Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0342 Transporter Info
Gene Name	SLC39A14
Transporter Name	Zinc transporter ZIP14
Gene ID	23516
UniProt ID	Q15043

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
ATF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in hepatic endoplasmic reticulum stres condition			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-4		Transcription Factor Info
Studied Phenotype	Hepatic endoplasmic reticulum stres [ICD11: N.A.]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6J-129S5 hybrid mice
Detailed Description	Cyclic AMP-dependent transcription factor ATF-4 (ATF4) has been reported to activate the transcription of SLC39A14 gene in hepatic endoplasmic reticulum stres condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
ATF6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in hepatic endoplasmic reticulum stres condition			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-6 alpha		Transcription Factor Info
Studied Phenotype	Hepatic endoplasmic reticulum stres [ICD11: N.A.]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6J-129S5 hybrid mice
Detailed Description	Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) has been reported to activate the transcription of SLC39A14 gene in hepatic endoplasmic reticulum stres condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[4]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Bone marrow; Breast; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in liver inflammation condition			[5]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Studied Phenotype	Liver inflammation [ICD11: DB97]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Transcription factor Jun (JUN) has been reported to activate the transcription of SLC39A14 gene in liver inflammation condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[4]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
HIF1A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in inflammation condition			[7]
TF Protein Name	Hypoxia-inducible factor 1-alpha		Transcription Factor Info
Studied Phenotype	Inflammation [ICD11: 1H0Z]
Tissue	Knee
Related DT Changes	Up regulating
Experimental Material	human knee fibroblast-like synoviocyte isolates
Detailed Description	Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to activate the transcription of SLC39A14 gene in inflammation condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in melanoma condition			[8]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC39A14 gene in melanoma condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[1]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Tissue	Coronary artery
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 21 (TCF21) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[1]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[3]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
USF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[4]
TF Protein Name	Upstream stimulatory factor 2		Transcription Factor Info
Tissue	Cervix; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 2 (USF2) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[1]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Breast; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
TFAP2C		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in breast cancer condition			[9]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) has been reported to activate the transcription of SLC39A14 gene in breast cancer condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
Transcriptional Phenomenon2	Direct binding to SLC39A14 gene			[3]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC39A14 gene in health condition			[10]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC39A14 gene in health condition, which leads to an affected expression of the drug transporter Zrt- and Irt-like protein 14.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[3]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
PGR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[4]
TF Protein Name	Progesterone receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Progesterone receptor (PGR) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
PPARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[3]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[1]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
GATA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[3]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
GATA4		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in gastric cancer condition			[11]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC39A14 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
Transcriptional Phenomenon2	Direct binding to SLC39A14 gene			[4]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Tissue	Embryo; Skin; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor GATA-4 (GATA4) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
GATA6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in gastric cancer condition			[11]
TF Protein Name	Transcription factor GATA-6		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC39A14 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC39A14 gene in erythroleukemia condition			[12]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC39A14 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Zrt- and Irt-like protein 14.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in gastric cancer condition			[11]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC39A14 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[1]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[1]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in podocyte condition			[13]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLC39A14 gene in podocyte condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[4]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
CUX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in multiple human cancer types condition			[14]
TF Protein Name	Homeobox protein cut-like 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC39A14 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
HNF1B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[4]
TF Protein Name	Hepatocyte nuclear factor 1-beta		Transcription Factor Info
Tissue	Embryo; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 1-beta (HNF1B) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
NANOG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A14 gene in HESC condition			[15]
TF Protein Name	Homeobox protein NANOG		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Homeobox protein NANOG (NANOG) has been reported to activate the transcription of SLC39A14 gene in HESC condition, which leads to an increased expression of the drug transporter Zrt- and Irt-like protein 14.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[4]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
E2F8		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[3]
TF Protein Name	Transcription factor E2F8		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F8 (E2F8) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC39A14 gene			[10]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC39A14 gene in . condition, which leads to a affected expression of the drug transporter Zrt- and Irt-like protein 14.
Transcriptional Phenomenon2	Direct binding to SLC39A14 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[1]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
ETS2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[4]
TF Protein Name	Protein C-ets-2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-2 (ETS2) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[1]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[1]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[3]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene in colorectal cancers condition			[16]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to bind to the transcription of SLC39A14 gene in colorectal cancers condition, which leads to a affected expression of the drug transporter Zrt- and Irt-like protein 14.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
MEF2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[6]
TF Protein Name	Myocyte-specific enhancer factor 2A		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myocyte-specific enhancer factor 2A (MEF2A) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
TF Superclass6: Immunoglobulin fold
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC39A14 gene in stress response condition			[17]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC39A14 gene in stress response condition, which leads to an affected expression of the drug transporter Zrt- and Irt-like protein 14.
Transcriptional Phenomenon2	Repression of SLC39A14 gene in hepatoblastoma condition			[18]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Down regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to repress the transcription of SLC39A14 gene in hepatoblastoma condition, which leads to a decreased expression of the drug transporter Zrt- and Irt-like protein 14.
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC39A14 gene in epithelial to mesenchymal transition condition			[19]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC39A14 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Zrt- and Irt-like protein 14.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[4]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Bronchus; Ovary
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A14 gene			[3]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Blood; Brain; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC39A14 gene, which in turn affects the expression or function of the drug transporter Zrt- and Irt-like protein 14.

References
1	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2	Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5805-E5814.
3	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5	Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G860-7.
6	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-198. (ID:ENSG00000104635)
7	HIF-1alpha Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn2+ Accumulation in Inflammatory Synoviocytes. Int J Mol Sci. 2021 Jun 14;22(12):6349.
8	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
9	Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes Chromosomes Cancer. 2010;49(10):948-62.
10	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
11	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
12	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
13	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
14	p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
15	Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem. 2011;286(2):1037-45.
16	ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
17	Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res. 2008;36(11):3639-54.
18	The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14. Nutrients. 2017 Dec 8;9(12):1335.
19	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Transcriptional Regulations

Visitor Map

Correspondence