Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0522 Transporter Info
Gene Name CACNB4
Transporter Name Voltage-dependent L-type calcium channel beta-4
Gene ID
785
UniProt ID
O00305

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        JUNB 

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       Transcriptional Phenomenon1

 Direct binding to CACNB4 gene [1]

TF Protein Name

 Transcription factor JunB Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunB (JUNB) can directly bind to the CACNB4 gene, which in turn affects the expression or function of the drug transporter Voltage-dependent L-type calcium channel beta-4.

      Class1.2: Basic helix-loop-helix factors

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        TCF4 

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       Transcriptional Phenomenon1

 Binding to CACNB4 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of CACNB4 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        HNF4A 

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       Transcriptional Phenomenon1

 Binding to CACNB4 gene in health condition [3]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of CACNB4 gene in health condition, which leads to an affected expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.

        PPARD 

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       Transcriptional Phenomenon1

 Repression of CACNB4 gene in myofibroblasts condition [4]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of CACNB4 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

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       Transcriptional Phenomenon1

 Binding to CACNB4 gene in erythroleukemia condition [5]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of CACNB4 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.

        WT1 

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       Transcriptional Phenomenon1

 Activation of CACNB4 gene in podocyte condition [6]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of CACNB4 gene in podocyte condition, which leads to an increased expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNB4 gene [7]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the CACNB4 gene, which in turn affects the expression or function of the drug transporter Voltage-dependent L-type calcium channel beta-4.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        PBX1 

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       Transcriptional Phenomenon1

 Activation of CACNB4 gene in ovarian cancer condition [8]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of CACNB4 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.

      Class3.3: Fork head / winged helix factors

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        FOXA2 

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       Transcriptional Phenomenon1

 Binding to CACNB4 gene [3]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of CACNB4 gene in . condition, which leads to a affected expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.

      Class3.5: Tryptophan cluster factors

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        FLI1 

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       Transcriptional Phenomenon1

 Binding to CACNB4 gene in megakaryocytes condition [9]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of CACNB4 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.

       Transcriptional Phenomenon2

 Direct binding to CACNB4 gene [10]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the CACNB4 gene, which in turn affects the expression or function of the drug transporter Voltage-dependent L-type calcium channel beta-4.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to CACNB4 gene [11]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the CACNB4 gene, which in turn affects the expression or function of the drug transporter Voltage-dependent L-type calcium channel beta-4.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

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        STAT3 

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       Transcriptional Phenomenon1

 Activation of CACNB4 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of CACNB4 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.

      Class6.3: p53 domain factors

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        TP63 

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       Transcriptional Phenomenon1

 Binding to CACNB4 gene in health condition [12]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of CACNB4 gene in health condition, which leads to an affected expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of CACNB4 gene in epithelial ovarian cancer condition [13]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of CACNB4 gene in epithelial ovarian cancer condition, which leads to an increased expression of the drug transporter Voltage-dependent L-type calcium channel beta-4.
References
1 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-420. (ID:ENSG00000182389)
2 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
3 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
4 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
5 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
6 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
7 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
8 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
9 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
10 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
11 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
12 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
13 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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