Detail Information of Exogenous Modulation
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0510 Transporter Info | ||||
| Gene Name | KCNH2 | ||||
| Transporter Name | Voltage-gated potassium channel Kv11.1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM) | |||||
|---|---|---|---|---|---|
Mycotoxins |
|||||
Aflatoxin B1 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Aflatoxin B1 results in decreased methylation of KCNH2 intron | [126] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
aflatoxin B2 |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
aflatoxin B2 results in increased methylation of KCNH2 intron | [126] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
aflatoxin B2 results in increased methylation of KCNH2 polyA tail | [126] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Pesticide/Insecticide |
|||||
DDT |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
DDT results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Approved Drug |
|||||
Maraviroc |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Maraviroc inhibits the transportation of Dofetilide by KCNH2 | [4] | |||
Affected Drug/Substrate |
Dofetilide | Modulation Type | Inhibition | ||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
DT Modulation2 |
Maraviroc inhibits the activity of KCNH2 | [5] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Pimozide |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pimozide inhibits the activity of KCNH2 | [6] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Thioridazine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Thioridazine inhibits the activity of KCNH2 | [6] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Bepridil |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bepridil inhibits the activity of KCNH2 | [6], [7] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Haloperidol |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Haloperidol inhibits the activity of KCNH2 | [6], [8] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Dofetilide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dofetilide inhibits the activity of KCNH2 | [7] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Clozapine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clozapine inhibits the activity of KCNH2 | [7], [8], [9] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Risperidone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Risperidone inhibits the activity of KCNH2 | [8] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Aripiprazole |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Aripiprazole inhibits the activity of KCNH2 | [8], [9] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Olanzapine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Olanzapine inhibits the activity of KCNH2 | [8], [9] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Mizolastine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Mizolastine inhibits the activity of KCNH2 | [10] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Fexofenadine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fexofenadine inhibits the activity of KCNH2 | [2] | |||
Erythromycin |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Erythromycin inhibits the activity of KCNH2 | [11], [12] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Quinine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Quinine inhibits the activity of KCNH2 | [13] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Rofecoxib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rofecoxib inhibits the activity of KCNH2 | [13] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Tegaserod |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tegaserod inhibits the activity of KCNH2 | [14], [15] | |||
Cell System |
Chinese hamster ovary (CHO) cells-KCNH2 | ||||
Levofloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Levofloxacin inhibits the activity of KCNH2 | [16] | |||
Cell System |
Chinese hamster ovary (CHO) cells-KCNH2 | ||||
Moxifloxacin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Moxifloxacin inhibits the activity of KCNH2 | [16] | |||
Cell System |
Chinese hamster ovary (CHO) cells-KCNH2 | ||||
Chloroquine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chloroquine inhibits the activity of KCNH2 | [17] | |||
Cell System |
Chinese hamster ovary (CHO) cells-KCNH2 | ||||
Halofantrine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Halofantrine inhibits the activity of KCNH2 | [17] | |||
Cell System |
Chinese hamster ovary (CHO) cells-KCNH2 | ||||
Cisapride |
7 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cisapride inhibits the activity of KCNH2 | [18] | |||
Cell System |
Chinese hamster ovary (CHO) cells-KCNH2 | ||||
Pentobarbital |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pentobarbital inhibits the activity of KCNH2 | [32] | |||
Probucol |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Probucol inhibits the activity of KCNH2 | [33] | |||
Dronedarone |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dronedarone inhibits the activity of KCNH2 | [34] | |||
Metoclopramide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Metoclopramide inhibits the activity of KCNH2 | [35] | |||
Gabapentin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Gabapentin inhibits the activity of KCNH2 | [36] | |||
Lamotrigine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Lamotrigine inhibits the activity of KCNH2 | [36] | |||
Topiramate |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Topiramate inhibits the activity of KCNH2 | [36] | |||
Carmustine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Carmustine inhibits the expression of KCNH2 | [37] | |||
Lovastatin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Lovastatin affects the activity of KCNH2 | [38] | |||
Metoprolol |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Metoprolol inhibits the activity of KCNH2 | [39] | |||
Mesoridazine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Mesoridazine inhibits the activity of KCNH2 | [40] | |||
Dipyridamole |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dipyridamole inhibits the activity of KCNH2 | [41] | |||
Ketoconazole |
12 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ketoconazole inhibits the activity of KCNH2 | [42] | |||
Arsenic |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Arsenic affects the expression of KCNH2 | [43] | |||
Codeine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Codeine inhibits the activity of KCNH2 | [44] | |||
Dextromethorphan |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dextromethorphan inhibits the activity of KCNH2 | [44] | |||
Hydroxyzine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Hydroxyzine inhibits the activity of KCNH2 | [45] | |||
Digoxin |
6 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Digoxin inhibits the expression of KCNH2 | [46] | |||
Ouabain |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ouabain inhibits the expression of KCNH2 | [46] | |||
Chlorpheniramine |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chlorpheniramine inhibits the activity of KCNH2 | [47] | |||
Dalfampridine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dalfampridine inhibits the activity of KCNH2 | [48] | |||
Amantadine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Amantadine inhibits the activity of KCNH2 | [49] | |||
Grepafloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Grepafloxacin inhibits the activity of KCNH2 | [49] | |||
Venlafaxine Hydrochloride |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Venlafaxine Hydrochloride inhibits the activity of KCNH2 | [49] | |||
Econazole |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Econazole inhibits the activity of KCNH2 | [50] | |||
Calcitriol |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Calcitriol increases the expression of KCNH2 | [51] | |||
Testosterone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Testosterone increases the expression of KCNH2 | [51] | |||
Arsenic Trioxide |
16 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Arsenic Trioxide inhibits the expression of KCNH2 | [52] | |||
Crizotinib |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Crizotinib inhibits the activity of KCNH2 | [53] | |||
Clarithromycin |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clarithromycin inhibits the activity of KCNH2 | [54] | |||
Flecainide |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Flecainide inhibits the activity of KCNH2 | [54] | |||
Fluvoxamine |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fluvoxamine inhibits the activity of KCNH2 | [54] | |||
Glyburide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Glyburide inhibits the activity of KCNH2 | [54] | |||
Idarubicin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Idarubicin inhibits the activity of KCNH2 | [54] | |||
Imipramine |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Imipramine inhibits the activity of KCNH2 | [54] | |||
Lidocaine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Lidocaine inhibits the activity of KCNH2 | [54] | |||
Mexiletine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Mexiletine inhibits the activity of KCNH2 | [54] | |||
Phentolamine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Phentolamine inhibits the activity of KCNH2 | [54] | |||
Ranolazine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ranolazine inhibits the activity of KCNH2 | [54] | |||
Tacrine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tacrine inhibits the activity of KCNH2 | [54] | |||
Tolcapone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tolcapone inhibits the activity of KCNH2 | [54] | |||
Cisplatin |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cisplatin inhibits the expression of KCNH2 | [55] | |||
Azelastine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Azelastine inhibits the activity of KCNH2 | [56] | |||
Benzatropine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Benzatropine inhibits the activity of KCNH2 | [56] | |||
Cefotetan |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cefotetan inhibits the activity of KCNH2 | [56] | |||
Cepharanthine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cepharanthine inhibits the activity of KCNH2 | [56] | |||
Chlorprothixene |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chlorprothixene inhibits the activity of KCNH2 | [56] | |||
Clemastine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clemastine inhibits the activity of KCNH2 | [56] | |||
Clofazimine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clofazimine inhibits the activity of KCNH2 | [56] | |||
Clotrimazole |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clotrimazole inhibits the activity of KCNH2 | [56] | |||
Diphenylpyraline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Diphenylpyraline inhibits the activity of KCNH2 | [56] | |||
Duloxetine Hydrochloride |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Duloxetine Hydrochloride inhibits the activity of KCNH2 | [56] | |||
Dutasteride |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dutasteride inhibits the activity of KCNH2 | [56] | |||
Eletriptan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Eletriptan inhibits the activity of KCNH2 | [56] | |||
Epinastine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Epinastine inhibits the activity of KCNH2 | [56] | |||
Fentanyl |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fentanyl inhibits the activity of KCNH2 | [56] | |||
Fluorescein |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fluorescein inhibits the activity of KCNH2 | [56] | |||
Flurazepam |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Flurazepam inhibits the activity of KCNH2 | [56] | |||
Miconazole |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Miconazole inhibits the activity of KCNH2 | [56] | |||
Oxiconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Oxiconazole inhibits the activity of KCNH2 | [56] | |||
Palonosetron |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Palonosetron inhibits the activity of KCNH2 | [56] | |||
Perphenazine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Perphenazine inhibits the activity of KCNH2 | [56] | |||
Promazine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Promazine inhibits the activity of KCNH2 | [56] | |||
Pyrithione zinc |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pyrithione zinc inhibits the activity of KCNH2 | [56] | |||
Quetiapine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Quetiapine inhibits the activity of KCNH2 | [56] | |||
Rescinnamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rescinnamine inhibits the activity of KCNH2 | [56] | |||
Rosuvastatin Calcium |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rosuvastatin Calcium inhibits the activity of KCNH2 | [56] | |||
Rotigotine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rotigotine inhibits the activity of KCNH2 | [56] | |||
Salmeterol Xinafoate |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Salmeterol Xinafoate inhibits the activity of KCNH2 | [56] | |||
Semaxanib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Semaxanib inhibits the activity of KCNH2 | [56] | |||
Sertraline |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sertraline inhibits the activity of KCNH2 | [56] | |||
Sorafenib |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sorafenib inhibits the activity of KCNH2 | [56] | |||
Tazarotene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tazarotene inhibits the activity of KCNH2 | [56] | |||
Terconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Terconazole inhibits the activity of KCNH2 | [56] | |||
Toremifene |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Toremifene inhibits the activity of KCNH2 | [56] | |||
Triclabendazole |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Triclabendazole inhibits the activity of KCNH2 | [56] | |||
Triflupromazine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Triflupromazine inhibits the activity of KCNH2 | [56] | |||
Triprolidine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Triprolidine inhibits the activity of KCNH2 | [56] | |||
Ziprasidone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ziprasidone inhibits the activity of KCNH2 | [56] | |||
Erlotinib Hydrochloride |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Erlotinib Hydrochloride inhibits the activity of KCNH2 | [57] | |||
Fluoxetine |
7 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fluoxetine inhibits the expression of KCNH2 | [57] | |||
Imatinib Mesylate |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Imatinib Mesylate inhibits the activity of KCNH2 | [57] | |||
Nilotinib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nilotinib inhibits the expression of KCNH2 | [57] | |||
Vandetanib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Vandetanib inhibits the expression of KCNH2 | [57] | |||
Amiodarone |
8 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Amiodarone inhibits the activity of KCNH2 | [54] | |||
Loratadine |
8 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Loratadine inhibits the activity of KCNH2 | [58] | |||
Carvedilol |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Carvedilol inhibits the activity of KCNH2 | [39] | |||
Quinidine |
13 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Quinidine inhibits the activity of KCNH2 | [56] | |||
Chlorpromazine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chlorpromazine inhibits the activity of KCNH2 | [54] | |||
Verapamil |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Verapamil inhibits the activity of KCNH2 | [59] | |||
Trazodone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Trazodone inhibits the activity of KCNH2 | [56] | |||
Tretinoin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tretinoin inhibits the expression of KCNH2 | [60] | |||
Sotalol |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sotalol inhibits the activity of KCNH2 | [59] | |||
Droperidol |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Droperidol inhibits the activity of KCNH2 | [56] | |||
Disopyramide |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Disopyramide inhibits the activity of KCNH2 | [56] | |||
Desipramine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Desipramine inhibits the activity of KCNH2 | [54] | |||
Reserpine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Reserpine inhibits the activity of KCNH2 | [56] | |||
Tamoxifen |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tamoxifen inhibits the activity of KCNH2 | [56] | |||
Sunitinib |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sunitinib inhibits the activity of KCNH2 | [54] | |||
Valproic Acid |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Valproic Acid increases the expression of KCNH2 | [61] | |||
Nefazodone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nefazodone inhibits the activity of KCNH2 | [56] | |||
Daunorubicin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Daunorubicin inhibits the expression of KCNH2 | [62] | |||
Mitoxantrone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Mitoxantrone inhibits the expression of KCNH2 | [62] | |||
Doxorubicin |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Doxorubicin inhibits the expression of KCNH2 | [63] | |||
Desloratadine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Desloratadine inhibits the activity of KCNH2 | [58] | |||
Ciprofloxacin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ciprofloxacin inhibits the activity of KCNH2 | [64], [65] | |||
Linagliptin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Linagliptin inhibits the activity of KCNH2 | [66] | |||
Betrixaban |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Betrixaban inhibits the activity of KCNH2 | [67] | |||
Bicalutamide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bicalutamide inhibits the activity of KCNH2 | [68] | |||
Ximelegatran |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ximelegatran inhibits the activity of KCNH2 | [69] | |||
Gemifloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Gemifloxacin inhibits the activity of KCNH2 | [65] | |||
Linezolid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Linezolid inhibits the activity of KCNH2 | [65] | |||
Vancomycin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Vancomycin inhibits the activity of KCNH2 | [65] | |||
Vorinostat |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Vorinostat inhibits the activity of KCNH2 | [70] | |||
Propafenone |
6 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Propafenone inhibits the activity of KCNH2 | [71] | |||
Modafinil |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Modafinil inhibits the activity of KCNH2 | [72] | |||
Phenytoin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Phenytoin inhibits the activity of KCNH2 | [73] | |||
Mefloquine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Mefloquine inhibits the activity of KCNH2 | [74] | |||
Pentamidine |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pentamidine inhibits the activity of KCNH2 | [75] | |||
Drug Marketed but not Approved by US FDA |
|||||
Rotenone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rotenone inhibits the activity of KCNH2 | [54] | |||
Ebastine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ebastine inhibits the activity of KCNH2 | [56] | |||
Profenamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Profenamine inhibits the activity of KCNH2 | [56] | |||
Thonzonium bromide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Thonzonium bromide inhibits the activity of KCNH2 | [56] | |||
Drug in Phase 4 Trial |
|||||
Dihydrotestosterone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dihydrotestosterone inhibits the activity of KCNH2 | [96] | |||
Drug in Phase 3 Trial |
|||||
Volinanserin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Volinanserin inhibits the activity of KCNH2 | [19], [20] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Litoxetine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Litoxetine inhibits the activity of KCNH2 | [27] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
BMS-927711 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
BMS-927711 inhibits the activity of KCNH2 | [28] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Tramiprosate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tramiprosate inhibits the activity of KCNH2 | [29] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Vitamin E |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Vitamin E increases the expression of KCNH2 | [83] | |||
Curcumin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Curcumin inhibits the activity of KCNH2 | [56] | |||
Manidipine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Manidipine inhibits the activity of KCNH2 | [56] | |||
Domperidone |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Domperidone inhibits the activity of KCNH2 | [56] | |||
Fasudil |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fasudil inhibits the activity of KCNH2 | [101], [69] | |||
NVP-LAQ824 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
NVP-LAQ824 inhibits the activity of KCNH2 | [70] | |||
MK-3102 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
MK-3102 inhibits the activity of KCNH2 | [112] | |||
BAF312 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
BAF312 inhibits the activity of KCNH2 | [113] | |||
Bardoxolone methyl |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bardoxolone methyl inhibits the activity of KCNH2 | [117] | |||
Drug in Phase 2 Trial |
|||||
Staurosporine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Staurosporine inhibits the transportation of Astemizole by KCNH2 | [1] | |||
Affected Drug/Substrate |
Astemizole | Modulation Type | Inhibition | ||
PF-00734200 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PF-00734200 inhibits the activity of KCNH2 | [26] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
TD-5108 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
TD-5108 inhibits the activity of KCNH2 | [15] | |||
Cell System |
Chinese hamster ovary (CHO) cells-KCNH2 | ||||
AR9281 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
AR9281 inhibits the activity of KCNH2 | [30] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
HP-184 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
HP-184 blocks the activity of KCNH2 | [92] | |||
BMS-582949 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
BMS-582949 inhibits the activity of KCNH2 | [103] | |||
MGCD-0103 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
MGCD-0103 inhibits the activity of KCNH2 | [70] | |||
PDX-101 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PDX-101 inhibits the activity of KCNH2 | [70] | |||
MS-275 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
SNDX-275 inhibits the activity of KCNH2 | [70] | |||
PF-03715455 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PF-03715455 inhibits the activity of KCNH2 | [107] | |||
Piboserod |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Piboserod inhibits the activity of KCNH2 | [109] | |||
PF-3893787 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PF-3893787 inhibits the activity of KCNH2 | [110] | |||
GSK239512 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
GSK239512 inhibits the activity of KCNH2 | [111] | |||
NVP-AUY922 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
NVP-AUY922 inhibits the activity of KCNH2 | [114] | |||
BMS-911543 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
BMS-911543 inhibits the activity of KCNH2 | [115] | |||
Drug in Phase 1/2 Trial |
|||||
CX-4945 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
CX-4945 inhibits the activity of KCNH2 | [106] | |||
CEP-32496 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
CEP-32496 inhibits the activity of KCNH2 | [108] | |||
Drug in Phase 1 Trial |
|||||
Mibefradil |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Mibefradil inhibits the activity of KCNH2 | [7] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Radiprodil |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Radiprodil inhibits the activity of KCNH2 | [31] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
2-deoxyglucose |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
2-deoxyglucose inhibits the activity of KCNH2 | [76] | |||
Adenosine Triphosphate |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Adenosine Triphosphate inhibits the activity of KCNH2 | [76] | |||
Geldanamycin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Geldanamycin inhibits the expression of KCNH2 | [77] | |||
AY-27,255 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
AY-27,255 inhibits the activity of KCNH2 | [41] | |||
Beta-cyclodextrins |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Beta-cyclodextrins inhibits the activity of KCNH2 | [80] | |||
Naringenin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Naringenin inhibits the activity of KCNH2 | [81] | |||
Cibenzoline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cibenzoline inhibits the activity of KCNH2 | [54] | |||
Trichostatin A |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Trichostatin A inhibits the expression of KCNH2 | [85] | |||
Fingolimod Hydrochloride |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fingolimod Hydrochloride inhibits the activity of KCNH2 | [86] | |||
Bromperidol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bromperidol inhibits the activity of KCNH2 | [56] | |||
Clotiapine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clotiapine inhibits the activity of KCNH2 | [56] | |||
Denopamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Denopamine inhibits the activity of KCNH2 | [56] | |||
Fendiline |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fendiline inhibits the activity of KCNH2 | [56] | |||
Ipriflavone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ipriflavone inhibits the activity of KCNH2 | [56] | |||
KB-2796 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
KB-2796 inhibits the activity of KCNH2 | [56] | |||
M-813 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
M-813 inhibits the activity of KCNH2 | [56] | |||
MJ-13105 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
MJ-13105 inhibits the activity of KCNH2 | [56] | |||
Pericyazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pericyazine inhibits the activity of KCNH2 | [56] | |||
Pizotifen |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pizotifen inhibits the activity of KCNH2 | [56] | |||
Prenylamine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Prenylamine inhibits the activity of KCNH2 | [56] | |||
Quinacrine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Quinacrine inhibits the activity of KCNH2 | [56] | |||
Vincamine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Vincamine inhibits the activity of KCNH2 | [56] | |||
Retigabine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Retigabine affects the activity of KCNH2 | [89] | |||
Ajmaline |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ajmaline inhibits the activity of KCNH2 | [54] | |||
Sertindole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sertindole inhibits the activity of KCNH2 | [54] | |||
Lidoflazine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Lidoflazine inhibits the activity of KCNH2 | [56] | |||
Benzethonium |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Benzethonium inhibits the activity of KCNH2 | [54] | |||
Isoquine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Isoquine inhibits the activity of KCNH2 | [93] | |||
Turofexorate isopropyl |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Turofexorate isopropyl inhibits the activity of KCNH2 | [97] | |||
Temanogrel |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Temanogrel inhibits the activity of KCNH2 | [100] | |||
MK-7246 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
MK-7246 inhibits the activity of KCNH2 | [105] | |||
Drug in Preclinical Test |
|||||
Proadifen |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Proadifen inhibits the activity of KCNH2 | [56] | |||
Discontinued Drug |
|||||
Fananserin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fananserin inhibits the activity of KCNH2 | [19] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
PRX-00023 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PRX-00023 inhibits the activity of KCNH2 | [21] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
PNU-282987 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PNU-282987 inhibits the activity of KCNH2 | [22] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
YM60828 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
YM60828 inhibits the activity of KCNH2 | [23] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Ronacaleret |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ronacaleret inhibits the activity of KCNH2 | [95] | |||
GSK163090 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
GSK163090 inhibits the activity of KCNH2 | [104] | |||
Investigative Drug |
|||||
Cyclorgdfv |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cyclorgdfv inhibits the activity of KCNH2 | [21] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Diphenyl(Piperidin-4-Yl)Methanol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Diphenyl(Piperidin-4-Yl)Methanol inhibits the activity of KCNH2 | [2] | |||
3,9-Dihydro-N-Desmethyl-N-Isopropylerythromycin A |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
3,9-Dihydro-N-Desmethyl-N-Isopropylerythromycin A inhibits the activity of KCNH2 | [11] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Glucose |
10 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Glucose inhibits the activity of KCNH2 | [76] | |||
Ginsenoside Rb1 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ginsenoside Rb1 affects the activity of KCNH2 | [78] | |||
Cyamemazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cyamemazine inhibits the activity of KCNH2 | [82] | |||
Malachite green |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Malachite green inhibits the activity of KCNH2 | [50] | |||
Aprindine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Aprindine inhibits the activity of KCNH2 | [56] | |||
Bopindolol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bopindolol inhibits the activity of KCNH2 | [56] | |||
Isoconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Isoconazole inhibits the activity of KCNH2 | [56] | |||
1-(1-(2-Fluorophenyl)-2-(2-(Trifluoromethoxy)Phenyl)Ethyl)Piperazine (Enantiomeric Mix) |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
1-(1-(2-Fluorophenyl)-2-(2-(Trifluoromethoxy)Phenyl)Ethyl)Piperazine (Enantiomeric Mix) inhibits the activity of KCNH2 | [91] | |||
1-(1-(4-Fluorophenyl)-2-(2-(Trifluoromethoxy)Phenyl)Ethyl)Piperazine (Enantiomeric Mix) |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
1-(1-(4-Fluorophenyl)-2-(2-(Trifluoromethoxy)Phenyl)Ethyl)Piperazine (Enantiomeric Mix) inhibits the activity of KCNH2 | [91] | |||
1-(2-(2-(Difluoromethoxy)Phenyl)-1-Phenylethyl)Piperazine (Enantiomeric Mix) |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
1-(2-(2-(Difluoromethoxy)Phenyl)-1-Phenylethyl)Piperazine (Enantiomeric Mix) inhibits the activity of KCNH2 | [91] | |||
Premafloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Premafloxacin inhibits the activity of KCNH2 | [64] | |||
Triphenylmethanamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Triphenylmethanamine inhibits the activity of KCNH2 | [94] | |||
PHA-666859 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PHA-666859 inhibits the activity of KCNH2 | [98] | |||
1-(2,3-Dichlorophenyl)-2,2,2-Trifluoro-1-(1-(4-Fluorophenyl)-1H-Indazol-5-Yl)Ethanol (Enantiomeric Mix) |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
1-(2,3-Dichlorophenyl)-2,2,2-Trifluoro-1-(1-(4-Fluorophenyl)-1H-Indazol-5-Yl)Ethanol (Enantiomeric Mix) inhibits the activity of KCNH2 | [99] | |||
1-(3-Chloro-4-Fluorophenyl)-2,2,2-Trifluoro-1-(1-(4-Fluorophenyl)-1H-Indazol-5-Yl)Ethanol (Enantiomeric Mix) |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
1-(3-Chloro-4-Fluorophenyl)-2,2,2-Trifluoro-1-(1-(4-Fluorophenyl)-1H-Indazol-5-Yl)Ethanol (Enantiomeric Mix) inhibits the activity of KCNH2 | [99] | |||
Nifevirocn |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nifevirocn inhibits the activity of KCNH2 | [102] | |||
Acid-activated omeprazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acid-activated omeprazole inhibits the activity of KCNH2 | [69] | |||
GSK189254A |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
GSK189254A inhibits the activity of KCNH2 | [111] | |||
Saccharin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Saccharin inhibits the activity of KCNH2 | [116] | |||
Drug Withdrawn |
|||||
Terfenadine |
17 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Terfenadine inhibits the transportation of Astemizole by KCNH2 | [1] | |||
Affected Drug/Substrate |
Astemizole | Modulation Type | Inhibition | ||
DT Modulation2 |
Terfenadine inhibits the activity of KCNH2 | [2] | |||
DT Modulation3 |
Terfenadine inhibits the activity of KCNH2 | [3] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Astemizole |
13 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Astemizole inhibits the activity of KCNH2 | [7], [24], [25] | |||
Cell System |
Human embryonic kidney 293 cells (HEK293)-KCNH2 | ||||
Nimesulide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nimesulide inhibits the activity of KCNH2 | [54] | |||
Zimeldine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Zimeldine inhibits the activity of KCNH2 | [54] | |||
Benzydamine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Benzydamine inhibits the activity of KCNH2 | [56] | |||
Flupenthixol |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Flupenthixol inhibits the activity of KCNH2 | [56] | |||
Niguldipine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Niguldipine inhibits the activity of KCNH2 | [56] | |||
Natural Product |
|||||
Mitragynine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Mitragynine inhibits the expression of KCNH2 | [88] | |||
DT Modulation1 |
Curcumin results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Particulate Matter |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Particulate Matter increases the expression of KCNH2 | [90] | |||
Resveratrol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Resveratrol inhibits the reaction Arsenic Trioxide results in decreased activity of KCNH2 protein | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Acute Toxic Substance |
|||||
Mercury |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Mercury increases the expression of KCNH2 | [79] | |||
Strychnine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Strychnine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Health and Environmental Toxicant |
|||||
Butyraldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Butyraldehyde increases the expression of KCNH2 | [87] | |||
Herbicide |
|||||
Atrazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Atrazine increases the expression of KCNH2 | [84] | |||
Chemical Compound |
|||||
DT Modulation1 |
2-(4-(2-(3,4-dichlorophenyl)ethyl)phenylamino)benzoic acid inhibits the reaction Terfenadine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
beta-Cyclodextrins analog inhibits the reaction Terfenadine results in decreased activity of KCNH2 protein | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Chlorobutanol promotes the reaction Terfenadine binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Ciclopirox inhibits the reaction Terfenadine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Hydrogen Peroxide inhibits the reaction Terfenadine results in decreased activity of KCNH2 protein mutant form | [147] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Terfenadine binds to and results in decreased activity of KCNH2 protein | [164] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
Terfenadine binds to KCNH2 protein | [144] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
Terfenadine co-treated with dofetilide binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
Terfenadine co-treated with ergotoxin, Centruroides noxius binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
Terfenadine co-treated with Fluvoxamine binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation11 |
Terfenadine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation12 |
Terfenadine promotes the reaction Chlorobutanol binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation13 |
Terfenadine promotes the reaction Ketoconazole results in decreased activity of KCNH2 protein | [190] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation14 |
Terfenadine results in decreased activity of KCNH2 protein | [145] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Pimozide inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Pimozide results in decreased activity of KCNH2 protein | [153] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Thioridazine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Thioridazine results in decreased activity of KCNH2 protein | [153] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Bepridil binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Bepridil inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Bepridil results in decreased activity of KCNH2 protein | [153] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Haloperidol inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Haloperidol results in decreased activity of KCNH2 protein | [153] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Clozapine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Risperidone inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Aripiprazole inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Aripiprazole results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Olanzapine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Olanzapine results in decreased activity of KCNH2 protein | [169] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Erythromycin affects the reaction KCNH2 protein results in decreased susceptibility to Doxorubicin | [180] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Erythromycin binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Erythromycin binds to KCNH2 protein | [144] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Erythromycin results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
KCNH2 gene SNP affects the susceptibility to Quinine | [210] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Quinine results in decreased activity of KCNH2 protein | [210] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Moxifloxacin results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
beta-Cyclodextrins analog inhibits the reaction Cisapride results in decreased activity of KCNH2 protein | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Cisapride affects the localization of KCNH2 protein mutant form | [142] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Cisapride binds to and results in decreased activity of KCNH2 protein | [164] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Cisapride binds to KCNH2 protein | [144] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Cisapride inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Cisapride results in decreased activity of KCNH2 protein | [165] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Mibefradil inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Mibefradil results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Astemizole affects the localization of KCNH2 protein mutant form | [142] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Astemizole binds to and results in decreased activity of KCNH2 protein | [143] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Astemizole binds to KCNH2 gene polymorphism | [144] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Astemizole binds to KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Astemizole inhibits the reaction Arsenic Trioxide results in increased degradation of KCNH2 protein | [139] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Astemizole inhibits the reaction Digoxin results in decreased activity of KCNH2 protein | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
Astemizole inhibits the reaction Digoxin results in decreased metabolism of KCNH2 protein modified form | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
Astemizole inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
Astemizole results in decreased activity of KCNH2 protein | [145] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
dofetilide analog inhibits the reaction Astemizole binds to KCNH2 protein | [146] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation11 |
Hydrogen Peroxide inhibits the reaction Astemizole results in decreased activity of KCNH2 protein mutant form | [147] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation12 |
Potassium promotes the reaction Astemizole binds to KCNH2 protein | [146] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Pentobarbital results in decreased activity of KCNH2 protein | [32] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Probucol results in decreased activity of KCNH2 protein SNP | [33] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Dronedarone results in decreased activity of KCNH2 protein | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Potassium inhibits the reaction Dronedarone results in decreased activity of KCNH2 protein | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Metoclopramide results in decreased activity of KCNH2 protein | [35] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Gabapentin results in decreased activity of KCNH2 protein | [36] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Lamotrigine results in decreased activity of KCNH2 protein | [36] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Topiramate results in decreased activity of KCNH2 protein | [36] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Lovastatin affects the activity of KCNH2 protein | [38] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Metoprolol results in decreased activity of KCNH2 protein | [39] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Metoprolol results in decreased activity of KCNH2 protein binds to KCNH2 protein | [188] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Mesoridazine results in decreased activity of KCNH2 protein | [40] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Dipyridamole results in decreased activity of KCNH2 protein | [41] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
KCNH2 protein mutant form results in decreased susceptibility to Ketoconazole | [189] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Ketoconazole affects the activity of KCNH2 protein mutant form | [42] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Ketoconazole affects the localization of KCNH2 | [42] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Ketoconazole affects the localization of KCNH2 protein mutant form | [42] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Ketoconazole binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Ketoconazole co-treated with desloratadine co-treated with Loratadine results in decreased activity of KCNH2 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
Ketoconazole co-treated with desloratadine results in decreased activity of KCNH2 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
Ketoconazole co-treated with Loratadine results in decreased activity of KCNH2 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
Ketoconazole results in decreased activity of KCNH2 | [42] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
Ketoconazole results in decreased activity of KCNH2 protein | [189] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation11 |
Terfenadine promotes the reaction Ketoconazole results in decreased activity of KCNH2 protein | [190] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Codeine results in decreased activity of KCNH2 protein | [44] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Dextromethorphan results in decreased activity of KCNH2 protein | [44] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Hydroxyzine results in decreased activity of KCNH2 protein | [45] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Astemizole inhibits the reaction Digoxin results in decreased activity of KCNH2 protein | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Astemizole inhibits the reaction Digoxin results in decreased metabolism of KCNH2 protein modified form | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Digoxin results in decreased activity of KCNH2 protein | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
KCNH2 gene affects the susceptibility to Digoxin | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Sodium deficiency inhibits the reaction Digoxin results in decreased expression of KCNH2 protein | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Ouabain inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Ouabain results in decreased activity of KCNH2 protein | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Chlorpheniramine affects the activity of KCNH2 protein | [38] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Chlorpheniramine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Chlorpheniramine results in decreased activity of KCNH2 protein | [47] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Amantadine results in decreased activity of KCNH2 protein | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Venlafaxine Hydrochloride results in decreased activity of KCNH2 protein | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Econazole results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Econazole results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Testosterone co-treated with Calcitriol results in increased expression of KCNH2 mRNA | [51] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Testosterone co-treated with Calcitriol results in increased expression of KCNH2 mRNA | [51] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Arsenic Trioxide affects the expression of and results in increased activity of KCNH2 protein | [135] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Arsenic Trioxide results in decreased activity of KCNH2 protein | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Arsenic Trioxide results in decreased expression of and affects the localization of and results in decreased activity of KCNH2 protein | [137] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Arsenic Trioxide results in decreased localization of KCNH2 protein | [138] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Arsenic Trioxide results in increased degradation of KCNH2 protein | [139] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Arsenic Trioxide results in increased expression of KCNH2 mRNA | [140] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
Astemizole inhibits the reaction Arsenic Trioxide results in increased degradation of KCNH2 protein | [139] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction Arsenic Trioxide results in increased degradation of KCNH2 protein | [139] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
fexofenadine inhibits the reaction Arsenic Trioxide results in increased degradation of KCNH2 protein | [139] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
Matrines inhibits the reaction Arsenic Trioxide results in decreased localization of KCNH2 protein | [141] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation11 |
MIR21 mRNA promotes the reaction Arsenic Trioxide results in decreased expression of KCNH2 protein | [137] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation12 |
MIR23A mRNA promotes the reaction Arsenic Trioxide results in decreased expression of and affects the localization of and results in decreased activity of KCNH2 protein | [137] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation13 |
oxymatrine inhibits the reaction Arsenic Trioxide results in decreased localization of KCNH2 protein | [141] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation14 |
Ranolazine inhibits the reaction Arsenic Trioxide results in increased degradation of KCNH2 protein | [139] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation15 |
Resveratrol inhibits the reaction Arsenic Trioxide results in decreased activity of KCNH2 protein | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Crizotinib results in decreased activity of KCNH2 protein | [53] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Clarithromycin results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
KCNE2 protein mutant form binds to KCNH2 protein which results in increased susceptibility to Clarithromycin | [167] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Flecainide binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Flecainide results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Fluvoxamine binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Fluvoxamine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Fluvoxamine results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Terfenadine co-treated with Fluvoxamine binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Glyburide results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Idarubicin results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Imipramine binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Imipramine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Imipramine results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Lidocaine results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Mexiletine results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Phentolamine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Phentolamine results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Ranolazine inhibits the reaction Arsenic Trioxide results in increased degradation of KCNH2 protein | [139] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Ranolazine results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Tacrine results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Tolcapone results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Rotenone results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Cisplatin results in increased expression of KCNH2 | [166] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
KCNH2 results in increased susceptibility to Cisplatin | [166] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Cefotetan results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Chlorprothixene results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Clemastine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Clofazimine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Clotrimazole results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Duloxetine Hydrochloride results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Dutasteride results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Fentanyl results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Fluorescein results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Flurazepam results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Miconazole results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Palonosetron results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Perphenazine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Perphenazine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Promazine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Rosuvastatin Calcium results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Salmeterol Xinafoate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Sertraline results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Sorafenib results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Toremifene results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Triclabendazole results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Triflupromazine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Triprolidine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Erlotinib Hydrochloride affects the activity of KCNH2 protein | [53] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Erlotinib Hydrochloride results in decreased activity of KCNH2 protein | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Fluoxetine affects the localization of KCNH2 protein | [186] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Fluoxetine binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Fluoxetine inhibits the reaction KCNH2 protein results in increased transport of Potassium | [187] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Fluoxetine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Fluoxetine results in decreased activity of KCNH2 protein | [186] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
KCNH2 protein affects the susceptibility to Fluoxetine | [186] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Imatinib Mesylate results in decreased activity of KCNH2 protein | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Amiodarone affects the activity of KCNH2 protein | [129] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Amiodarone binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Amiodarone inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Amiodarone promotes the reaction naringenin results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Amiodarone results in decreased activity of KCNH2 protein | [132] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
naringenin promotes the reaction Amiodarone results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
Potassium inhibits the reaction Amiodarone results in decreased activity of KCNH2 protein | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
desloratadine co-treated with Loratadine results in decreased activity of KCNH2 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Ketoconazole co-treated with desloratadine co-treated with Loratadine results in decreased activity of KCNH2 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Ketoconazole co-treated with Loratadine results in decreased activity of KCNH2 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Loratadine affects the activity of KCNH2 protein | [38] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Loratadine binds to and results in decreased activity of KCNH2 protein | [191] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Loratadine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
Loratadine results in decreased activity of KCNH2 protein | [192] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Carvedilol affects the activity of KCNH2 protein | [129] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Carvedilol results in decreased activity of KCNH2 protein | [157] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Acids inhibits the reaction Quinidine results in decreased activity of KCNH2 protein | [149] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
KCNH2 gene mutant form results in decreased susceptibility to Quinidine | [209] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
KCNH2 gene SNP affects the susceptibility to Quinidine | [210] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
naringenin promotes the reaction Quinidine results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Potassium inhibits the reaction Quinidine results in decreased activity of KCNH2 protein | [150] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Quinidine affects the activity of KCNH2 protein | [129] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
Quinidine affects the localization of KCNH2 protein mutant form | [165] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
Quinidine binds to KCNH2 protein | [144] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
Quinidine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
Quinidine promotes the reaction naringenin results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation11 |
Quinidine results in decreased activity of KCNH2 protein | [165] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation12 |
Quinidine results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Chlorpromazine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Chlorpromazine results in decreased activity of KCNH2 protein | [163] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Verapamil inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Verapamil results in decreased activity of KCNH2 protein | [153] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Verapamil results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Trazodone results in decreased activity of KCNH2 protein | [214] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
KCNH2 gene mutant form results in decreased susceptibility to Sotalol | [209] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Potassium inhibits the reaction Sotalol results in decreased activity of KCNH2 protein | [150] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Sotalol analog binds to KCNH2 protein | [144] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Sotalol results in decreased activity of KCNH2 protein | [181] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Droperidol inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Droperidol results in decreased activity of KCNH2 protein | [181] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Disopyramide binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Disopyramide results in decreased activity of KCNH2 protein | [177] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Desipramine results in decreased activity of KCNH2 protein | [173] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Reserpine results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Reserpine results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Tamoxifen binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Tamoxifen inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Tamoxifen results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Tamoxifen results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Sunitinib results in decreased activity of KCNH2 protein | [212] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Valproic Acid affects the expression of KCNH2 mRNA | [215] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Valproic Acid results in increased methylation of KCNH2 gene | [61] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Erythromycin affects the reaction KCNH2 protein results in decreased susceptibility to Doxorubicin | [180] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
KCNH2 protein results in decreased susceptibility to Doxorubicin | [180] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Ciprofloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Propafenone affects the activity of KCNH2 protein | [38] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Propafenone analog binds to and results in decreased activity of KCNH2 protein | [207] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Propafenone binds to and results in decreased activity of KCNH2 protein | [207] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Propafenone inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Propafenone results in decreased activity of KCNH2 protein | [177] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Phenytoin results in decreased activity of KCNH2 protein | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Mefloquine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Mefloquine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Pentamidine affects the localization of and affects the activity of KCNH2 protein | [203] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Pentamidine affects the localization of and results in decreased activity of KCNH2 protein | [204] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Pentamidine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Pentamidine results in decreased activity of KCNH2 protein | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Adenosine Triphosphate deficiency results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
alpha-Tocopherol inhibits the reaction Glucose results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Deoxyglucose co-treated with Glucose deficiency results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Deoxyglucose inhibits the reaction Glucose results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Deoxyglucose promotes the reaction Glucose deficiency results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Glucose deficiency results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Glucose results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction Glucose results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
Pyruvic Acid inhibits the reaction Deoxyglucose co-treated with Glucose deficiency results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
Sodium Cyanide inhibits the reaction Glucose results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Vitamin E inhibits the reaction TNF protein results in decreased activity of KCNH2 protein | [194] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Zimeldine results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Fingolimod Hydrochloride results in decreased activity of KCNH2 protein | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Pentanal |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pentanal increases the expression of KCNH2 | [87] | |||
DT Modulation1 |
Fendiline results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Prenylamine results in decreased activity of KCNH2 protein | [38] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Quinacrine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Vincamine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Proadifen results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Aprindine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Benzydamine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Flupenthixol results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Ajmaline results in decreased activity of KCNH2 protein | [127] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Domperidone inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Domperidone results in decreased activity of KCNH2 protein | [35] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
KCNH2 gene SNP affects the susceptibility to Domperidone | [179] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Lidoflazine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Lidoflazine results in decreased activity of KCNH2 protein | [38] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Benzethonium results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Benzethonium results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
1,3-ditolylguanidine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
1,3-ditolylguanidine results in decreased activity of KCNH2 protein | [118] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
1-(5-fluoropentyl)-3-(1-naphthoyl)indole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
1-(5-fluoropentyl)-3-(1-naphthoyl)indole results in decreased activity of KCNH2 protein | [119] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
18-methoxycoronaridine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
18-methoxycoronaridine results in decreased activity of KCNH2 protein | [120] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
1-Methyl-3-isobutylxanthine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Colforsin co-treated with 1-Methyl-3-isobutylxanthine results in increased activity of ADRB1 protein binds to ADRB2 protein affects the reaction KCNH2 protein results in increased transport of Potassium | [121] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
1-pentyl-3-(1-naphthoyl)indole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
1-pentyl-3-(1-naphthoyl)indole results in decreased activity of KCNH2 protein | [119] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
2-(2-(3,4-dichlorophenyl)-2,3-dihydro-1H-isoindol-5-ylamino)nicotinic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
2-(2-(3,4-dichlorophenyl)-2,3-dihydro-1H-isoindol-5-ylamino)nicotinic acid results in increased activity of KCNH2 protein | [122] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
3,3'-diethylthiacarbocyanine iodide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
3,3'-diethylthiacarbocyanine iodide results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
3,4,5,3',4'-pentachlorobiphenyl |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
3,4,5,3',4'-pentachlorobiphenyl affects the activity of KCNH2 protein | [123] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
4-AcO-DET |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
4-AcO-DET results in decreased activity of KCNH2 protein | [124] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
4-Aminopyridine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
4-Aminopyridine results in decreased activity of KCNH2 protein | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
4-HO-MET |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
4-HO-MET results in decreased activity of KCNH2 protein | [124] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a)quinoxalin-5(6H)-one |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a)quinoxalin-5(6H)-one inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
9-(2-hydroxy-3-nonyl)adenine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
9-(2-hydroxy-3-nonyl)adenine results in decreased activity of KCNH2 protein | [41] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
abrine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
abrine results in decreased expression of KCNH2 mRNA | [125] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Aldehydes |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Aldehydes results in increased expression of KCNH2 mRNA | [128] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
alinidine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
alinidine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
alpha-Tocopherol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
alpha-Tocopherol inhibits the reaction Glucose results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
alpidem |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
alpidem results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
alverine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
alverine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Amitriptyline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Amitriptyline inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
amorolfine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
amorolfine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
amperozide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
amperozide inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Amsacrine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Amsacrine binds to and results in decreased activity of KCNH2 protein | [133] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
aprofen |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
aprofen results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
aristolochic acid I |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
aristolochic acid I results in increased expression of KCNH2 mRNA | [134] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Azaperone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Azaperone results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
azaspiracid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
azaspiracid binds to and results in decreased activity of KCNH2 protein | [148] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
azelastine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
azelastine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
azimilide |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acids inhibits the reaction azimilide results in decreased activity of KCNH2 protein | [149] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
azimilide promotes the reaction naringenin results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
azimilide results in decreased activity of KCNH2 protein | [149] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
naringenin promotes the reaction azimilide results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Potassium inhibits the reaction azimilide results in decreased activity of KCNH2 protein | [150] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
balofloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
balofloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Benactyzine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Benactyzine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
benfluorex |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
benfluorex results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
benoxinate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
benoxinate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Benperidol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Benperidol results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Benzo(a)pyrene |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Benzo(a)pyrene affects the methylation of KCNH2 intron | [126] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Benzo(a)pyrene affects the methylation of KCNH2 polyA tail | [126] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Benzo(a)pyrene results in decreased methylation of KCNH2 3' UTR | [152] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Benzo(a)pyrene results in decreased methylation of KCNH2 exon | [152] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Benzo(a)pyrene results in increased methylation of KCNH2 promoter | [152] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
benzo(e)pyrene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
benzo(e)pyrene results in increased methylation of KCNH2 intron | [126] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Benztropine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Benztropine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
benzyloxycarbonylleucyl-leucyl-leucine aldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction Arsenic Trioxide results in increased degradation of KCNH2 protein | [139] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
beta-Cyclodextrins |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
beta-Cyclodextrins analog inhibits the reaction Cisapride results in decreased activity of KCNH2 protein | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
beta-Cyclodextrins analog inhibits the reaction E 4031 results in decreased activity of KCNH2 protein | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
beta-Cyclodextrins analog inhibits the reaction Terfenadine results in decreased activity of KCNH2 protein | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
beta-Cyclodextrins analog results in decreased activity of KCNH2 protein | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Betahistine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Betahistine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bifemelane |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bifemelane results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bisphenol A |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bisphenol A results in decreased methylation of KCNH2 gene | [154] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bisphenol S |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bisphenol S co-treated with Fulvestrant results in decreased methylation of KCNH2 gene | [154] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bopindolol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bopindolol results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Brefeldin A |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Brefeldin A promotes the reaction vandetanib results in decreased expression of KCNH2 protein modified form | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Brefeldin A results in decreased expression of KCNH2 protein modified form | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Bromhexine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bromhexine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bromocyclen |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bromocyclen results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bromperidol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bromperidol results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Brompheniramine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Brompheniramine results in decreased activity of KCNH2 protein | [155] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bucindolol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bucindolol results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
buclizine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
buclizine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bunamidine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bunamidine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Butaclamol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Butaclamol results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
butoconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
butoconazole results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
butyraldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
butyraldehyde results in increased expression of KCNH2 mRNA | [87] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
camylofine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
camylofine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Carbachol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
KCNH2 protein mutant form affects the susceptibility to Carbachol | [156] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
carbetapentane |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
carbetapentane results in decreased activity of KCNH2 protein | [44] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
carbinoxamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
carbinoxamine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cepharanthine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cepharanthine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cetalkonium chloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cetalkonium chloride results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cetyldimethylethylammonium |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cetyldimethylethylammonium results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
CGP 52608 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
CGP 52608 promotes the reaction RORA protein binds to KCNH2 gene | [158] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
chloramine-T |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
chloramine-T results in increased oxidation of and results in decreased activity of KCNH2 protein | [159] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Chlorobutanol |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chlorobutanol binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Chlorobutanol promotes the reaction Methadone results in decreased activity of KCNH2 protein | [161] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Chlorobutanol promotes the reaction Terfenadine binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Chlorobutanol results in decreased activity of KCNH2 protein | [161] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Terfenadine promotes the reaction Chlorobutanol binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Chloroform |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chloroform results in decreased activity of KCNH2 protein | [162] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Ciclopirox |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ciclopirox inhibits the reaction Terfenadine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Ciclopirox promotes the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cifenline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cifenline results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Cinacalcet |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cinacalcet results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cinchonine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cinchonine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
clebopride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
clebopride results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
clobutinol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
clobutinol results in decreased activity of KCNH2 protein | [44] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
clofedanol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
clofedanol results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
clofexamide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
clofexamide results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Clomipramine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clomipramine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Clopenthixol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clopenthixol results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cloperastine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cloperastine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
clothiapine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
clothiapine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cobaltous chloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cobaltous chloride results in decreased expression of KCNH2 mRNA | [168] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Colforsin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Colforsin co-treated with 1-Methyl-3-isobutylxanthine results in increased activity of ADRB1 protein binds to ADRB2 protein affects the reaction KCNH2 protein results in increased transport of Potassium | [121] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cyamemazine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cyamemazine metabolite results in decreased activity of KCNH2 protein | [82] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
cyamemazine results in decreased activity of KCNH2 protein | [169] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cyamemazine sulfoxide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cyamemazine sulfoxide results in decreased activity of KCNH2 protein | [82] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Cyclosporine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cyclosporine results in decreased methylation of KCNH2 promoter | [170] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cyclovirobuxine D |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cyclovirobuxine D results in decreased activity of KCNH2 protein | [171] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
danofloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
danofloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Dantrolene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dantrolene results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
danuglipron |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
danuglipron results in increased activity of KCNH2 protein | [172] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
darifenacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
darifenacin results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
decominol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
decominol results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
denopamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
denopamine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Deoxyglucose |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Deoxyglucose co-treated with Glucose deficiency results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Deoxyglucose inhibits the reaction Glucose results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Deoxyglucose promotes the reaction Glucose deficiency results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Deoxyglucose results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Pyruvic Acid inhibits the reaction Deoxyglucose co-treated with Glucose deficiency results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
desloratadine |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
desloratadine co-treated with Loratadine results in decreased activity of KCNH2 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
desloratadine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Ketoconazole co-treated with desloratadine co-treated with Loratadine results in decreased activity of KCNH2 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Ketoconazole co-treated with desloratadine results in decreased activity of KCNH2 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
desmethylastemizole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
desmethylastemizole binds to and results in decreased activity of KCNH2 protein | [143] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
dexbrompheniramine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
dexbrompheniramine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Dexetimide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dexetimide results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
diallyl trisulfide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
diallyl trisulfide results in decreased activity of KCNH2 protein | [174] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
diallyl trisulfide results in decreased expression of and results in decreased activity of KCNH2 protein | [175] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
diazoline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
diazoline results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
dibenzheptropine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
dibenzheptropine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Dibucaine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dibucaine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
didecyldimethylammonium |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
didecyldimethylammonium results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
didecyldimethylammonium results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
difloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
difloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
dimethisoquin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
dimethisoquin results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
di-n-butylphosphoric acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
di-n-butylphosphoric acid affects the expression of KCNH2 mRNA | [176] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
diphenylguanidine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
diphenylguanidine results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
diphenylguanidine results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
diphenylpyraline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
diphenylpyraline results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Dithiazanine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dithiazanine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Dobutamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dobutamine results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
dofetilide |
14 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acids inhibits the reaction dofetilide results in decreased activity of KCNH2 protein | [149] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
dofetilide analog inhibits the reaction Astemizole binds to KCNH2 protein | [146] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
dofetilide analog inhibits the reaction dofetilide binds to KCNH2 protein | [146] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
dofetilide binds to and results in decreased activity of KCNH2 protein | [178] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
dofetilide binds to KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
dofetilide inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
dofetilide promotes the reaction naringenin results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
dofetilide results in decreased activity of KCNH2 protein | [147] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
Hydrogen Peroxide inhibits the reaction dofetilide results in decreased activity of KCNH2 protein mutant form | [147] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
naringenin promotes the reaction dofetilide results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation11 |
Potassium affects the reaction dofetilide analog inhibits the reaction dofetilide binds to KCNH2 protein | [146] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation12 |
Potassium inhibits the reaction dofetilide results in decreased activity of KCNH2 protein | [150] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation13 |
Potassium promotes the reaction dofetilide binds to KCNH2 protein | [146] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation14 |
Terfenadine co-treated with dofetilide binds to and results in decreased activity of KCNH2 protein | [160] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
dolasetron |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
dolasetron results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
domiphen |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
domiphen results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
domiphen results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Doxepin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Doxepin inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
dyclonine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
dyclonine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
E 4031 |
13 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
beta-Cyclodextrins analog inhibits the reaction E 4031 results in decreased activity of KCNH2 protein | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
E 4031 affects the localization of KCNH2 protein mutant form | [165] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
E 4031 binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
E 4031 binds to KCNH2 protein | [182] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
E 4031 inhibits the reaction fexofenadine results in increased activity of KCNH2 protein mutant form | [183] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
E 4031 inhibits the reaction Flufenamic Acid promotes the reaction KCNH2 protein results in increased transport of Potassium | [184] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
E 4031 inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
E 4031 inhibits the reaction Niflumic Acid promotes the reaction KCNH2 protein results in increased transport of Potassium | [184] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
E 4031 results in decreased activity of KCNE2 protein binds to KCNH2 protein | [167] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
E 4031 results in decreased activity of KCNH2 protein | [165] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation11 |
E 4031 results in increased activity of KCNH2 protein mutant form | [142] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation12 |
E 4031 results in increased glycosylation of and affects the localization of KCNH2 protein mutant form | [142] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation13 |
KCNE2 protein binds to KCNH2 protein which results in increased susceptibility to E 4031 | [167] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ebastine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ebastine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
eburnamonine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
eburnamonine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
eletriptan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
eletriptan results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
eliprodil |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
eliprodil inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
emedastine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
emedastine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
(endo-N-8-methyl-8-azabicyclo-(3.2.1)oct-3-yl)-2,3-dihydro-3-isopropyl-2-oxo-1H-benzimidazol-1-carboxamide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
(endo-N-8-methyl-8-azabicyclo-(3.2.1)oct-3-yl)-2,3-dihydro-3-isopropyl-2-oxo-1H-benzimidazol-1-carboxamide results in decreased activity of KCNH2 protein | [185] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Enoxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Enoxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Enrofloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Enrofloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
epinastine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
epinastine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ethaverine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ethaverine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ezogabine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ezogabine affects the activity of KCNH2 protein | [89] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
fananserin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
fananserin results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
febantel |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
febantel results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
fenoverine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
fenoverine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
fexofenadine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
E 4031 inhibits the reaction fexofenadine results in increased activity of KCNH2 protein mutant form | [183] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
fexofenadine inhibits the reaction Arsenic Trioxide results in increased degradation of KCNH2 protein | [139] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
fexofenadine results in increased activity of KCNH2 protein mutant form | [183] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
flazolone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
flazolone results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Fleroxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fleroxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Flufenamic Acid |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
E 4031 inhibits the reaction Flufenamic Acid promotes the reaction KCNH2 protein results in increased transport of Potassium | [184] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Flufenamic Acid promotes the reaction KCNH2 protein results in increased transport of Potassium | [184] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
fomocain |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
fomocain results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Formoterol Fumarate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Formoterol Fumarate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Fulvestrant |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bisphenol S co-treated with Fulvestrant results in decreased methylation of KCNH2 gene | [154] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Gatifloxacin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Gatifloxacin binds to and results in decreased activity of KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Gatifloxacin binds to and results in decreased activity of KCNH2 protein which results in decreased export of Potassium | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
geldanamycin |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
geldanamycin affects the localization of KCNH2 protein | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
geldanamycin inhibits the reaction KCNH2 protein binds to HSP90AA1 protein | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
geldanamycin results in decreased activity of KCNH2 protein | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
geldanamycin results in decreased expression of KCNH2 protein modified form | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
geldanamycin results in increased degradation of KCNH2 protein | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Gentian Violet |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Gentian Violet results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ginsenoside Rb1 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ginsenoside Rb1 affects the activity of KCNH2 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ginsenoside Rf |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ginsenoside Rf affects the activity of KCNH2 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ginsenoside Rg1 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ginsenoside Rg1 affects the activity of KCNH2 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
GR 103691 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
GR 103691 results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Gramicidin |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Gramicidin results in decreased expression of KCNH2 protein modified form | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Potassium inhibits the reaction Gramicidin results in decreased expression of KCNH2 protein modified form | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Rubidium inhibits the reaction Gramicidin results in decreased expression of KCNH2 protein modified form | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
grepafloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
grepafloxacin results in decreased activity of KCNH2 protein | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
halofantrine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
halofantrine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Hexetidine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Hexetidine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
homosalate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
homosalate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Hydrogen Peroxide |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Hydrogen Peroxide inhibits the reaction Astemizole results in decreased activity of KCNH2 protein mutant form | [147] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Hydrogen Peroxide inhibits the reaction dofetilide results in decreased activity of KCNH2 protein mutant form | [147] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Hydrogen Peroxide inhibits the reaction Terfenadine results in decreased activity of KCNH2 protein mutant form | [147] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Hydroxychloroquine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein which results in decreased export of Potassium | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Ibogaine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ibogaine results in decreased activity of KCNH2 protein | [120] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ICI 118551 |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ICI 118551 results in decreased activity of KCNH2 protein | [39] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
ICI 118551 results in decreased activity of KCNH2 protein binds to KCNH2 protein | [188] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ifenprodil |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ifenprodil results in decreased activity of KCNH2 protein | [118] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
SM 21 promotes the reaction ifenprodil results in decreased activity of KCNH2 protein | [118] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Iofetamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Iofetamine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ipriflavone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ipriflavone results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
isamoltane |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
isamoltane results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
isoconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
isoconazole results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Ivabradine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ivabradine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
JWH-073 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
JWH-073 results in decreased activity of KCNH2 protein | [119] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
L 706000 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
L 706000 binds to and results in decreased activity of KCNH2 protein | [164] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
lenperone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
lenperone results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
levomepromazine maleate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
levomepromazine maleate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
lifibrate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
lifibrate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
liranaftate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
liranaftate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Lobeline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Lobeline results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Lofepramine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Lofepramine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
lomefloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
lomefloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
lomerizine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
lomerizine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Loxapine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Loxapine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
lubeluzole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
lubeluzole binds to and results in decreased activity of KCNH2 protein | [193] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
malachite green |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
malachite green results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
malachite green results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
manganese(III)-tetrakis(4-benzoic acid)porphyrin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction Glucose results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction TNF protein results in decreased activity of KCNH2 protein | [194] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
manidipine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
manidipine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Maprotiline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Maprotiline inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
mebeverine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
mebeverine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
mepazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
mepazine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Methadone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chlorobutanol promotes the reaction Methadone results in decreased activity of KCNH2 protein | [161] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Methadone results in decreased activity of KCNH2 protein | [161] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Methadyl Acetate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Methadyl Acetate inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Methapyrilene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Methapyrilene results in increased methylation of KCNH2 intron | [126] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
methdilazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
methdilazine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Methiothepin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Methiothepin results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
methixene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
methixene results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
methylmercuric chloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
methylmercuric chloride results in decreased expression of KCNH2 mRNA | [195] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
methylselenic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
methylselenic acid results in increased expression of KCNH2 mRNA | [196] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
mitemcinal |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
mitemcinal metabolite results in decreased activity of KCNH2 protein | [197] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
mitemcinal results in decreased activity of KCNH2 protein | [197] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
mitragynine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
mitragynine binds to and results in decreased activity of KCNH2 protein | [88] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
mitragynine results in decreased expression of KCNH2 protein | [88] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
mizolastine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
mizolastine results in decreased activity of KCNH2 protein | [198] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
monorden |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
monorden results in decreased activity of KCNH2 protein | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
monorden results in decreased expression of KCNH2 protein modified form | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction TGFB1 protein results in decreased expression of KCNH2 protein | [199] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nadifloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
nadifloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
naftifine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
naftifine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
naringenin |
9 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Amiodarone promotes the reaction naringenin results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
azimilide promotes the reaction naringenin results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
dofetilide promotes the reaction naringenin results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
naringenin promotes the reaction Amiodarone results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
naringenin promotes the reaction azimilide results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
naringenin promotes the reaction dofetilide results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
naringenin promotes the reaction Quinidine results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
naringenin results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
Quinidine promotes the reaction naringenin results in decreased activity of KCNH2 protein | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nefazodone |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
nefazodone affects the activity of KCNH2 protein | [200] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
nefazodone binds to and results in decreased activity of KCNH2 protein | [201] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
nefazodone results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nifekalant |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
nifekalant affects the activity of KCNH2 protein | [129] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
nifekalant results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Niflumic Acid |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
E 4031 inhibits the reaction Niflumic Acid promotes the reaction KCNH2 protein results in increased transport of Potassium | [184] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Niflumic Acid promotes the reaction KCNH2 protein results in increased transport of Potassium | [184] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
niguldipine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
niguldipine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nilotinib |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
N-butanoylsphingosine inhibits the reaction nilotinib results in decreased expression of KCNH2 protein modified form | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
nilotinib results in decreased activity of KCNH2 protein | [53] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
nilotinib results in decreased expression of and results in decreased activity of KCNH2 protein | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
nilotinib results in decreased expression of KCNH2 protein modified form | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nimesulide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
nimesulide results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Nitrovin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nitrovin results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Nonachlazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nonachlazine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Norfloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Norfloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
norfluoxetine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
KCNH2 protein affects the susceptibility to norfluoxetine | [186] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
norfluoxetine affects the localization of KCNH2 protein | [186] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
norfluoxetine results in decreased activity of KCNH2 protein | [186] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Nortriptyline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nortriptyline inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
octoclothepine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
octoclothepine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Ofloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ofloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
oligomycin B |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
oligomycin B results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
o,p'-DDT |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
o,p'-DDT results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
o,p'-DDT results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
orbifloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
orbifloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
oxeladin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
oxeladin results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
oxiconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
oxiconazole results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
oxymatrine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
oxymatrine inhibits the reaction Arsenic Trioxide results in decreased localization of KCNH2 protein | [141] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
oxymatrine results in increased expression of KCNH2 protein | [141] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
oxyphencyclimine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
oxyphencyclimine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Paliperidone Palmitate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Paliperidone Palmitate results in decreased activity of KCNH2 protein | [202] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
panaxadiol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
panaxadiol affects the activity of KCNH2 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
panaxatriol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
panaxatriol affects the activity of KCNH2 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Pefloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pefloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
pentanal |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
pentanal results in increased expression of KCNH2 mRNA | [87] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
perfluorooctanoic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
perfluorooctanoic acid results in decreased expression of KCNH2 mRNA | [205] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Perhexiline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Perhexiline binds to KCNH2 protein | [144] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
perhexiline maleate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
perhexiline maleate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
periciazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
periciazine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
perospirone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
perospirone results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
phenothiazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
phenothiazine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Phenylephrine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Phenylephrine affects the reaction KCNH2 protein results in increased transport of Potassium | [121] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
pimobendan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
pimobendan results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
piperacetazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
piperacetazine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
piperidolate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
piperidolate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Pizotyline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pizotyline results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Potassium |
25 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Colforsin co-treated with 1-Methyl-3-isobutylxanthine results in increased activity of ADRB1 protein binds to ADRB2 protein affects the reaction KCNH2 protein results in increased transport of Potassium | [121] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
E 4031 inhibits the reaction Flufenamic Acid promotes the reaction KCNH2 protein results in increased transport of Potassium | [184] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
E 4031 inhibits the reaction Niflumic Acid promotes the reaction KCNH2 protein results in increased transport of Potassium | [184] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Flufenamic Acid promotes the reaction KCNH2 protein results in increased transport of Potassium | [184] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Fluoxetine inhibits the reaction KCNH2 protein results in increased transport of Potassium | [187] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Gatifloxacin binds to and results in decreased activity of KCNH2 protein which results in decreased export of Potassium | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein which results in decreased export of Potassium | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
iron(III)-ascorbic acid complex results in increased abundance of Reactive Oxygen Species affects the reaction KCNH2 protein affects the transport of Potassium | [206] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
KCNH2 protein binds to KCNE2 protein which results in increased transport of Potassium | [188] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
KCNH2 protein binds to KCNH2 protein which results in increased transport of Potassium | [188] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation11 |
KCNH2 protein results in increased transport of Potassium | [187] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation12 |
Niflumic Acid promotes the reaction KCNH2 protein results in increased transport of Potassium | [184] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation13 |
Phenylephrine affects the reaction KCNH2 protein results in increased transport of Potassium | [121] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation14 |
Potassium affects the reaction dofetilide analog inhibits the reaction dofetilide binds to KCNH2 protein | [146] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation15 |
Potassium affects the stability of and affects the localization of KCNH2 protein modified form | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation16 |
Potassium deficiency affects the folding of KCNH2 protein | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation17 |
Potassium inhibits the reaction Amiodarone results in decreased activity of KCNH2 protein | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation18 |
Potassium inhibits the reaction azimilide results in decreased activity of KCNH2 protein | [150] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation19 |
Potassium inhibits the reaction dofetilide results in decreased activity of KCNH2 protein | [150] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation20 |
Potassium inhibits the reaction Dronedarone results in decreased activity of KCNH2 protein | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation21 |
Potassium inhibits the reaction Gramicidin results in decreased expression of KCNH2 protein modified form | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation22 |
Potassium inhibits the reaction Quinidine results in decreased activity of KCNH2 protein | [150] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation23 |
Potassium inhibits the reaction Sotalol results in decreased activity of KCNH2 protein | [150] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation24 |
Potassium promotes the reaction Astemizole binds to KCNH2 protein | [146] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation25 |
Potassium promotes the reaction dofetilide binds to KCNH2 protein | [146] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
prenylamine lactate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
prenylamine lactate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
pridinol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
pridinol results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Procainamide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Procainamide binds to and results in decreased activity of KCNH2 protein | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
profenamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
profenamine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Proflavine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Proflavine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
propionaldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
propionaldehyde results in increased expression of KCNH2 mRNA | [87] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Propranolol |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Propranolol results in decreased activity of KCNH2 protein | [39] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Propranolol results in decreased activity of KCNH2 protein binds to KCNE2 protein | [188] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Propranolol results in decreased activity of KCNH2 protein binds to KCNH2 protein | [188] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
proroxan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
proroxan results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
prosultiamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
prosultiamine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
pyrathiazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
pyrathiazine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
pyridine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
pyridine analog binds to KCNH2 protein | [208] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Pyrilamine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pyrilamine affects the activity of KCNH2 protein | [38] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Pyrilamine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
pyrithione zinc |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
pyrithione zinc results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Pyruvic Acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pyruvic Acid inhibits the reaction Deoxyglucose co-treated with Glucose deficiency results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
pyrvinium |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
pyrvinium results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Quetiapine Fumarate |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Quetiapine Fumarate inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Quetiapine Fumarate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
quifenadine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
quifenadine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ractopamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ractopamine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
rescinnamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
rescinnamine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
rimcazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
rimcazole results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Ritanserin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ritanserin inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Robenidine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Robenidine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Rolipram |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rolipram results in decreased activity of KCNH2 protein | [41] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Rose Bengal |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rose Bengal results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
rotigotine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
rotigotine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Rubidium |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rubidium inhibits the reaction Gramicidin results in decreased expression of KCNH2 protein modified form | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sarafloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sarafloxacin binds to KCNH2 protein | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Semaxinib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Semaxinib results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sertaconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sertaconazole results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sertindole |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sertindole inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
sertindole results in decreased activity of KCNH2 protein | [38] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Simendan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Simendan results in decreased activity of KCNH2 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
SM 21 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
SM 21 promotes the reaction ifenprodil results in decreased activity of KCNH2 protein | [118] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Sodium |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sodium deficiency inhibits the reaction Digoxin results in decreased expression of KCNH2 protein | [46] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sodium arsenite |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sodium arsenite affects the methylation of KCNH2 gene | [211] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Sodium Cyanide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sodium Cyanide inhibits the reaction Glucose results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
syrosingopine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
syrosingopine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tazarotene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tazarotene results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tecastemizole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tecastemizole binds to and results in decreased activity of KCNH2 protein | [143] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tenovin-1 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tenovin-1 results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Terbinafine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Terbinafine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
terconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
terconazole results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
terodiline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
terodiline inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tetramethrin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tetramethrin results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tetraoctylammonium bromide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tetraoctylammonium bromide results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
tetraoctylammonium bromide results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Thallium |
72 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
2-(4-(2-(3,4-dichlorophenyl)ethyl)phenylamino)benzoic acid inhibits the reaction Terfenadine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
2-(4-(2-(3,4-dichlorophenyl)ethyl)phenylamino)benzoic acid promotes the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a)quinoxalin-5(6H)-one inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Amiodarone inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Amitriptyline inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
amperozide inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
Aripiprazole inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
Astemizole inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
Benzethonium results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
Bepridil inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation11 |
Chlorpheniramine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation12 |
Chlorpromazine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation13 |
Ciclopirox inhibits the reaction Terfenadine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation14 |
Ciclopirox promotes the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation15 |
Cisapride inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation16 |
Clomipramine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation17 |
Clozapine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation18 |
didecyldimethylammonium results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation19 |
diphenylguanidine results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation20 |
dofetilide inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation21 |
domiphen results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation22 |
Domperidone inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation23 |
Doxepin inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation24 |
Droperidol inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation25 |
E 4031 inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation26 |
Econazole results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation27 |
eliprodil inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation28 |
Fluoxetine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation29 |
Fluvoxamine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation30 |
Haloperidol inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation31 |
Imipramine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation32 |
KCNH2 protein results in increased import of Thallium | [213] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation33 |
KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation34 |
KCNH2 results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation35 |
Lidoflazine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation36 |
Loratadine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation37 |
malachite green results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation38 |
Maprotiline inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation39 |
Mefloquine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation40 |
Methadyl Acetate inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation41 |
Mibefradil inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation42 |
N-(n-butyl)-(bis-fluorophenyl)methoxytropane inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation43 |
Nortriptyline inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation44 |
Olanzapine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation45 |
o,p'-DDT results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation46 |
Ouabain inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation47 |
Pentamidine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation48 |
Perphenazine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation49 |
Phentolamine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation50 |
Pimozide inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation51 |
Propafenone inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation52 |
Pyrilamine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation53 |
Quetiapine Fumarate inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation54 |
Quinidine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation55 |
Quinidine results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation56 |
Reserpine results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation57 |
Risperidone inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation58 |
Ritanserin inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation59 |
sertindole inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation60 |
Tamoxifen inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation61 |
Tamoxifen results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation62 |
Terfenadine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation63 |
terodiline inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation64 |
tetraoctylammonium bromide results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation65 |
Thioridazine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation66 |
Trifluoperazine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation67 |
Trifluperidol inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation68 |
Tritolyl Phosphates results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation69 |
vanoxerine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation70 |
Verapamil inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation71 |
Verapamil results in decreased activity of KCNH2 protein which results in decreased import of Thallium | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation72 |
vinpocetine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
thiaton |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
thiaton results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
thiphenamil |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
thiphenamil results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
thonzonium bromide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
thonzonium bromide results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tiamulin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tiamulin results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tipepidine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tipepidine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
trichostatin A |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
trichostatin A results in decreased expression of KCNH2 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
triethyl-(beta-4-stilbenoxyethyl)ammonium |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
triethyl-(beta-4-stilbenoxyethyl)ammonium results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Trifluoperazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Trifluoperazine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Trifluperidol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Trifluperidol inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
trimeprazine tartrate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
trimeprazine tartrate results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Tripelennamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tripelennamine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
triphenyl phosphate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
triphenyl phosphate affects the expression of KCNH2 mRNA | [176] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tri-xylenyl phosphate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tri-xylenyl phosphate results in decreased activity of KCNH2 protein | [50] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
valnemulin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
valnemulin results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
vandetanib |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Brefeldin A promotes the reaction vandetanib results in decreased expression of KCNH2 protein modified form | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
N-butanoylsphingosine inhibits the reaction vandetanib results in decreased expression of KCNH2 protein modified form | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
vandetanib binds to KCNH2 protein | [216] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
vandetanib results in decreased expression of and results in decreased activity of KCNH2 protein | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
vandetanib results in decreased expression of KCNH2 protein modified form | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
vanoxerine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
vanoxerine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
vapiprost |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
vapiprost results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
vesnarinone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
KCNH2 gene SNP affects the susceptibility to vesnarinone | [210] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
vesnarinone results in decreased activity of KCNH2 protein | [210] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
vinpocetine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
vinpocetine inhibits the reaction KCNH2 protein results in increased transport of Thallium | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
vinpocetine results in decreased activity of KCNH2 protein | [41] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
xaliproden |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
xaliproden results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Xanthine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Xanthine co-treated with XDH protein results in decreased activity of KCNH2 protein | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
zatebradine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
zatebradine results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ziprasidone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ziprasidone results in decreased activity of KCNH2 protein | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
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