Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0178 Transporter Info
Gene Name	SLC25A19
Transporter Name	Mitochondrial thiamine pyrophosphate carrier
Gene ID	60386
UniProt ID	Q9HC21

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ATF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-2 (ATF2) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
BATF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Basic leucine zipper transcriptional factor ATF-like		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Basic leucine zipper transcriptional factor ATF-like (BATF) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
CREB1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A19 gene in health condition			[5]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) has been reported to activate the transcription of SLC25A19 gene in health condition, which leads to an increased expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Transcriptional Phenomenon2	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
FOS		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Protein c-Fos		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein c-Fos (FOS) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Tissue	Brain; Breast; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 2 (FOSL2) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
JUNB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Transcription factor JunB		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunB (JUNB) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
CLOCK		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Circadian locomoter output cycles protein kaput		Transcription Factor Info
Tissue	Brain; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Circadian locomoter output cycles protein kaput (CLOCK) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
MAX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Protein max		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Colon; Embryo; Liver; Lung; Uterus; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein max (MAX) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
MYC		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC25A19 gene in Burkitt lymphoma condition			[6]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC25A19 gene in Burkitt lymphoma condition, which leads to a decreased expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Transcriptional Phenomenon2	Binding to SLC25A19 gene in embryonic stem cells condition			[7]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC25A19 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A19 gene in coronary artery disease condition			[8]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 21 (TCF21) has been reported to bind to the SLC25A19 gene in coronary artery disease condition, which affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ESR1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A19 gene in breast cancer condition			[9]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Estrogen receptor (ESR1) has been reported to activate the transcription of SLC25A19 gene in breast cancer condition, which leads to an increased expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Transcriptional Phenomenon2	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Estrogen receptor (ESR1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
ESR2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Estrogen receptor beta		Transcription Factor Info
Tissue	Bone; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Estrogen receptor beta (ESR2) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
ESRRA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Steroid hormone receptor ERR1		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Steroid hormone receptor ERR1 (ESRRA) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A19 gene in health condition			[10]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC25A19 gene in health condition, which leads to an affected expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
RXRA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Retinoic acid receptor RXR-alpha		Transcription Factor Info
Tissue	Blood; Colon; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-alpha (RXRA) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
VDR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene in leukemia condition			[11]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Vitamin D3 receptor (VDR) can directly bind to the SLC25A19 gene in leukemia condition, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 11 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Tissue	Tonsil
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	B-cell lymphoma 6 protein (BCL6) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
MECOM		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Histone-lysine N-methyltransferase MECOM		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Histone-lysine N-methyltransferase MECOM (MECOM) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A19 gene in podocyte condition			[12]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLC25A19 gene in podocyte condition, which leads to an increased expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
ZBTB33		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Transcriptional regulator Kaiso		Transcription Factor Info
Tissue	Blood; Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator Kaiso (ZBTB33) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
ZBTB7B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Zinc finger and BTB domain-containing protein 7B		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7B (ZBTB7B) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
ZEB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Zinc finger E-box-binding homeobox 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A19 gene in health condition			[13]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC25A19 gene in health condition, which leads to an affected expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Transcriptional Phenomenon2	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
E2F3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Transcription factor E2F3		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F3 (E2F3) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
E2F4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Transcription factor E2F4		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F4 (E2F4) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Cervix; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
FOXA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A19 gene in prostate carcinoma condition			[14]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC25A19 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Transcriptional Phenomenon2	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC25A19 gene in embryonic stem cell condition			[15]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC25A19 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TFDP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Transcription factor Dp-1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Dp-1 (TFDP1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
ETS1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A19 gene in T cell activation condition			[16]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Protein C-ets-1 (ETS1) has been reported to activate the transcription of SLC25A19 gene in T cell activation condition, which leads to an increased expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Transcriptional Phenomenon2	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Pancreas; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
ETS2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Protein C-ets-2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-2 (ETS2) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Liver; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
IRF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Interferon regulatory factor 4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 4 (IRF4) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[4]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A19 gene in hepatoblastoma condition			[17]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) has been reported to activate the transcription of SLC25A19 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.3: SAND domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GMEB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Glucocorticoid modulatory element-binding protein 1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Glucocorticoid modulatory element-binding protein 1 (GMEB1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[2]
TF Protein Name	Signal transducer and activator of transcription 5B		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Signal transducer and activator of transcription 5B (STAT5B) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A19 gene in megakaryocytes condition			[18]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC25A19 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
RUNX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[3]
TF Protein Name	Runt-related transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A19 gene			[1]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC25A19 gene, which in turn affects the expression or function of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
SMAD3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A19 gene in health condition			[19]
TF Protein Name	Mothers against decapentaplegic homolog 3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to activate the transcription of SLC25A19 gene in health condition, which leads to an increased expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A19 gene in hESCs condition			[19]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC25A19 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Mitochondrial thiamine pyrophosphate carrier.

References
1	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
2	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-255. (ID:ENSG00000125454)
3	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5	Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A. 2005;102(12):4459-64.
6	Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. PLoS One. 2011;6(11):e26837.
7	Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
8	Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
9	Estrogen receptor-dependent regulation of CYP2B6 in human breast cancer cells. Biochim Biophys Acta. 2010;1799(5-6):469-79.
10	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
11	Characterization of genomic vitamin D receptor binding sites through chromatin looping and opening. PLoS One. 2014;9(4):e96184.
12	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
13	Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome. J Biol Chem. 2011;286(14):11985-96.
14	SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
15	An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
16	DNA specificity determinants associate with distinct transcription factor functions. PLoS Genet. 2009;5(12):e1000778.
17	Characterization of the human mitochondrial thiamine pyrophosphate transporter SLC25A19 minimal promoter: a role for NF-Y in regulating basal transcription. Gene. 2013 Oct 10;528(2):248-55.
18	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
19	Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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