on cardiac & hepatic ABCC10 and SLC17A5 drug transporters in hypercholesterolemic rat model. Biochem Biophys Res Commun. 2022 Jun 25;610:133-139.
9	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
10	The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PLoS One. 2014;9(11):e113050.
11	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
12	Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.

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Detail Information of Transcriptional Regulations

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