Crystal Structure
Crystallisation Method:EM
Corresponding Chain:A
Sequence Length:2-2377
Detail: Struture Info
Drug Transporter (DT) Information
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| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0541 | ||||
| Gene Name | CACNA1G | ||||
| Protein Name | Voltage-gated calcium channel subunit alpha Cav3.1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Crystal Structure Crystallisation Method:EM Corresponding Chain:A Sequence Length:2-2377 Detail: Struture Info |
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| Synonyms | Cav3.1c; NBR13; Voltage-dependent T-type calcium channel subunit alpha-1G | ||||
| DT Family | Na+/K+/Ca2+ Channel Targeting Tarantula Huwentoxin (THT) Family ; | ||||
| Tissue Specificity | Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression. | ||||
| Function | This transporter is voltage-sensitive calcium channels (VSCC), and it mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-gated calcium channel subunit alpha Cav3.1 |
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(β) Cell Distribution Level of Voltage-gated calcium channel subunit alpha Cav3.1 |
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(γ) Organelle Distribution Level of Voltage-gated calcium channel subunit alpha Cav3.1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Voltage-gated calcium channel subunit alpha Cav3.1 |
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(γ) Transcriptional Regulation of Voltage-gated calcium channel subunit alpha Cav3.1 |
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(δ) Epigenetic Regulation of Voltage-gated calcium channel subunit alpha Cav3.1 |
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(ε) Exogenous Modulation of Voltage-gated calcium channel subunit alpha Cav3.1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(δ) Xenobiotics-regulated Structural Variability |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-gated calcium channel subunit alpha Cav3.1 |
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(β) Disease-specific Protein Abundances of Voltage-gated calcium channel subunit alpha Cav3.1 |
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(γ) Species- and Tissue-specific DT Abundances |
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If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.