Modelled Stucture
Method:Homology modeling
Teplate PDB:6JPA_C
Identity:72.951%
Minimized Score:-919.207
Detail: Structure Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0535 Transporter Info | ||||
| Gene Name | CACNB2 | ||||
| Protein Name | Voltage-dependent L-type calcium channel beta-2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Mus musculus (Mouse) | |||||
| Gene Name | Cacnb2 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6JPA_C Sequence Length:439 Identity:77.13% |
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| Performance | Minimized Score | -829.583 kcal/mol | |||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-0.78 ±0.4 Residues in Favored Region:420 Ramachandran favored:96.11% Number of Outliers:1 Ramachandran outliers:0.23% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.73 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| Rattus norvegicus (Rat) | |||||
| Gene Name | Cacnb2 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure | |||||
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| Experimental Structures of This Model Oganism | |||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref |
| 1T0H | X-ray | 1.97 Å | Escherichia coli | [ 1] | |
| Structure | |||||
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| Corresponding chain | A/B | ||||
| Sequence Length | 68-196; 254-476 | Mutation | Yes | ||
| 5V2P | X-ray | 2 Å | Escherichia coli | [ 2] | |
| Structure | |||||
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| Corresponding chain | A | ||||
| Sequence Length | 68-189; 254-476 | Mutation | Yes | ||
| 5V2Q | X-ray | 1.7 Å | Escherichia coli | [ 2] | |
| Structure | |||||
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| Corresponding chain | A | ||||
| Sequence Length | 68-189; 254-476 | Mutation | Yes | ||
| 3JBR | EM | 4.2 Å | Escherichia coli | [ 3] | |
| Structure | |||||
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| Corresponding chain | B | ||||
| Sequence Length | 68-196; 254-475 | Mutation | No | ||
| Oryctolagus cuniculus (Rabbit) | |||||
| Gene Name | CACNB2 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6JPA_C Sequence Length:438 Identity:77.303% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -799.923 kcal/mol | |||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:0.02 ±0.38 Residues in Favored Region:417 Ramachandran favored:95.64% Number of Outliers:1 Ramachandran outliers:0.23% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.73 |
||||
| Click to Save Local Quality Plot in PNG Format | |||||
| Experimental Structures of This Model Oganism | |||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref |
| 4DEX | X-ray | 2 Å | Escherichia coli | [ 4] | |
| Structure | |||||
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| Corresponding chain | A | ||||
| Sequence Length | 51-163; 229-448 | Mutation | No | ||
| 4DEY | X-ray | 1.95 Å | Escherichia coli | [ 4] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | A | ||||
| Sequence Length | 51-163; 229-448 | Mutation | No | ||
| 1T3L | X-ray | 2.2 Å | Escherichia coli | [ 5] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | A | ||||
| Sequence Length | 51-163; 229-448 | Mutation | Yes | ||
| 1T3S | X-ray | 2.3 Å | Escherichia coli | [ 5] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | A | ||||
| Sequence Length | 51-163; 229-422 | Mutation | Yes | ||
| References | |||||
| 1 | Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature. 2004 Jun 10;429(6992):671-5. | ||||
| 2 | Stapled Voltage-Gated Calcium Channel (Ca(V)) -Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of Ca(V) Function. ACS Chem Neurosci. 2017 Jun 21;8(6):1313-1326. | ||||
| 3 | Structure of the voltage-gated calcium channel Cav1.1 complex. Science. 2015 Dec 18;350(6267):aad2395. | ||||
| 4 | The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis. J Neurosci. 2012 May 30;32(22):7602-13. | ||||
| 5 | Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha 1 interaction domain. Neuron. 2004 May 13;42(3):387-99. | ||||
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