Crystal Structure
Crystallisation Method:EM
Corresponding Chain:A
Sequence Length:1-1159
Detail: Struture Info
Drug Transporter (DT) Information
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| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0510 | ||||
| Gene Name | KCNH2 | ||||
| Protein Name | Voltage-gated potassium channel Kv11.1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Crystal Structure Crystallisation Method:EM Corresponding Chain:A Sequence Length:1-1159 Detail: Struture Info |
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| Synonyms | ERG; ERG-1; ERG1; Eag homolog; Eag-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go-related protein 1; H-ERG; HERG; KCNH2; Kv11.1; LQT2; SQT1; Potassium voltage-gated channel subfamily H member 2; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1 | ||||
| DT Family | Voltage-Gated Ion Channel (VIC) Superfamily ; | ||||
| Tissue Specificity | Highly expressed in heart and brain. IsoformsUSO are frequently overexpressed in cancer cells. | ||||
| Function | This transporter mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. | ||||
| Endogenous Substrate(s) | Potassium ions | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-gated potassium channel Kv11.1 |
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(β) Cell Distribution Level of Voltage-gated potassium channel Kv11.1 |
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(γ) Organelle Distribution Level of Voltage-gated potassium channel Kv11.1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Voltage-gated potassium channel Kv11.1 |
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(γ) Transcriptional Regulation of Voltage-gated potassium channel Kv11.1 |
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(δ) Epigenetic Regulation of Voltage-gated potassium channel Kv11.1 |
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(ε) Exogenous Modulation of Voltage-gated potassium channel Kv11.1 |
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Structural Variability Data of This DT |
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(α) Mutation-induced Structural Variation |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-gated potassium channel Kv11.1 |
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(β) Disease-specific Protein Abundances of Voltage-gated potassium channel Kv11.1 |
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(γ) Species- and Tissue-specific DT Abundances |
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If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.