Microbe Species Information | VARIDT

General Information of This Microbe species
Species ID	MIC00089
Species Name	Streptococcus pyogenes
Taxonomy ID	1314
Lineage	Kingdom:Bacteria Phylum:Bacillota Class:Bacilli Order:Lactobacillales Family:Streptococcaceae Genus: Streptococcus Species: Streptococcus pyogenes

Drug Transporter(s) Regulated by This Microbe species
Class1: Microbiota direct bioaccumulation of drugs
FLVCR1	Transporter Info	Health [ICD11: N.A]			[1], [2], [3], [4]
NRAMP2	Transporter Info	Bacterial pneumonia [ICD11: A40.0]			[5], [6], [7], [8]
SLC48A1	Transporter Info	Health [ICD11: N.A]			[1], [2], [3], [4]
SLC49A2	Transporter Info	Health [ICD11: N.A]			[1], [2], [3], [4]
ZNT1	Transporter Info	Health [ICD11: N.A]			[9], [10], [11], [12]
ZNT10	Transporter Info	Health [ICD11: N.A]			[9], [10], [11], [12]
ZNT2	Transporter Info	Health [ICD11: N.A]			[9], [10], [11], [12]
ZNT3	Transporter Info	Health [ICD11: N.A]			[9], [10], [11], [12]
ZNT4	Transporter Info	Health [ICD11: N.A]			[9], [10], [11], [12]
ZNT5	Transporter Info	Health [ICD11: N.A]			[9], [10], [11], [12]
ZNT6	Transporter Info	Health [ICD11: N.A]			[9], [10], [11], [12]
ZNT7	Transporter Info	Health [ICD11: N.A]			[9], [10], [11], [12]
ZNT8	Transporter Info	Health [ICD11: N.A]			[9], [10], [11], [12]
ZNT9	Transporter Info	Health [ICD11: N.A]			[9], [10], [11], [12]

References
1	Sequestration and scavenging of iron in infection. Infect Immun. 2013 Oct;81(10):3503-14.
2	Identification and characterization of a Streptococcus pyogenes operon involved in binding of hemoproteins and acquisition of iron. Infect Immun. 2003 Mar;71(3):1042-55.
3	Heme Mobilization in Animals: A Metallolipid's Journey. Acc Chem Res. 2016 Jun 21;49(6):1104-10.
4	Handling heme: The mechanisms underlying the movement of heme within and between cells. Free Radic Biol Med. 2019 Mar;133:88-100.
5	Manganese homeostasis and utilization in pathogenic bacteria. Mol Microbiol. 2015 Jul;97(2):216-28.
6	Manganese transport and the role of manganese in virulence. Annu Rev Microbiol. 2006;60:187-209.
7	A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3449-54.
8	MtsABC is important for manganese and iron transport, oxidative stress resistance, and virulence of Streptococcus pyogenes. Infect Immun. 2003 May;71(5):2656-64.
9	Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. Front Cell Infect Microbiol. 2014 Jan 24;4:2.
10	Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses. Arch Biochem Biophys. 2016 Dec 1;611:66-78.
11	Transition metals and host-microbe interactions in the inflamed intestine. Biometals. 2019 Jun;32(3):369-384.
12	An antimicrobial role for zinc in innate immune defense against group A streptococcus. J Infect Dis. 2014 May 15;209(10):1500-8.

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