| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0522 | ||||
| Gene Name | CACNB4 | ||||
| Protein Name | Voltage-dependent L-type calcium channel beta-4 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:1VYV_A Identity:96.657% Minimized Score:-1004.215 kcal/mol Detail: Structure Info |
||||
| Synonyms | CAB4; CACNB4; CACNLB4; Calcium channel voltage-dependent subunit beta 4; EA5; EIG9; EJM; EJM4; EJM6; Voltage-dependent L-type calcium channel subunit beta-4 | ||||
| DT Family | Ca(2+) Channel Auxiliary Subunit Beta Types 1-4 (CCA-Beta) Family ; | ||||
| Tissue Specificity | Expressed predominantly in the cerebellum andkidney. | ||||
| Function | The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. | ||||
| Endogenous Substrate(s) | Ca2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
|
Regulatory Variability Data of This DT (VARIDT 4.0) |
|||||
|
(α) Tissue Distribution Level of Voltage-dependent L-type calcium channel beta-4 |
|||||
|
(β) Cell Distribution Level of Voltage-dependent L-type calcium channel beta-4 |
|||||
|
(γ) Organelle Distribution Level of Voltage-dependent L-type calcium channel beta-4 |
|||||
|
Regulatory Variability Data of This DT |
|||||
|
(β) Post-translational Modification of Voltage-dependent L-type calcium channel beta-4 |
|||||
|
(γ) Transcriptional Regulation of Voltage-dependent L-type calcium channel beta-4 |
|||||
|
(δ) Epigenetic Regulation of Voltage-dependent L-type calcium channel beta-4 |
|||||
|
(ε) Exogenous Modulation of Voltage-dependent L-type calcium channel beta-4 |
|||||
|
Structural Variability Data of This DT |
|||||
|
(β) Inter-species Structural Differences |
|||||
|
General Variability Data of This DT |
|||||
|
(α) Genetic Polymorphisms of Voltage-dependent L-type calcium channel beta-4 |
|||||
|
(β) Disease-specific Protein Abundances of Voltage-dependent L-type calcium channel beta-4 |
|||||
|
(γ) Species- and Tissue-specific DT Abundances |
|||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.