Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0458 Transporter Info
Gene Name	SLC6A6
Transporter Name	Sodium- and chloride-dependent taurine transporter
Gene ID	6533
UniProt ID	P31641

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC6A6 gene in glioblastoma multiforme condition			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of SLC6A6 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
BACH2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Transcription regulator protein BACH2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription regulator protein BACH2 (BACH2) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
JUN		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in acute kidney injury condition			[6]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Affected Drug/Substrate	Cisplatin
Studied Phenotype	Acute kidney injury [ICD11: GB60]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Madin-Darby canine kidney cells (MDCK)
Detailed Description	Transcription factor Jun (JUN) has been reported to activate the transcription of SLC6A6 gene in acute kidney injury condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Repression of SLC6A6 gene in health condition			[7]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	Down regulating
Experimental Material	Human kidney human embryonic kidney 293 cells (HEK 293)
Detailed Description	Transcription factor Jun (JUN) has been reported to repress the transcription of SLC6A6 gene in health condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
JUNB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Transcription factor JunB		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunB (JUNB) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
JUND		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in coronary artery disease condition			[8]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC6A6 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Bone marrow; Brain; Breast; Cervix; Colon; Coronary artery; Embryo; Liver; Lung; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
CLOCK		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in colorectal cancer condition			[9]
TF Protein Name	Circadian locomoter output cycles protein kaput		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Circadian locomoter output cycles protein kaput (CLOCK) has been reported to activate the transcription of SLC6A6 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC6A6 gene in Burkitt lymphoma condition			[10]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC6A6 gene in Burkitt lymphoma condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Embryo; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in coronary artery disease condition			[8]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 21 (TCF21) has been reported to bind to the SLC6A6 gene in coronary artery disease condition, which affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Brain; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in breast cancer condition			[11]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) has been reported to activate the transcription of SLC6A6 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in prostate cancer condition			[12]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC6A6 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Estrogen receptor (ESR1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
NR1H3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in atherosclerotic condition			[13]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of SLC6A6 gene in atherosclerotic condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
PPARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in health condition			[14]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Placenta
Related DT Changes	Up regulating
Experimental Material	human primary placental trophoblast cell isolates
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of SLC6A6 gene in health condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
RARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Retinoic acid receptor gamma		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor gamma (RARG) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
VDR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in THP1 cells			[15]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC6A6 gene in THP1 cells, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 15 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
EGR1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in tumorigenic prostate condition			[16]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to activate the transcription of SLC6A6 gene in tumorigenic prostate condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Binding to SLC6A6 gene in erythroleukemia condition			[17]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC6A6 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon3	Activation of SLC6A6 gene in defective renal development condition			[18]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	Defective renal development [ICD11: LB30]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Rat Kidney epithelial cells (NRK-52E)
Detailed Description	Early growth response protein 1 (EGR1) has been reported to activate the transcription of SLC6A6 gene in defective renal development condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Foreskin; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Tissue	Blood; Bone marrow; Colon; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp1 (SP1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
WT1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in podocyte condition			[19]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLC6A6 gene in podocyte condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Activation of SLC6A6 gene in defective renal development condition			[18]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	Defective renal development [ICD11: LB30]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Cats
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLC6A6 gene in defective renal development condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon3	Repression of SLC6A6 gene in health condition			[7]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	Down regulating
Experimental Material	Human kidney human embryonic kidney 293 cells (HEK 293)
Detailed Description	Wilms tumor protein (WT1) has been reported to repress the transcription of SLC6A6 gene in health condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
YY1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Tissue	Blood; Bone marrow; Colon; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in breast cancer condition			[20]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC6A6 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
ZNF83		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Zinc finger protein 83		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 83 (ZNF83) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
POU2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	POU domain, class 2, transcription factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
ZEB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Zinc finger E-box-binding homeobox 1		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Embryo; Endoderm; Liver; Lung; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
FOXK1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Forkhead box protein K1		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein K1 (FOXK1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
FOXO3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in tumorigenesis condition			[21]
TF Protein Name	Forkhead box protein O3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein O3 (FOXO3) has been reported to activate the transcription of SLC6A6 gene in tumorigenesis condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
FOXP1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC6A6 gene in embryonic stem cell condition			[22]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC6A6 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
FOXP2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in health condition			[23]
TF Protein Name	Forkhead box protein P2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Forkhead box protein P2 (FOXP2) has been reported to bind to the transcription of SLC6A6 gene in health condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
RFX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	DNA-binding protein RFX5		Transcription Factor Info
Tissue	Cervix; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	DNA-binding protein RFX5 (RFX5) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ELF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Liver; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
FLI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in megakaryocytes condition			[24]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC6A6 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Umbilical cord blood; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Cervix; Liver; Lung; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
MYB		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC6A6 gene in health condition			[7]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	Down regulating
Experimental Material	Human kidney human embryonic kidney 293 cells (HEK 293)
Detailed Description	Transcriptional activator Myb (MYB) has been reported to repress the transcription of SLC6A6 gene in health condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
SPI1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in K562 cells			[25]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC6A6 gene in K562 cells, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Binding to SLC6A6 gene in acute myeloid leukemia condition			[26]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC6A6 gene in acute myeloid leukemia condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon3	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
SPIB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Transcription factor Spi-B		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Spi-B (SPIB) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
MEF2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Myocyte-specific enhancer factor 2A		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myocyte-specific enhancer factor 2A (MEF2A) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
NFAT5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in hyposmolality condition			[27]
TF Protein Name	Nuclear factor of activated T-cells 5		Transcription Factor Info
Studied Phenotype	Hyposmolality [ICD11: 5C72]
Tissue	Thymus
Related DT Changes	Up regulating
Experimental Material	Sprague-Dawley rats
Detailed Description	Nuclear factor of activated T-cells 5 (NFAT5) has been reported to activate the transcription of SLC6A6 gene in hyposmolality condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
RBPJ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in immortal lymphoblast cell lines (LCLs) condition			[28]
TF Protein Name	Recombining binding protein suppressor of hairless		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC6A6 gene in immortal lymphoblast cell lines (LCLs) condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
RELA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in fibrosarcoma condition			[29]
TF Protein Name	Transcription factor p65		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor p65 (RELA) has been reported to activate the transcription of SLC6A6 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC6A6 gene in acute kidney injury condition			[6]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Affected Drug/Substrate	Cisplatin
Studied Phenotype	Acute kidney injury [ICD11: GB60]
Tissue	Kidney
Related DT Changes	Down regulating
Experimental Material	Madin-Darby canine kidney cells (MDCK)
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to repress the transcription of SLC6A6 gene in acute kidney injury condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon2	Repression of SLC6A6 gene in defective renal development condition			[18]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	Defective renal development [ICD11: LB30]
Tissue	Kidney
Related DT Changes	Down regulating
Experimental Material	Cats
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to repress the transcription of SLC6A6 gene in defective renal development condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Transcriptional Phenomenon3	Repression of SLC6A6 gene in health condition			[7]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	Down regulating
Experimental Material	Human kidney human embryonic kidney 293 cells (HEK 293)
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to repress the transcription of SLC6A6 gene in health condition, which leads to a decreased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in epithelial to mesenchymal transition condition			[30]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC6A6 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC6A6 gene in megakaryocytes condition			[24]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC6A6 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC6A6 gene in prostate cancer condition			[31]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC6A6 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[4]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Blood; Brain; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TF Superclass8: beta-Sheet binding to DNA
Class8.1: TATA-binding proteins		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TBP		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[5]
TF Protein Name	TATA-box-binding protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	TATA-box-binding protein (TBP) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
MBD3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[2]
TF Protein Name	Methyl-CpG-binding domain protein 3		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Methyl-CpG-binding domain protein 3 (MBD3) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.
Class10.5: GTF2I domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2I		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC6A6 gene			[3]
TF Protein Name	General transcription factor II-I		Transcription Factor Info
Tissue	Foreskin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	General transcription factor II-I (GTF2I) can directly bind to the SLC6A6 gene, which in turn affects the expression or function of the drug transporter Sodium- and chloride-dependent taurine transporter.

References
1	In vivo RNAi screen for BMI1 targets identifies TGF-BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell. 2013;23(5):660-76.
2	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-264. (ID:ENSG00000131389)
4	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6	Stress-responsive gene TauT and acute kidney injury. J Biomed Sci. 2010 Aug 24;17 Suppl 1(Suppl 1):S28.
7	The taurine transporter: mechanisms of regulation. Acta Physiol (Oxf). 2006 May-Jun;187(1-2):61-73.
8	Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
9	Mutations in the circadian gene CLOCK in colorectal cancer. Mol Cancer Res. 2010;8(7):952-60.
10	Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. PLoS One. 2011;6(11):e26837.
11	Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes Chromosomes Cancer. 2010;49(10):948-62.
12	Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
13	Genome-wide analysis of LXRa activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res. 2013;41(6):3518-31.
14	PPARgama stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPARgama regulating fetal growth. Sci Rep. 2015 Jul 31;5:12650.
15	Patterns of genome-wide VDR locations. PLoS One. 2014;9(4):e96105.
16	Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. Genome Biol. 2008;9(11):R166.
17	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
18	The taurine transporter gene and its role in renal development. Amino Acids. 2000;19(3-4):499-507.
19	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
20	Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
21	Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol. 2013;9:638.
22	An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
23	Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. Nucleic Acids Res. 2013;41(12):5991-6004.
24	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
25	Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol. 2013;41(3):303-15.e1.
26	Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.
27	Expression of osmotic stress-related genes in tissues of normal and hyposmotic rats. Am J Physiol Renal Physiol. 2003 Oct;285(4):F688-93.
28	Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
29	Modulation of gene expression regulated by the transcription factor NF-B/RelA. J Biol Chem. 2014;289(17):11927-11944.
30	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
31	Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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