General Information of Drug Transporter (DT)
DT ID DTD0055 Transporter Info
Gene Name ABCB9
Transporter Name TAP-like protein
Gene ID
23457
UniProt ID
Q9NP78

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 15 TF(s) Regulating This DT

        ATF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Cyclic AMP-dependent transcription factor ATF-1 Transcription Factor Info

Tissue

Bone marrow; Liver

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Cyclic AMP-dependent transcription factor ATF-1 (ATF1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ATF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Cyclic AMP-dependent transcription factor ATF-2 Transcription Factor Info

Tissue

Embryo

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Cyclic AMP-dependent transcription factor ATF-2 (ATF2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        BACH2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Transcription regulator protein BACH2 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription regulator protein BACH2 (BACH2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

Embryo

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        CEBPD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

CCAAT/enhancer-binding protein delta Transcription Factor Info

Tissue

Aorta

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

Bone marrow; Embryo; Liver; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        FOSL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Fos-related antigen 1 Transcription Factor Info

Tissue

Bone marrow; Breast; Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Fos-related antigen 1 (FOSL1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        FOSL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Fos-related antigen 2 Transcription Factor Info

Tissue

Brain; Breast; Liver; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Fos-related antigen 2 (FOSL2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        JUNB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Transcription factor JunB Transcription Factor Info

Tissue

Aorta

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor JunB (JUNB) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Transcription factor JunD Transcription Factor Info

Tissue

Blood; Bone marrow; Brain; Breast; Cervix; Colon; Coronary artery; Embryo; Liver; Lung; Prostate

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor JunD (JUND) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        MAFF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Transcription factor MafF Transcription Factor Info

Tissue

Bone marrow; Liver

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor MafF (MAFF) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        MAFK 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Transcription factor MafK Transcription Factor Info

Tissue

Blood; Bone marrow; Liver; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor MafK (MAFK) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        NFE2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Transcription factor NF-E2 45 kDa subunit Transcription Factor Info

Tissue

Blood; Bone marrow; Liver

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 13 TF(s) Regulating This DT

        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Aryl hydrocarbon receptor Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Aryl hydrocarbon receptor (AHR) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ARNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Achaete-scute homolog 1 Transcription Factor Info

Tissue

Embryo; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Achaete-scute homolog 1 (ASCL1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        BHLHE40 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Class E basic helix-loop-helix protein 40 Transcription Factor Info

Tissue

Blood; Bone marrow; Liver

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        LYL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Protein lyl-1 Transcription Factor Info

Tissue

Blood; Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Protein lyl-1 (LYL1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of ABCB9 gene in melanoma condition [5]

TF Protein Name

Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of ABCB9 gene in melanoma condition, which leads to an increased expression of the drug transporter TAP-like protein.

        MXI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Max-interacting protein 1 Transcription Factor Info

Tissue

Bone marrow; Brain; Cervix; Embryo; Liver; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Max-interacting protein 1 (MXI1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Myoblast determination protein 1 Transcription Factor Info

Tissue

Myotube

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Myoblast determination protein 1 (MYOD1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        TCF12 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Transcription factor 12 Transcription Factor Info

Tissue

Blood; Brain; Embryo; Lung; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor 12 (TCF12) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Transcription factor E2-alpha Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2-alpha (TCF3) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to ABCB9 gene in glioblastoma multiforme condition [6]

TF Protein Name

Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

Temozolomide

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Transcription factor 4 (TCF4) has been reported to bind to the transcription of ABCB9 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter TAP-like protein.

        TFAP4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Transcription factor AP-4 Transcription Factor Info

Tissue

Blood; Prostate

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor AP-4 (TFAP4) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        USF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Upstream stimulatory factor 2 Transcription Factor Info

Tissue

Cervix

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Upstream stimulatory factor 2 (USF2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to ABCB9 gene in MCF7 cells [7]

TF Protein Name

Transcription factor AP-2-alpha Transcription Factor Info

Related DT Changes

Direct regulating

Detailed Description

Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of ABCB9 gene in MCF7 cells, which leads to an affected expression of the drug transporter TAP-like protein.

       Transcriptional Phenomenon2

Direct binding to ABCB9 gene [1]

TF Protein Name

Transcription factor AP-2-alpha Transcription Factor Info

Tissue

Breast; Cervix; Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor AP-2-alpha (TFAP2A) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Transcription factor AP-2 gamma Transcription Factor Info

Tissue

Breast; Cervix; Skin

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor AP-2 gamma (TFAP2C) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Estrogen receptor Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Estrogen receptor (ESR1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        HNF4G 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Hepatocyte nuclear factor 4-gamma Transcription Factor Info

Tissue

Liver

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Hepatocyte nuclear factor 4-gamma (HNF4G) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

COUP transcription factor 2 Transcription Factor Info

Tissue

Bone marrow; Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

COUP transcription factor 2 (NR2F2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        RXRG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Retinoic acid receptor RXR-gamma Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Erythroid transcription factor Transcription Factor Info

Tissue

Blood; Bone marrow

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Erythroid transcription factor (GATA1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        GATA3 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to ABCB9 gene in breast cancer condition [8]

TF Protein Name

Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of ABCB9 gene in breast cancer condition, which leads to an affected expression of the drug transporter TAP-like protein.

       Transcriptional Phenomenon2

Direct binding to ABCB9 gene [2]

TF Protein Name

Trans-acting T-cell-specific transcription factor GATA-3 Transcription Factor Info

Tissue

Blood; Brain; Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 15 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Transcriptional repressor CTCF Transcription Factor Info

Tissue

Brain

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcriptional repressor CTCF (CTCF) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Early growth response protein 1 Transcription Factor Info

Tissue

Blood; Bone marrow; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Early growth response protein 1 (EGR1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        HINFP 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Histone H4 transcription factor Transcription Factor Info

Tissue

Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Histone H4 transcription factor (HINFP) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Krueppel-like factor 1 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Krueppel-like factor 1 (KLF1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Krueppel-like factor 4 Transcription Factor Info

Tissue

Breast; Foreskin; Pancreatic ductal; Skin

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Krueppel-like factor 4 (KLF4) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Krueppel-like factor 5 Transcription Factor Info

Tissue

Colon; Pancreatic ductal; Stomach

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Krueppel-like factor 5 (KLF5) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Krueppel-like factor 9 (KLF9) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Myc-associated zinc finger protein Transcription Factor Info

Tissue

Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Myc-associated zinc finger protein (MAZ) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        SNAI2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Zinc finger protein SNAI2 Transcription Factor Info

Tissue

Embryo

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Zinc finger protein SNAI2 (SNAI2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        SP4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Transcription factor Sp4 Transcription Factor Info

Tissue

Embryo

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor Sp4 (SP4) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of ABCB9 gene in podocyte condition [9]

TF Protein Name

Wilms tumor protein Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Wilms tumor protein (WT1) has been reported to activate the transcription of ABCB9 gene in podocyte condition, which leads to an increased expression of the drug transporter TAP-like protein.

        YY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Transcriptional repressor protein YY1 Transcription Factor Info

Tissue

Blood; Bone marrow; Brain; Colon; Embryo; Liver; Lung; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcriptional repressor protein YY1 (YY1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

Bone marrow; Liver; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Zinc finger protein 263 Transcription Factor Info

Tissue

Bone marrow; Kidney

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Zinc finger protein 263 (ZNF263) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ZNF384 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Zinc finger protein 384 Transcription Factor Info

Tissue

Bone marrow

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Zinc finger protein 384 (ZNF384) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        CUX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of ABCB9 gene in multiple human cancer types condition [10]

TF Protein Name

Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of ABCB9 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter TAP-like protein.

        NKX2-1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Homeobox protein Nkx-2.1 Transcription Factor Info

Tissue

Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Homeobox protein Nkx-2.1 (NKX2-1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        PBX1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of ABCB9 gene in ovarian cancer condition [11]

TF Protein Name

Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of ABCB9 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter TAP-like protein.

       Transcriptional Phenomenon2

Direct binding to ABCB9 gene [3]

TF Protein Name

Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Tissue

Bone marrow

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        PBX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Pre-B-cell leukemia transcription factor 3 Transcription Factor Info

Tissue

Blood; Brain; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        POU2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

POU domain, class 2, transcription factor 1 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

      Class3.2: Paired box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PAX5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Paired box protein Pax-5 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Paired box protein Pax-5 (PAX5) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 11 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Transcription factor E2F1 Transcription Factor Info

Tissue

Mesenchymal

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2F1 (E2F1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        E2F3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Transcription factor E2F3 Transcription Factor Info

Tissue

Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2F3 (E2F3) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        E2F4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to ABCB9 gene in health condition [12]

TF Protein Name

Transcription factor E2F4 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of ABCB9 gene in health condition, which leads to an affected expression of the drug transporter TAP-like protein.

        E2F6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Transcription factor E2F6 Transcription Factor Info

Tissue

Bone marrow; Embryo; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2F6 (E2F6) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        E2F7 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Transcription factor E2F7 Transcription Factor Info

Tissue

Colon; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2F7 (E2F7) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        E2F8 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Transcription factor E2F8 Transcription Factor Info

Tissue

Cervix; Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2F8 (E2F8) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

Embryo; Endoderm; Liver; Lung; Skin

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        FOXP1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Repression of ABCB9 gene in embryonic stem cell condition [13]

TF Protein Name

Forkhead box protein P1 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Down regulating

Detailed Description

Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of ABCB9 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter TAP-like protein.

       Transcriptional Phenomenon2

Direct binding to ABCB9 gene [1]

TF Protein Name

Forkhead box protein P1 Transcription Factor Info

Tissue

Embryo; Prostate

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Forkhead box protein P1 (FOXP1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        FOXP2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Forkhead box protein P2 Transcription Factor Info

Tissue

Brain

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Forkhead box protein P2 (FOXP2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        TFDP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Transcription factor Dp-1 Transcription Factor Info

Tissue

Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor Dp-1 (TFDP1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 11 TF(s) Regulating This DT

        ELK1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

ETS domain-containing protein Elk-1 Transcription Factor Info

Tissue

Bone marrow; Cervix

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

ETS domain-containing protein Elk-1 (ELK1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ELK3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

ETS domain-containing protein Elk-3 Transcription Factor Info

Tissue

Vein

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

ETS domain-containing protein Elk-3 (ELK3) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ELK4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

ETS domain-containing protein Elk-4 Transcription Factor Info

Tissue

Cervix; Kidney

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

ETS domain-containing protein Elk-4 (ELK4) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Transcriptional regulator ERG Transcription Factor Info

Tissue

Aorta

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcriptional regulator ERG (ERG) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Protein C-ets-1 Transcription Factor Info

Tissue

Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Protein C-ets-1 (ETS1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        ETS2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Protein C-ets-2 Transcription Factor Info

Tissue

Colon

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Protein C-ets-2 (ETS2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to ABCB9 gene in megakaryocytes condition [14]

TF Protein Name

Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

Direct regulating

Detailed Description

Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of ABCB9 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter TAP-like protein.

       Transcriptional Phenomenon2

Direct binding to ABCB9 gene [4]

TF Protein Name

Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

Blood; Mesenchymal; Umbilical cord blood; Vein

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

GA-binding protein alpha chain Transcription Factor Info

Tissue

Blood; Bone; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

GA-binding protein alpha chain (GABPA) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Interferon regulatory factor 1 Transcription Factor Info

Tissue

Aorta

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Interferon regulatory factor 1 (IRF1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Transcriptional activator Myb Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcriptional activator Myb (MYB) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Transcription factor PU.1 Transcription Factor Info

Tissue

Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor PU.1 (SPI1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        KDM5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Lysine-specific demethylase 5B Transcription Factor Info

Tissue

Bone marrow; Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Lysine-specific demethylase 5B (KDM5B) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.2: Heteromeric CCAAT-binding factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NFYA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Nuclear transcription factor Y subunit alpha Transcription Factor Info

Tissue

Bone marrow

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Transcription factor COE1 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor COE1 (EBF1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        RELA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to ABCB9 gene in fibrosarcoma condition [15]

TF Protein Name

Transcription factor p65 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Transcription factor p65 (RELA) has been reported to bind to the transcription of ABCB9 gene in fibrosarcoma condition, which leads to an affected expression of the drug transporter TAP-like protein.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TP53 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to ABCB9 gene in health condition [16]

TF Protein Name

Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of ABCB9 gene in health condition, which leads to an affected expression of the drug transporter TAP-like protein.

       Transcriptional Phenomenon2

Binding to ABCB9 gene in tumorigenesis condition [17]

TF Protein Name

Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of ABCB9 gene in tumorigenesis condition, which leads to an affected expression of the drug transporter TAP-like protein.

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to ABCB9 gene in epithelial to mesenchymal transition condition [18]

TF Protein Name

Tumor protein 63 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCB9 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter TAP-like protein.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to ABCB9 gene in megakaryocytes condition [14]

TF Protein Name

Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

Direct regulating

Detailed Description

Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of ABCB9 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter TAP-like protein.

       Transcriptional Phenomenon2

Direct binding to ABCB9 gene [4]

TF Protein Name

Runt-related transcription factor 1 Transcription Factor Info

Tissue

Blood; Bone; Bone marrow; Umbilical cord blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Runt-related transcription factor 1 (RUNX1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of ABCB9 gene in prostate cancer condition [19]

TF Protein Name

Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of ABCB9 gene in prostate cancer condition, which leads to an increased expression of the drug transporter TAP-like protein.

        RUNX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Runt-related transcription factor 3 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Runt-related transcription factor 3 (RUNX3) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

      Class6.7: Grainyhead domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GRHL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Grainyhead-like protein 2 homolog Transcription Factor Info

Tissue

Breast; Bronchus; Ovary

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        GRHL3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Grainyhead-like protein 3 homolog Transcription Factor Info

Tissue

Skin

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Grainyhead-like protein 3 homolog (GRHL3) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NFIC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Nuclear factor 1 C-type Transcription Factor Info

Tissue

Blood; Brain; Uterus

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Nuclear factor 1 C-type (NFIC) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

TF Superclass8: beta-Sheet binding to DNA

      Class8.1: TATA-binding proteins

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TBP 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

TATA-box-binding protein Transcription Factor Info

Tissue

Blood; Bone marrow; Cervix; Embryo; Liver

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

TATA-box-binding protein (TBP) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

TF Superclass10: Yet undefined DNA-binding domains

      Class10: Uncharacterized

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NRF1 

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       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [1]

TF Protein Name

Nuclear respiratory factor 1 Transcription Factor Info

Tissue

Bone marrow; Brain; Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Nuclear respiratory factor 1 (NRF1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

      Class10.1: Other factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        GTF2B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [2]

TF Protein Name

Transcription initiation factor IIB Transcription Factor Info

Tissue

Cervix; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription initiation factor IIB (GTF2B) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        MBD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [3]

TF Protein Name

Methyl-CpG-binding domain protein 3 Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Methyl-CpG-binding domain protein 3 (MBD3) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.

        SETDB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to ABCB9 gene [4]

TF Protein Name

Histone-lysine N-methyltransferase SETDB1 Transcription Factor Info

Tissue

Bone marrow

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Histone-lysine N-methyltransferase SETDB1 (SETDB1) can directly bind to the ABCB9 gene, which in turn affects the expression or function of the drug transporter TAP-like protein.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-325. (ID:ENSG00000150967)
5 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
6 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
7 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
8 Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
9 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
10 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
11 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
12 Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
13 An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
14 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
15 Modulation of gene expression regulated by the transcription factor NF-B/RelA. J Biol Chem. 2014;289(17):11927-11944.
16 Distinct p53 genomic binding patterns in normal and cancer-derived human cells. Cell Cycle. 2011;10(24):4237-49.
17 A global map of p53 transcription-factor binding sites in the human genome. Cell. 2006;124(1):207-19.
18 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
19 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.

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