Drug Transporter (DT) Information

General Information of DT
DT ID DTD0545
Gene Name KCNK2
Protein Name Potassium channel subfamily K member 2
Gene ID
3776
UniProt ID
O95069
TCDB ID
1.A.1.9.1
3D Structure

Crystal Structure

Crystallisation Method:X-ray

PDB ID:4TWK

Corresponding Chain:A/B

Sequence Length:41-315

Detail: Struture Info

Synonyms Outward rectifying potassium channel protein TREK-1; TREK-1 K(+) channel subunit; Two pore domain potassium channel TREK-1; Two pore potassium channel TPKC1
DT Family Voltage-gated Ion Channel (VIC) Superfamily ;
Tissue Specificity Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.
Function This transporter can reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. Ion channel that contributes to passive transmembrane potassium transport.
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Potassium channel subfamily K member 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Potassium channel subfamily K member 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Potassium channel subfamily K member 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Potassium channel subfamily K member 2
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Potassium channel subfamily K member 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Potassium channel subfamily K member 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Potassium channel subfamily K member 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Potassium channel subfamily K member 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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