Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0133 Transporter Info
Gene Name	SLC1A5
Transporter Name	Alanine/serine/cysteine/threonine transporter 2
Gene ID	6510
UniProt ID	Q15758

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 13 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC1A5 gene in glioblastoma multiforme condition			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of SLC1A5 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ATF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in health condition			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-4		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Bone marrow
Related DT Changes	Up regulating
Experimental Material	Mouse bone marrow-derived cells (ST2)
Detailed Description	Cyclic AMP-dependent transcription factor ATF-4 (ATF4) has been reported to activate the transcription of SLC1A5 gene in health condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
BACH2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Transcription regulator protein BACH2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription regulator protein BACH2 (BACH2) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
BATF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Basic leucine zipper transcriptional factor ATF-like		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Basic leucine zipper transcriptional factor ATF-like (BATF) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
FOS		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Protein c-Fos		Transcription Factor Info
Tissue	Bone marrow; Breast; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein c-Fos (FOS) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Tissue	Brain; Breast; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 2 (FOSL2) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene in coronary artery disease condition			[7]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC1A5 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
JUNB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Transcription factor JunB		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunB (JUNB) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A5 gene in coronary artery disease condition			[7]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor JunD (JUND) has been reported to bind to the transcription of SLC1A5 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 12 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ASCL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Achaete-scute homolog 2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 2 (ASCL2) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
EPAS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in pancreatic ductal adenocarcinoma condition			[8]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Affected Drug/Substrate	Gemcitabine
Studied Phenotype	Pancreatic ductal adenocarcinoma [ICD11: 2C10.0]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	Human pancreatic ductal adenocarcinoma cells (MiaPaca-2)
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1) has been reported to activate the transcription of SLC1A5 gene in pancreatic ductal adenocarcinoma condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
HEY1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Hairy/enhancer-of-split related with YRPW motif protein 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Cervix; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
MYC		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in colon cancer condition			[9]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Affected Drug/Substrate	Tryptophan
Studied Phenotype	Colon cancer [ICD11: 2B90]
Tissue	Colon
Related DT Changes	Up regulating
Experimental Material	human colon cancer cell isolates
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to activate the transcription of SLC1A5 gene in colon cancer condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Binding to SLC1A5 gene in HL60 condition			[10]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC1A5 gene in HL60 condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon3	Repression of SLC1A5 gene in Burkitt lymphoma condition			[11]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC1A5 gene in Burkitt lymphoma condition, which leads to a decreased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Breast; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TCF21		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene in coronary artery disease condition			[7]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 21 (TCF21) has been reported to bind to the transcription of SLC1A5 gene in coronary artery disease condition, which leads to a affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Tissue	Coronary artery
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 21 (TCF21) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Colon; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Breast; Cervix; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TFAP2C		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in breast cancer condition			[12]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) has been reported to activate the transcription of SLC1A5 gene in breast cancer condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
NR1H3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in atherosclerotic foam cells condition			[13]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of SLC1A5 gene in atherosclerotic foam cells condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
VDR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene in monocytic leukemia condition			[14]
TF Protein Name	Vitamin D3 receptor		Transcription Factor Info
Affected Drug/Substrate	1,25(OH)2D3
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC1A5 gene in monocytic leukemia condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A5 gene in megakaryocytes condition			[15]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC1A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
GATA2		Click to Show/Hide to Show 4 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A5 gene in megakaryocytes condition			[15]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLC1A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Activation of SLC1A5 gene in hematopoiesis condition			[16]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to activate the transcription of SLC1A5 gene in hematopoiesis condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon3	Binding to SLC1A5 gene in health condition			[17]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLC1A5 gene in health condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon4	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Tissue	Blood; Bone marrow; Umbilical cord blood; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
GATA3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A5 gene in breast cancer condition			[18]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLC1A5 gene in breast cancer condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
GATA6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in gastric cancer condition			[19]
TF Protein Name	Transcription factor GATA-6		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC1A5 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 17 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in CMLJURLMK1 condition			[20]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of SLC1A5 gene in CMLJURLMK1 condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
HINFP		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Histone H4 transcription factor		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Histone H4 transcription factor (HINFP) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Breast; Foreskin; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
MECOM		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Histone-lysine N-methyltransferase MECOM		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Histone-lysine N-methyltransferase MECOM (MECOM) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in health condition			[21]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	White adipose tissue
Related DT Changes	Up regulating
Experimental Material	Mouse white adipose tissue preadipocytes cells (3T3-L1)
Detailed Description	Transcription factor Sp1 (SP1) has been reported to activate the transcription of SLC1A5 gene in health condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
SP3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in health condition			[21]
TF Protein Name	Transcription factor Sp3		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	White adipose tissue
Related DT Changes	Up regulating
Experimental Material	Mouse white adipose tissue preadipocytes cells (3T3-L1)
Detailed Description	Transcription factor Sp3 (SP3) has been reported to activate the transcription of SLC1A5 gene in health condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
SP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Transcription factor Sp4		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp4 (SP4) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
YY1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Colon; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in breast cancer condition			[22]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to activate the transcription of SLC1A5 gene in breast cancer condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
NKX2-1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Homeobox protein Nkx-2.1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein Nkx-2.1 (NKX2-1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Brain; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
SIX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Homeobox protein SIX5		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein SIX5 (SIX5) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A5 gene in MCF7 condition			[23]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC1A5 gene in MCF7 condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
E2F4		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A5 gene in health condition			[24]
TF Protein Name	Transcription factor E2F4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC1A5 gene in health condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Transcription factor E2F4		Transcription Factor Info
Tissue	Bone marrow; Breast; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F4 (E2F4) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Cervix; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC1A5 gene in health condition			[25]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Transcription factor E2F7 (E2F7) has been reported to repress the transcription of SLC1A5 gene in health condition, which leads to a decreased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
E2F8		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Transcription factor E2F8		Transcription Factor Info
Tissue	Cervix; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F8 (E2F8) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC1A5 gene in lung cancer condition			[26]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Studied Phenotype	Lung cancer [ICD11: 2C25]
Tissue	Bronchus
Related DT Changes	Down regulating
Experimental Material	Human bronchus epithelial cells (16HBE14o-)
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to repress the transcription of SLC1A5 gene in lung cancer condition, which leads to a decreased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
FOXK1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Forkhead box protein K1		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein K1 (FOXK1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
FOXO3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in tumorigenesis condition			[27]
TF Protein Name	Forkhead box protein O3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein O3 (FOXO3) has been reported to activate the transcription of SLC1A5 gene in tumorigenesis condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
FOXP1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC1A5 gene in health condition			[28]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC1A5 gene in health condition, which leads to a decreased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TFDP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Transcription factor Dp-1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Dp-1 (TFDP1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 11 TF(s) Regulating This DT
EHF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	ETS homologous factor		Transcription Factor Info
Tissue	Bronchus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS homologous factor (EHF) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ELF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Colon; Liver; Lung; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ELK3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A5 gene in hypoxia condition			[29]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC1A5 gene in hypoxia condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Direct binding to SLC1A5 gene			[5]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Tissue	Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ELK4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	ETS domain-containing protein Elk-4		Transcription Factor Info
Tissue	Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS domain-containing protein Elk-4 (ELK4) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
ETS2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Protein C-ets-2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-2 (ETS2) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Liver; Lung; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
SPDEF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	SAM pointed domain-containing Ets transcription factor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	SAM pointed domain-containing Ets transcription factor (SPDEF) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
SPI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A5 gene in K562 cells			[30]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC1A5 gene in K562 cells, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Binding to SLC1A5 gene in APL condition			[31]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC1A5 gene in acute promyelocytic leukemia (APL) condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class3.6: TEA domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
TEAD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in angiogenesis condition			[32]
TF Protein Name	Transcriptional enhancer factor TEF-1		Transcription Factor Info
Studied Phenotype	Angiogenesis [ICD11: N.A.]
Tissue	Umbilical vein
Related DT Changes	Up regulating
Experimental Material	Human umbilical vein endothelial cell isolates
Detailed Description	Transcriptional enhancer factor TEF-1 (TEAD1) has been reported to activate the transcription of SLC1A5 gene in angiogenesis condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TEAD2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in angiogenesis condition			[32]
TF Protein Name	Transcriptional enhancer factor TEF-4		Transcription Factor Info
Studied Phenotype	Angiogenesis [ICD11: N.A.]
Tissue	Umbilical vein
Related DT Changes	Up regulating
Experimental Material	Human umbilical vein endothelial cell isolates
Detailed Description	Transcriptional enhancer factor TEF-4 (TEAD2) has been reported to activate the transcription of SLC1A5 gene in angiogenesis condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TEAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in angiogenesis condition			[32]
TF Protein Name	Transcriptional enhancer factor TEF-3		Transcription Factor Info
Studied Phenotype	Angiogenesis [ICD11: N.A.]
Tissue	Umbilical vein
Related DT Changes	Up regulating
Experimental Material	Human umbilical vein endothelial cell isolates
Detailed Description	Transcriptional enhancer factor TEF-3 (TEAD4) has been reported to activate the transcription of SLC1A5 gene in angiogenesis condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
NFYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Nuclear transcription factor Y subunit beta		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit beta (NFYB) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.3: SAND domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GMEB2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Glucocorticoid modulatory element-binding protein 2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Glucocorticoid modulatory element-binding protein 2 (GMEB2) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[5]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A5 gene in epithelial to mesenchymal transition condition			[33]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC1A5 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Transcriptional Phenomenon2	Binding to SLC1A5 gene in health condition			[34]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC1A5 gene in health condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC1A5 gene in megakaryocytes condition			[15]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC1A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC1A5 gene in prostate cancer condition			[35]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC1A5 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
RUNX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Runt-related transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Brain; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[3]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
REPIN1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[4]
TF Protein Name	Replication initiator 1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Replication initiator 1 (REPIN1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.
SETDB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC1A5 gene			[6]
TF Protein Name	Histone-lysine N-methyltransferase SETDB1		Transcription Factor Info
Tissue	Bone; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Histone-lysine N-methyltransferase SETDB1 (SETDB1) can directly bind to the SLC1A5 gene, which in turn affects the expression or function of the drug transporter Alanine/serine/cysteine/threonine transporter 2.

References
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