Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0354 Transporter Info
Gene Name SLC41A1
Transporter Name Magnesium transporter protein solute carrier family 41 member 1
Gene ID
254428
UniProt ID
Q8IVJ1
Microbiota Influence of This DT (MBI)

Bacteria: Bacillota

   Genus: Alkalihalophilus

     Alkalihalophilus pseudofirmus 

Microbe Info

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       Microbe Influence1

 Co-transport of human SLC41A1 substrates/drugs in the health condition [1], [2], [3], [4], [5]

Regulating Factor
mgtE

Detailed Description

 The protein mgtE of Alkalihalophilus pseudofirmus OF4 has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

Bacteria: Deinococcota

   Genus: Thermus

     Thermus thermophilus 

Microbe Info

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       Microbe Influence1

 Co-transport of human SLC41A1 substrates/drugs in the health condition [6], [5]

Regulating Factor
mgtE

Detailed Description

 The protein mgte of Thermus thermophilus has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

Bacteria: Pseudomonadota

   Genus: Escherichia

     Escherichia coli 

Microbe Info

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       Microbe Influence1

 Co-transport of human SLC41A1 substrates/drugs in the health condition [7], [8], [5]

Regulating Factor
mgtA

Detailed Description

 The protein mgtA of Escherichia coli BL21(DE3) has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Providencia

     Providencia stuartii 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC41A1 substrates/drugs in the health condition [1], [9], [10], [5]

Regulating Factor
mgtE

Detailed Description

 The protein mgte of Providencia stuartii has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Salmonella

     Salmonella enterica 

Microbe Info

Click to Show/Hide the Full List 8 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC41A1 substrates/drugs in the health condition [1], [5], [8], [11], [12]

Regulating Factor
mgtA

Detailed Description

 The protein mgtA of Salmonella enterica subsp. enterica serovar Typhimurium TN1379 has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Co-transport of human SLC41A1 substrates/drugs in the health condition [1], [5], [8], [11], [13]

Regulating Factor
mgtA

Detailed Description

 The protein mgtA of Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence3

 Co-transport of human SLC41A1 substrates/drugs in the health condition [1], [2], [5], [8], [14], [15]

Regulating Factor
mgtA

Detailed Description

 The protein mgtA of Salmonella enterica subsp. enterica serovar Typhimurium TN2540 has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence4

 Co-transport of human SLC41A1 substrates/drugs in the health condition [1], [2], [5], [8], [14], [16]

Regulating Factor
mgtA

Detailed Description

 The protein mgtA of Salmonella enterica subsp. enterica serovar Typhimurium TN1010 has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence5

 Co-transport of human SLC41A1 substrates/drugs in the health condition [1], [11], [12], [8], [5]

Regulating Factor
mgtB

Detailed Description

 The protein mgtB of Salmonella enterica subsp. enterica serovar Typhimurium TN1379 has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence6

 Co-transport of human SLC41A1 substrates/drugs in the health condition [1], [2], [5], [8], [14], [17]

Regulating Factor
mgtB

Detailed Description

 The protein mgtB of Salmonella enterica subsp. enterica serovar Typhimurium has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence7

 Co-transport of human SLC41A1 substrates/drugs in the health condition [1], [2], [5], [8], [14], [16]

Regulating Factor
mgtB

Detailed Description

 The protein mgtB of Salmonella enterica subsp. enterica serovar Typhimurium TN1010 has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence8

 Co-transport of human SLC41A1 substrates/drugs in the health condition [1], [11], [13], [8], [5]

Regulating Factor
MgtBC ,

Detailed Description

 The protein MgtBC of Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Yersinia

     Yersinia pestis 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC41A1 substrates/drugs in the health condition [18], [8], [5]

Regulating Factor
mgtA

Detailed Description

 The protein mgtA of Yersinia pestis KIM6 has been reported to transport similar substrates/drugs of SLC41A1, which affects the distribution of its substrate/drug in vivo.
References
1 Transport of magnesium by a bacterial Nramp-related gene. PLoS Genet. 2014 Jun 26;10(6):e1004429.
2 The structure of CorA: a Mg(2+)-selective channel. Curr Opin Struct Biol. 2006 Aug;16(4):432-8.
3 Genes for magnesium transport. Curr Opin Plant Biol. 2003 Jun;6(3):263-7.
4 Cloning and characterization of MgtE, a putative new class of Mg2+ transporter from Bacillus firmus OF4. J Bacteriol. 1995 Mar;177(5):1233-8.
5 The bacterial magnesium transporter CorA can functionally substitute for its putative homologue Mrs2p in the yeast inner mitochondrial membrane. J Biol Chem. 1999 Jul 16;274(29):20438-43.
6 Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg2+ channel MgtE. Nat Commun. 2014 Nov 4;5:5374.
7 The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro. Elife. 2016 Jan 18;5:e11407.
8 The SLC41 family of MgtE-like magnesium transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):620-8.
9 Structure, properties and regulation of magnesium transport proteins. Biometals. 2002 Sep;15(3):261-70.
10 Cloning of the mgtE Mg2+ transporter from Providencia stuartii and the distribution of mgtE in gram-negative and gram-positive bacteria. J Bacteriol. 1995 Sep;177(18):5350-4.
11 Microbial magnesium transport: unusual transporters searching for identity. Mol Microbiol. 1998 Apr;28(2):217-26.
12 Magnesium transport in Salmonella typhimurium: 28Mg2+ transport by the CorA, MgtA, and MgtB systems. J Bacteriol. 1989 Sep;171(9):4761-6.
13 Molecular basis of the magnesium deprivation response in Salmonella typhimurium: identification of PhoP-regulated genes. J Bacteriol. 1996 Sep;178(17):5092-9.
14 Functional similarity between archaeal and bacterial CorA magnesium transporters. J Bacteriol. 1998 May;180(10):2788-91.
15 Magnesium transport in Salmonella typhimurium: mgtA encodes a P-type ATPase and is regulated by Mg2+ in a manner similar to that of the mgtB P-type ATPase. J Bacteriol. 1995 May;177(10):2654-62.
16 Magnesium transport in Salmonella typhimurium: genetic characterization and cloning of three magnesium transport loci. J Bacteriol. 1989 Sep;171(9):4742-51.
17 The mgtB Mg2+ transport locus of Salmonella typhimurium encodes a P-type ATPase. J Biol Chem. 1991 Jan 15;266(2):815-23.
18 Transcription factor function and promoter architecture govern the evolution of bacterial regulons. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4319-24.

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