Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0193 Transporter Info | ||||
| Gene Name | SLC25A31 | ||||
| Protein Name | Adenine nucleotide translocator 4 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs201279313 | ||||
| Site of GPD | chr4:127735886-127735890 (GRCh38.p12) | ||||
| GPD Type | IndelInsertion and Deletion | ||||
| Allele(s) in dbSNP | delATT | ||||
| Genotype TTA/de | Click to Show/Hide the Full List of Affected Drugs: 3 Drugs in Total | ||||
| Atenolol | Drug Info | Hypertension | Correlated with the increased drug response in patienrs (compare with Genotype TTA/ttA) | [ 1] | |
| Hydrochlorothiazide | Drug Info | Hypertension | Correlated with the increased drug response in patienrs (compare with Genotype TTA/ttA) | [ 1] | |
| Metoprolol | Drug Info | Hypertension | Correlated with the increased drug response in patienrs (compare with Genotype TTA/ttA) | [ 1] | |
| Genotype TTA/del | Click to Show/Hide the Full List of Affected Drugs: 6 Drugs in Total | ||||
| Atenolol | N.A. | Diarrhea | Genotype TTA/del is associated with increased response to atenolol, hydrochlorothiazide or metoprolol in people with Hypertension as compared to genotype TTA/TTA. | [ 1] | |
| Hydrochlorothiazide | N.A. | Diarrhea | Genotype TTA/del is associated with increased response to atenolol, hydrochlorothiazide or metoprolol in people with Hypertension as compared to genotype TTA/TTA. | [ 1] | |
| Metoprolol | N.A. | Diarrhea | Genotype TTA/del is associated with increased response to atenolol, hydrochlorothiazide or metoprolol in people with Hypertension as compared to genotype TTA/TTA. | [ 1] | |
| Atenolol | N.A. | Hypertension | Genotype TTA/del is associated with increased response to atenolol, hydrochlorothiazide or metoprolol in people with Hypertension as compared to genotype TTA/TTA. | [ 1] | |
| Hydrochlorothiazide | N.A. | Hypertension | Genotype TTA/del is associated with increased response to atenolol, hydrochlorothiazide or metoprolol in people with Hypertension as compared to genotype TTA/TTA. | [ 1] | |
| Metoprolol | N.A. | Hypertension | Genotype TTA/del is associated with increased response to atenolol, hydrochlorothiazide or metoprolol in people with Hypertension as compared to genotype TTA/TTA. | [ 1] | |
| Genotype TTA/TTA | Click to Show/Hide the Full List of Affected Drugs: 3 Drugs in Total | ||||
| Atenolol | N.A. | Hypertension | Patients with the TTA/TTA genotype and hypertension may have decreased response to atenolol, hydrochlorothiazide, or metoprolol as compared to patients with the TTA/del genotype. Other genetic and clinical factors may also influence a patient's response. | [ 1] | |
| Hydrochlorothiazide | N.A. | Hypertension | Patients with the TTA/TTA genotype and hypertension may have decreased response to atenolol, hydrochlorothiazide, or metoprolol as compared to patients with the TTA/del genotype. Other genetic and clinical factors may also influence a patient's response. | [ 1] | |
| Metoprolol | N.A. | Hypertension | Patients with the TTA/TTA genotype and hypertension may have decreased response to atenolol, hydrochlorothiazide, or metoprolol as compared to patients with the TTA/del genotype. Other genetic and clinical factors may also influence a patient's response. | [ 1] | |
| Genotype del/del | Click to Show/Hide the Full List of Affected Drugs: 3 Drugs in Total | ||||
| Atenolol | N.A. | Hypertension | No patients with del/del were studied. However, patients with the del/del genotype and hypertension may have increased response to atenolol, hydrochlorothiazide, or metoprolol as compared to patients with the TTA/TTA genotype. Other genetic and clinical factors may also influence a patient's response. | [ 1] | |
| Hydrochlorothiazide | N.A. | Hypertension | No patients with del/del were studied. However, patients with the del/del genotype and hypertension may have increased response to atenolol, hydrochlorothiazide, or metoprolol as compared to patients with the TTA/TTA genotype. Other genetic and clinical factors may also influence a patient's response. | [ 1] | |
| Metoprolol | N.A. | Hypertension | No patients with del/del were studied. However, patients with the del/del genotype and hypertension may have increased response to atenolol, hydrochlorothiazide, or metoprolol as compared to patients with the TTA/TTA genotype. Other genetic and clinical factors may also influence a patient's response. | [ 1] | |
| References | |||||
| 1 | Pharmacogenomic Genome-Wide Meta-Analysis of Blood Pressure Response to -Blockers in Hypertensive African Americans. Hypertension. 2016 Mar;67(3):556-63. | ||||
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