Drug Information
| General Information | ||||||
|---|---|---|---|---|---|---|
| Drug ID |
DR00436
|
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| Drug Name |
Metoprolol
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| Synonyms |
(RS)-Metoprolol; 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol; 1-(Isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol; 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol; 1-[(1-methylethyl)amino]-3-({4-[2-(methyloxy)ethyl]phenyl}oxy)propan-2-ol; 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol; 1-[4-(2-methoxyethyl)phenoxy]-3-propan-2-ylamino-propan-2-ol; 3-[4-(2-methoxyethyl)phenoxy]-1-(propan-2-ylamino)propan-2-ol; AstraZeneca Brand of Metaoprolol Tartrate; AstraZeneca Brand of Seloken; Beatrolol; Beloc Duriles; Beloc-Duriles; BelocDuriles; Betaloc; Betaloc (TN); Betaloc Astra; Betaloc-Astra; BetalocAstra; Betalok; CGP 2175; CGP-2175; CGP2175; Corvitol (TN); Dl-Metoprolol; Dutoprol; H 93 26; H 93-26; H 9326; LOPRESSIDONE; Leiras Brand of Metoprolol Succinate or Metoprolol Tartrate; Lopresor; Lopresoretic; Lopressor; Lopressor (TN); Meijoprolol; Metohexal; Metoprolol (USAN/INN); Metoprolol [USAN:INN:BAN]; Metoprolol succinate; Metoprololum; Metoprololum [INN-Latin]; Metrol (TN); Metroprolol; Minax (TN); Neobloc (TN); Novartis Brand of Metprolol Tartrate; Preblok; Presolol; Selo-Zok; Selokeen (TN); Seloken; Seloken AstraZeneca Brand; Seroken; Spesicor; Spesikor; TOPROL-XL; Tartrate, Metoprolol; Toprol; Toprol-XL (TN)
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| Drug Type |
Small molecular drug
|
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| Indication | Angina [ICD11:BA40] | Approved | [1] | |||
| High blood pressure [ICD11:BA00] | Approved | [1] | ||||
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
|
 |
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| 3D MOL | 2D MOL | |||||
| Formula |
C15H25NO3
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| Canonical SMILES |
CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
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| InChI |
InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
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| InChIKey |
IUBSYMUCCVWXPE-UHFFFAOYSA-N
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| CAS Number |
CAS 37350-58-6
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| Pharmaceutical Properties | Molecular Weight | 267.36 | Topological Polar Surface Area | 50.7 | ||
| Heavy Atom Count | 19 | Rotatable Bond Count | 9 | |||
| Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 4 | |||
| XLogP |
1.9
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| PubChem CID | ||||||
| PubChem SID |
103164420
,104179199
,104305635
,10520685
,11533336
,117664446
,124749948
,124886734
,125349182
,126443769
,126524234
,126628938
,126639359
,126654065
,126670412
,126687042
,126732563
,128220647
,131312492
,131472906
,132210550
,134337774
,135144539
,14799183
,29223277
,46506211
,48416268
,4904669
,49698871
,50023420
,50103878
,50103879
,50103880
,53790219
,56310948
,56313025
,56413044
,57322176
,7849417
,78524559
,7979976
,81040953
,8152611
,85209393
,85789202
,92309031
,92717148
,93619457
,9411
,99234266
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| ChEBI ID |
ChEBI:6904
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| TTD Drug ID | ||||||
| DT(s) Transporting This Drug | PEPT1 | Transporter Info | Peptide transporter 1 | Substrate | [2] | |
| References | ||||||
| 1 | Metoprolol was approved by FDA. The official website of the U.S. Food and Drug Administration. (2019) | |||||
| 2 | Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. | |||||
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