Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0146 Transporter Info
Gene Name	SLC22A23
Transporter Name	Solute carrier family 22 member 23
Gene ID	63027
UniProt ID	A1A5C7

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Cervix; Colon; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
JUNB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Transcription factor JunB		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunB (JUNB) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
MAFF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Transcription factor MafF		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor MafF (MAFF) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
XBP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	X-box-binding protein 1		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	X-box-binding protein 1 (XBP1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
MAX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Protein max		Transcription Factor Info
Tissue	Bone marrow; Brain; Cervix; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein max (MAX) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A23 gene in melanoma condition			[5]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC22A23 gene in melanoma condition, which leads to an increased expression of the drug transporter Solute carrier family 22 member 23.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc proto-oncogene protein (MYC) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Embryo; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in prostate cancer condition			[6]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC22A23 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon2	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Androgen receptor		Transcription Factor Info
Tissue	Breast; Cervix; Kidney; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Androgen receptor (AR) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
ESR1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene in breast cancer condition			[7]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Estrogen receptor (ESR1) has been reported to bind to the SLC22A23 gene in breast cancer condition, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon2	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Estrogen receptor (ESR1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
ESR2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in breast cancer condition			[7]
TF Protein Name	Estrogen receptor beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Estrogen receptor beta (ESR2) has been reported to bind to the transcription of SLC22A23 gene in breast cancer condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in health condition			[8]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC22A23 gene in health condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
VDR		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A23 gene in leukemia condition			[9]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC22A23 gene in leukemia condition, which leads to an increased expression of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon2	Binding to SLC22A23 gene in THP-1 human monocytic leukemia cells condition			[10]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC22A23 gene in THP-1 human monocytic leukemia cells condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon3	Activation of SLC22A23 gene in multiple sclerosis condition			[11]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC22A23 gene in multiple sclerosis condition, which leads to an increased expression of the drug transporter Solute carrier family 22 member 23.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in hematopoiesis condition			[12]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC22A23 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon2	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow; Colon; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
GATA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in megakaryocytes condition			[13]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLC22A23 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon2	Activation of SLC22A23 gene in hematopoiesis condition			[12]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC22A23 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Solute carrier family 22 member 23.
GATA3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Tissue	Blood; Brain; Breast; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 15 TF(s) Regulating This DT
BCL11A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	B-cell lymphoma/leukemia 11A		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	B-cell lymphoma/leukemia 11A (BCL11A) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Bone marrow; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Tissue	Blood; Colon; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp1 (SP1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A23 gene in podocyte condition			[14]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of SLC22A23 gene in podocyte condition, which leads to an increased expression of the drug transporter Solute carrier family 22 member 23.
YY1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in melanocyte deficiency condition			[15]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcriptional repressor protein YY1 (YY1) has been reported to bind to the transcription of SLC22A23 gene in melanocyte deficiency condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon2	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Tissue	Blood; Bone marrow; Colon; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in breast cancer condition			[16]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC22A23 gene in breast cancer condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
ZEB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Zinc finger E-box-binding homeobox 1		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F7 (E2F7) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in health condition			[8]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC22A23 gene in health condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon2	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A23 gene in breast cancer condition			[17]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC22A23 gene in breast cancer condition, which leads to an increased expression of the drug transporter Solute carrier family 22 member 23.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Colon; Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ELF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Liver; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
ETV1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	ETS translocation variant 1		Transcription Factor Info
Tissue	GastroIntestine tract; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS translocation variant 1 (ETV1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Bone marrow; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
IRF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Interferon regulatory factor 4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 4 (IRF4) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
SPI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in K562 cells			[18]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC22A23 gene in K562 cells, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon2	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
SPIB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Transcription factor Spi-B		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Spi-B (SPIB) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Blood; Colon; Embryo; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[3]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
STAT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[2]
TF Protein Name	Signal transducer and activator of transcription 1-alpha/beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Signal transducer and activator of transcription 1-alpha/beta (STAT1) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
STAT3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in glioblastoma multiforme condition			[19]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC22A23 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in epithelial to mesenchymal transition condition			[20]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC22A23 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon2	Binding to SLC22A23 gene in health condition			[21]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC22A23 gene in health condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in megakaryocytes condition			[13]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC22A23 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
RUNX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[1]
TF Protein Name	Runt-related transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A23 gene			[4]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC22A23 gene, which in turn affects the expression or function of the drug transporter Solute carrier family 22 member 23.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SMAD4		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A23 gene in epithelial ovarian cancer condition			[22]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC22A23 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Solute carrier family 22 member 23.
Transcriptional Phenomenon2	Activation of SLC22A23 gene in hESCs condition			[23]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC22A23 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Solute carrier family 22 member 23.

References
1	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
2	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-280. (ID:ENSG00000137266)
3	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
6	Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
7	Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation. BMC Genomics. 2011;12:36.
8	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
9	Characterization of genomic vitamin D receptor binding sites through chromatin looping and opening. PLoS One. 2014;9(4):e96184.
10	Patterns of genome-wide VDR locations. PLoS One. 2014;9(4):e96105.
11	Molecular network of chromatin immunoprecipitation followed by deep sequencing-based vitamin D receptor target genes. Mult Scler. 2013;19(8):1035-45.
12	Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
13	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
14	Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
15	YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012;8(5):e1002688.
16	Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
17	FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
18	Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol. 2013;41(3):303-15.e1.
19	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
20	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
21	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
22	ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.
23	Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Transcriptional Regulations

Visitor Map

Correspondence