Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0056 Transporter Info
Gene Name ABCC10
Transporter Name Multidrug resistance-associated protein 7
Gene ID
89845
UniProt ID
Q5T3U5
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Cyclosporine results in decreased expression of ABCC10 mRNA [19]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Valproic Acid affects the expression of ABCC10 mRNA [5]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 ABCC10 protein results in decreased susceptibility to Paclitaxel [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Imatinib Mesylate inhibits the reaction ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 Imatinib Mesylate inhibits the reaction ABCC10 protein results in decreased susceptibility to Paclitaxel [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 nilotinib inhibits the reaction ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 nilotinib inhibits the reaction ABCC10 protein results in decreased susceptibility to Paclitaxel [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation7

 Paclitaxel results in increased expression of ABCC10 mRNA [25]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Doxorubicin results in decreased expression of ABCC10 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  2-Acetylaminofluorene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-Acetylaminofluorene results in increased expression of ABCC10 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

  aristolochic acid I

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aristolochic acid I results in increased expression of ABCC10 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  Asbestos, Crocidolite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Asbestos, Crocidolite results in decreased expression of ABCC10 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  Docetaxel

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Docetaxel results in decreased susceptibility to Docetaxel which results in decreased expression of ABCC10 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  epigallocatechin gallate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of ABCC10 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

  Imatinib Mesylate

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Imatinib Mesylate inhibits the reaction ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Imatinib Mesylate inhibits the reaction ABCC10 protein results in decreased susceptibility to Paclitaxel [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Imatinib Mesylate inhibits the reaction ABCC10 protein results in decreased susceptibility to Vincristine [23]

Regulation Mechanism

 Transcription Factor Info

  Methyl Methanesulfonate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methyl Methanesulfonate results in increased expression of ABCC10 mRNA [24]

Regulation Mechanism

 Transcription Factor Info

  nilotinib

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 nilotinib inhibits the reaction ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 nilotinib inhibits the reaction ABCC10 protein results in decreased susceptibility to Paclitaxel [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 nilotinib inhibits the reaction ABCC10 protein results in decreased susceptibility to Vincristine [23]

Regulation Mechanism

 Transcription Factor Info

  N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ABCC10 mRNA [2]

Regulation Mechanism

 Transcription Factor Info

  potassium chromate(VI)

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of ABCC10 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 potassium chromate(VI) results in decreased expression of ABCC10 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in increased abundance of Arsenic which results in decreased expression of ABCC10 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  Tetrachlorodibenzodioxin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tetrachlorodibenzodioxin results in increased expression of ABCC10 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  trichostatin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 trichostatin A results in increased expression of ABCC10 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

  Vincristine

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ABCC10 protein results in decreased susceptibility to Vincristine [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Imatinib Mesylate inhibits the reaction ABCC10 protein results in decreased susceptibility to Vincristine [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 nilotinib inhibits the reaction ABCC10 protein results in decreased susceptibility to Vincristine [23]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Cyclosporine

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine inhibits the transportation of 17-estradiol-(17--d-glucuronide) by ABCC10 [1]

Affected Drug/Substrate

 17-estradiol-(17--d-glucuronide) Modulation Type Inhibition

Cell System

 Human embryonic kidney 293 cells (HEK293)-MRP7

  Estradiol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Estradiol inhibits the transportation of Estradiol-17beta-glucuronide by ABCC10 [1]

Affected Drug/Substrate

 Estradiol-17beta-glucuronide Modulation Type Inhibition

Cell System

 Human embryonic kidney 293 cells (HEK293)-MRP7

  Ethinyl Estradiol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ethinyl estradiol inhibits the transportation of Estradiol-17beta-glucuronide by ABCC10 [1]

Affected Drug/Substrate

 Estradiol-17beta-glucuronide Modulation Type Inhibition

Cell System

 Human embryonic kidney 293 cells (HEK293)-MRP7

  Etoposide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Etoposide inhibits the transportation of Estradiol-17beta-glucuronide by ABCC10 [1]

Affected Drug/Substrate

 Estradiol-17beta-glucuronide Modulation Type Inhibition

Cell System

 Human embryonic kidney 293 cells (HEK293)-MRP7

  Valproic Acid

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid increases the expression of ABCC10 [3]

  Zidovudine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zidovudine increases the expression of ABCC10 [4]

  Carbamazepine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Carbamazepine affects the expression of ABCC10 [5]

  Rifampin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Rifampin increases the expression of ABCC10 [6]

  Sunitinib

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sunitinib increases the expression of ABCC10 [7]

  Paclitaxel

            8 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Paclitaxel induces the activity of ABCC10 [8]

  Sulfinpyrazone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sulfinpyrazone inhibits the activity of ABCC10 [8]

  Doxorubicin

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Doxorubicin induces the activity of ABCC10 [9]

Drug Marketed but not Approved by US FDA

  Zinc Sulfate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zinc Sulfate increases the expression of ABCC10 [2]

Drug in Phase 1 Trial

  Trichostatin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Trichostatin A increases the expression of ABCC10 [10]

Drug in Preclinical Test

  (+)-JQ1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 (+)-JQ1 increases the expression of ABCC10 [12]

Natural Product

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution inhibits the expression of ABCC10 [15]

Traditional Medicine

  Jinfukang

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Jinfukang increases the expression of ABCC10 [13]

Environmental toxicant

  Polychlorinated dibenzodioxin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Polychlorinated dibenzodioxin increases the expression of ABCC10 [11]

Acute Toxic Substance

  Acrylamide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrylamide inhibits the expression of ABCC10 [14]

Carcinogen

  2-acetylaminofluorene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-acetylaminofluorene increases the expression of ABCC10 [10]

  Arsenic

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in increased abundance of Arsenic which results in decreased expression of ABCC10 mRNA [17]

Regulation Mechanism

 Transcription Factor Info
References
1 Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8.
2 A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6952-7.
3 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
4 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.
5 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
6 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
7 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
8 MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer. Mol Cancer Ther. 2008 May;7(5):1150-5.
9 Human ATP-binding cassette transporter ABCC10: expression profile and p53-dependent upregulation. J Exp Ther Oncol. 2004 Oct;4(3):239-46.
10 Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. J Biomed Sci. 2003 Jan-Feb;10(1):98-110.
11 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
12 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
13 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
14 Acrylamide exposure represses neuronal differentiation, induces cell apoptosis and promotes tau hyperphosphorylation in hESC-derived 3D cerebral organoids. Food Chem Toxicol. 2020 Oct;144:111643.
15 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
16 Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
17 Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells. Toxicol Sci. 2025;203(2):216-226.
18 Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells. Hum Mol Genet. 2015;24(5):1374-89.
19 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
20 L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18.
21 Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
22 Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
23 Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10). PLoS One. 2009;4(10):e7520.
24 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
25 Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68.

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