General Information of Drug Transporter (DT)
DT ID	DTD0535 Transporter Info
Gene Name	CACNB2
Transporter Name	Voltage-dependent L-type calcium channel beta-2
Gene ID	783
UniProt ID	Q08289
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	6JPA_C		Identity	72.951%
Performance	Minimized Score	-919.207 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	Medium
Ramachandran Plot
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	Ramz Z Score	0.24 ±0.37
	Residues in Favored Region	466	Ramachandran favored	97.49%
	Number of Outliers	4	Ramachandran outliers	0.84%
Local Quality
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	QMEANBrane Score		0.72
AlphaFold Protein Structure Database	Q08289 Click to jump to the details page
SWISS-MODEL Database	Q08289 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
8HLP	EM	3.5 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	C
Sequence Length	632		Mutation	No
8HMA	EM	3.4 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	H
Sequence Length	632		Mutation	No
8HMB	EM	3.3 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	C
Sequence Length	632		Mutation	No
References
1	Structural bases of inhibitory mechanism of Ca(V)1.2 channel inhibitors. Nat Commun. 2024;15(1):2772.

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