Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0510 Transporter Info
Gene Name KCNH2
Transporter Name Voltage-gated potassium channel Kv11.1
Gene ID
3757
UniProt ID
Q12809

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [1]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Embryo; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        BHLHE40 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [2]

TF Protein Name

 Class E basic helix-loop-helix protein 40 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [3]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        TCF4 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of KCNH2 gene in glioblastoma multiforme condition [4]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of KCNH2 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Voltage-gated potassium channel Kv11.1.

       Transcriptional Phenomenon2

 Direct binding to KCNH2 gene [5]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor 4 (TCF4) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        TFAP4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [1]

TF Protein Name

 Transcription factor AP-4 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-4 (TFAP4) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [3]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to KCNH2 gene in prostate cancer condition [6]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of KCNH2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [1]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        PPARD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of KCNH2 gene in myofibroblasts condition [7]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of KCNH2 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Voltage-gated potassium channel Kv11.1.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 3 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to KCNH2 gene in health condition [8]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of KCNH2 gene in health condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

       Transcriptional Phenomenon2

 Binding to KCNH2 gene in megakaryocytes condition [9]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of KCNH2 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

       Transcriptional Phenomenon3

 Direct binding to KCNH2 gene [2]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to KCNH2 gene in hematopoiesis condition [8]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of KCNH2 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 11 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [5]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        CTCFL 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [2]

TF Protein Name

 Transcriptional repressor CTCFL Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCFL (CTCFL) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to KCNH2 gene in erythroleukemia condition [10]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of KCNH2 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [3]

TF Protein Name

 Krueppel-like factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 1 (KLF1) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [3]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        SALL4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to KCNH2 gene in health condition [11]

TF Protein Name

 Sal-like protein 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Sal-like protein 4 (SALL4) has been reported to bind to the transcription of KCNH2 gene in health condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

        SP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of KCNH2 gene in cancer condition [12]

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor Sp1 (SP1) has been reported to activate the transcription of KCNH2 gene in cancer condition, which leads to an increased expression of the drug transporter Voltage-gated potassium channel Kv11.1.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of KCNH2 gene in podocyte condition [13]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of KCNH2 gene in podocyte condition, which leads to an increased expression of the drug transporter Voltage-gated potassium channel Kv11.1.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [5]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Bone marrow; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [2]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

      Class2.9: C2CH THAP-type zinc finger factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        THAP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [5]

TF Protein Name

 THAP domain-containing protein 1 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 THAP domain-containing protein 1 (THAP1) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [3]

TF Protein Name

 Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        PBX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [1]

TF Protein Name

 Pre-B-cell leukemia transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        ZEB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [1]

TF Protein Name

 Zinc finger E-box-binding homeobox 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [2]

TF Protein Name

 Transcription factor E2F6 Transcription Factor Info

Tissue

 Bone marrow; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F6 (E2F6) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        FOXA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to KCNH2 gene in prostate carcinoma condition [14]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of KCNH2 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

       Transcriptional Phenomenon2

 Binding to KCNH2 gene in prostate cancer condition [15]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of KCNH2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of KCNH2 gene in embryonic stem cell condition [16]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of KCNH2 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Voltage-gated potassium channel Kv11.1.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [5]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Bone marrow; Liver; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [3]

TF Protein Name

 Transcriptional activator Myb Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional activator Myb (MYB) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [5]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        KDM5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [2]

TF Protein Name

 Lysine-specific demethylase 5B Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Lysine-specific demethylase 5B (KDM5B) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.2: Heteromeric CCAAT-binding factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NFYA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [2]

TF Protein Name

 Nuclear transcription factor Y subunit alpha Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        NFYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [3]

TF Protein Name

 Nuclear transcription factor Y subunit beta Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear transcription factor Y subunit beta (NFYB) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to KCNH2 gene in epithelial to mesenchymal transition condition [17]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of KCNH2 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

       Transcriptional Phenomenon2

 Binding to KCNH2 gene in health condition [18]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of KCNH2 gene in health condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to KCNH2 gene in megakaryocytes condition [9]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of KCNH2 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NFIC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [5]

TF Protein Name

 Nuclear factor 1 C-type Transcription Factor Info

Tissue

 Brain; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear factor 1 C-type (NFIC) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.

        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to KCNH2 gene in HaCaT keratinocytes condition [19]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of KCNH2 gene in HaCaT keratinocytes condition, which leads to an affected expression of the drug transporter Voltage-gated potassium channel Kv11.1.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.1: Other factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SETDB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to KCNH2 gene [1]

TF Protein Name

 Histone-lysine N-methyltransferase SETDB1 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Histone-lysine N-methyltransferase SETDB1 (SETDB1) can directly bind to the KCNH2 gene, which in turn affects the expression or function of the drug transporter Voltage-gated potassium channel Kv11.1.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-150. (ID:ENSG00000055118)
4 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
5 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
7 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
8 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
9 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
10 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
11 SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
12 Overexpression HERG K(+) channel gene mediates cell-growth signals on activation of oncoproteins SP1 and NF-kappaB and inactivation of tumor suppressor Nkx3.1. J Cell Physiol. 2007;212(1):137-47.
13 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
14 SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
15 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
16 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
17 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
18 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
19 Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Mol Cell Biol. 2009;29(1):172-86.

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