General Information of Drug Transporter (DT)
DT ID	DTD0545 Transporter Info
Gene Name	KCNK2
Protein Name	Potassium channel subfamily K member 2
Gene ID	3776
UniProt ID	O95069
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs6686529
Site of GPD	chr1:215236763 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>C / G>T
Minor Allele Frequency	G=0.3460/684 (Global)
Genotypes CC + CG	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Sevoflurane	N.A.	Sedation	Genotypes CC + CG are associated with increased sedation when exposed to sevoflurane in people with otorhinolaryngology surgery as compared to genotype GG.		[ 1]
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Sevoflurane	N.A.	Sedation	Patients with the rs6686529 CC genotype who are treated with sevoflurane may have increased sedation as compared to patients with the GG genotype. Other genetic and clinical factors may also influence sedation.		[ 1]
Genotype CG	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Sevoflurane	N.A.	Sedation	Patients with the rs6686529 CG genotype who are treated with sevoflurane may have increased sedation as compared to patients with the GG genotype. Other genetic and clinical factors may also influence sedation.		[ 1]
Genotype GG	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Sevoflurane	N.A.	Sedation	Patients with the rs6686529 GG genotype who are treated with sevoflurane may have decreased sedation as compared to patients with the CG or CC genotypes. Other genetic and clinical factors may also influence sedation.		[ 1]
References
1	Study of the Association of Single Nucleotide Polymorphisms in Candidate Genes With Sevoflurane. J Clin Pharmacol. 2023 Jan;63(1):91-104.

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