Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0533 Transporter Info
Gene Name ATP7B
Transporter Name Copper-transporting ATPase 2
Gene ID
540
UniProt ID
P35670
Microbiota Influence of This DT (MBI)

Bacteria: Actinomycetota

   Genus: Mycobacterium

     Mycobacterium tuberculosis 

Microbe Info

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       Microbe Influence1

 Co-transport of human ATP7B substrates/drugs in the health condition [1], [2], [3], [4]

Regulating Factor
ctpV

Detailed Description

 The protein ctpV of Mycobacterium tuberculosis GC1237 has been reported to transport similar substrates/drugs of ATP7B, which affects the distribution of its substrate/drug in vivo.

Bacteria: Bacillota

   Genus: Streptococcus

     Streptococcus pneumoniae 

Microbe Info

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       Microbe Influence1

 Sequestration of human ATP7B substrates/drugs in the health condition [2], [4], [5], [6]

Regulating Factor
cupA

Detailed Description

 The protein cupA of Streptococcus pneumoniae TIGR4 has been reported to sequester the substrate/drug of ATP7B, which may affects its substrate/drug distribution in the body.

Bacteria: Pseudomonadota

   Genus: Escherichia

     Escherichia coli 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human ATP7B substrates/drugs in the health condition [2], [4], [5], [7]

Regulating Factor
copA

Detailed Description

 The protein copA of Escherichia coli str. K-12 substr. W3110 has been reported to sequester the substrate/drug of ATP7B, which may affects its substrate/drug distribution in the body.

       Microbe Influence2

 Sequestration of human ATP7B substrates/drugs in the health condition [2], [4], [5], [7]

Regulating Factor
corZ

Detailed Description

 The protein corZ of Escherichia coli str. K-12 substr. W3110 has been reported to sequester the substrate/drug of ATP7B, which may affects its substrate/drug distribution in the body.

   Genus: Pseudomonas

     Pseudomonas aeruginosa 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human ATP7B substrates/drugs in the health condition [2], [4], [5], [8]

Regulating Factor
copZ1

Detailed Description

 The protein copZ1 of Pseudomonas aeruginosa PAO1 has been reported to sequester the substrate/drug of ATP7B, which may affects its substrate/drug distribution in the body.

   Genus: Rhodobacter

     Rhodobacter capsulatus 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Sequestration of human ATP7B substrates/drugs in the health condition [2], [4], [5], [9]

Regulating Factor
corA

Detailed Description

 The protein corA of Rhodobacter capsulatus MT1131 has been reported to sequester the substrate/drug of ATP7B, which may affects its substrate/drug distribution in the body.
References
1 Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses. Arch Biochem Biophys. 2016 Dec 1;611:66-78.
2 Cu Homeostasis in Bacteria: The Ins and Outs. Membranes (Basel). 2020 Sep 18;10(9):242.
3 A novel P(1B)-type Mn2+-transporting ATPase is required for secreted protein metallation in mycobacteria. J Biol Chem. 2013 Apr 19;288(16):11334-47.
4 Human copper transporters: mechanism, role in human diseases and therapeutic potential. Future Med Chem. 2009 Sep;1(6):1125-42.
5 Trace metals and animal health: Interplay of the gut microbiota with iron, manganese, zinc, and copper. Anim Nutr. 2021 Sep;7(3):750-761.
6 Copper Chaperone CupA and Zinc Control CopY Regulation of the Pneumococcal cop Operon. mSphere. 2017 Oct 18;2(5):e00372-17.
7 One gene, two proteins: coordinated production of a copper chaperone by differential transcript formation and translational frameshifting in Escherichia coli. Mol Microbiol. 2017 Nov;106(4):635-645.
8 The interplay of the metallosensor CueR with two distinct CopZ chaperones defines copper homeostasis in Pseudomonas aeruginosa. J Biol Chem. 2019 Mar 29;294(13):4934-4945.
9 The Cu chaperone CopZ is required for Cu homeostasis in Rhodobacter capsulatus and influences cytochrome cbb3 oxidase assembly. Mol Microbiol. 2019 Mar;111(3):764-783.

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