Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0541 Transporter Info
Gene Name	CACNA1G
Transporter Name	Voltage-gated calcium channel subunit alpha Cav3.1
Gene ID	8913
UniProt ID	O43497

Post-Translational Modification of This DT
Overview ofCACNA1G Modification Sites with Functional and Structural Information
Sequence	M D E E E D G A G A E E S G Q P R S F M R L N D L S G A G G R P G P G S A E K D P G S A D S E A E G L P Y P A L A P V V F F Y L S Q D S R P R S W C L R T V C N P W F E R I S M L V I L L N C V T L G M F R P C E D I A C D S Q R C R I L Q A F D D F I F A F F A V E M V V K M V A L G I F G K K C Y L G D T W N R L D F F I V I A G M L E Y S L D L Q N V S F S A V R T V R V L R P L R A I N R V P S M R I L V T L L L D T L P M L G N V L L L C F F V F F I F G I V G V Q L W A G L L R N R C F L P E N F S L P L S V D L E R Y Y Q T E N E D E S P F I C S Q P R E N G M R S C R S V P T L R G D G G G G P P C G L D Y E A Y N S S S N T T C V N W N Q Y Y T N C S A G E H N P F K G A I N F D N I G Y A W I A I F Q V I T L E G W V D I M Y F V M D A H S F Y N F I Y F I L L I I V G S F F M I N L C L V V I A T Q F S E T K Q R E S Q L M R E Q R V R F L S N A S T L A S F S E P G S C Y E E L L K Y L V Y I L R K A A R R L A Q V S R A A G V R V G L L S S P A P L G G Q E T Q P S S S C S R S H R R L S V H H L V H H H H H H H H H Y H L G N G T L R A P R A S P E I Q D R D A N G S R R L M L P P P S T P A L S G A P P G G A E S V H S F Y H A D C H L E P V R C Q A P P P R S P S E A S G R T V G S G K V Y P T V H T S P P P E T L K E K A L V E V A A S S G P P T L T S L N I P P G P Y S S M H K L L E T Q S T G A C Q S S C K I S S P C L K A D S G A C G P D S C P Y C A R A G A G E V E L A D R E M P D S D S E A V Y E F T Q D A Q H S D L R D P H S R R Q R S L G P D A E P S S V L A F W R L I C D T F R K I V D S K Y F G R G I M I A I L V N T L S M G I E Y H E Q P E E L T N A L E I S N I V F T S L F A L E M L L K L L V Y G P F G Y I K N P Y N I F D G V I V V I S V W E I V G Q Q G G G L S V L R T F R L M R V L K L V R F L P A L Q R Q L V V L M K T M D N V A T F C M L L M L F I F I F S I L G M H L F G C K F A S E R D G D T L P D R K N F D S L L W A I V T V F Q I L T Q E D W N K V L Y N G M A S T S S W A A L Y F I A L M T F G N Y V L F N L L V A I L V E G F Q A E E I S K R E D A S G Q L S C I Q L P V D S Q G G D A N K S E S E P D F F S P S L D G D G D R K K C L A L V S L G E H P E L R K S L L P P L I I H T A A T P M S L P K S T S T G L G E A L G P A S R R T S S S G S A E P G A A H E M K S P P S A R S S P H S P W S A A S S W T S R R S S R N S L G R A P S L K R R S P S G E R R S L L S G E G Q E S Q D E E E S S E E E R A S P A G S D H R H R G S L E R E A K S S F D L P D T L Q V P G L H R T A S G R G S A S E H Q D C N G K S A S G R L A R A L R P D D P P L D G D D A D D E G N L S K G E R V R A W I R A R L P A C C L E R D S W S A Y I F P P Q S R F R L L C H R I I T H K M F D H V V L V I I F L N C I T I A M E R P K I D P H S A E R I F L T L S N Y I F T A V F L A E M T V K V V A L G W C F G E Q A Y L R S S W N V L D G L L V L I S V I D I L V S M V S D S G T K I L G M L R V L R L L R T L R P L R V I S R A Q G L K L V V E T L M S S L K P I G N I V V I C C A F F I I F G I L G V Q L F K G K F F V C Q G E D T R N I T N K S D C A E A S Y R W V R H K Y N F D N L G Q A L M S L F V L A S K D G W V D I M Y D G L D A V G V D Q Q P I M N H N P W M L L Y F I S F L L I V A F F V L N M F V G V V V E N F H K C R Q H Q E E E E A R R R E E K R L R R L E K K R R N L M L D D V I A S G S S A S A A S E A Q C K P Y Y S D Y S R F R L L V H H L C T S H Y L D L F I T G V I G L N V V T M A M E H Y Q Q P Q I L D E A L K I C N Y I F T V I F V L E S V F K L V A F G F R R F F Q D R W N Q L D L A I V L L S I M G I T L E E I E V N A S L P I N P T I I R I M R V L R I A R V L K L L K M A V G M R A L L D T V M Q A L P Q V G N L G L L F M L L F F I F A A L G V E L F G D L E C D E T H P C E G L G R H A T F R N F G M A F L T L F R V S T G D N W N G I M K D T L R D C D Q E S T C Y N T V I S P I Y F V S F V L T A Q F V L V N V V I A V L M K H L E E S N K E A K E E A E L E A E L E L E M K T L S P Q P H S P L G S P F L W P G V E G P D S P D S P K P G A L H P A A H A R S A S H F S L E H P T D R Q L F D T I S L L I Q G S L E W E L K L M D E L A G P G G Q P S A F P S A P S L G G S D P Q I P L A E M E A L S L T S E I V S E P S C S L A L T D D S L P D D M H T L L L S A L E S N M Q P H P T E L P G P D L L T V R K S G V S R T H S L P N D S Y M C R H G S T A E G P L G H R G W G L P K A Q S G S V L S V H S Q P A D T S Y I L Q L P K D A P H L L Q P H S A P T W G T I P K L P P P G R S P L A Q R P L R R Q A A I R T D S L D V Q G L G S R E D L L A E V S G P S P P L A R A Y S F W G Q S S T Q A Q Q H S R S H S K I S K H M T P P A P C P G P E P N W G K G P P E T R S S L E L D T E L S W I S G D L L P P G G Q E E P P S P R D L K K C Y S V E A Q S C Q R R P T S W L D E Q R R H S I A V S C L D S G S Q P H L G T D P S N L G G Q P L G G P G S R P K K K L S P P S I T I D P P E S Q G P R T P P S P G I C L R R R A P S S D S K D P L A S G P P D S M A A S P S P K K D V L S L S G L S S D P A D L D P
PTM type	X-Methylation X-N-glycosylation X-Phosphorylation X-Ubiquitination X: Amino Acid

Methylation
Arginine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2128
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1G Arginine 2128 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[1]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2128
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1G Arginine 2128 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[1]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2131
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1G Arginine 2131 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[1]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2131
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1G Arginine 2131 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[1]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2132
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1G Arginine 2132 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[1]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	2132
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at CACNA1G Arginine 2132 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1G			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	173
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1G Asparagine 173 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1G			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	246
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1G Asparagine 246 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1G			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	306
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1G Asparagine 306 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1G			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	310
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1G Asparagine 310 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1G			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	322
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1G Asparagine 322 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence CACNA1G			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1448
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1G Asparagine 1448 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence CACNA1G			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1451
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1G Asparagine 1451 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence CACNA1G			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1698
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at CACNA1G Asparagine 1698 has the potential to affect its expression or activity.
Phosphorylation
Serine	21 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1G			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	26
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 26 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1G			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	36
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 36 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1G			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	196
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 196 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1G			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	586
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 586 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1G			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	621
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 621 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	640
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 640 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	646
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 646 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	647
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 647 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence CACNA1G			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	651
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 651 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence CACNA1G			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	659
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 659 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence CACNA1G			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	831
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 831 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence CACNA1G			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1163
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 1163 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence CACNA1G			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1170
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 1170 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence CACNA1G			[3], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1171
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 1171 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence CACNA1G			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2046
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 2046 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2076
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 2076 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2078
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 2078 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2081
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 2081 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2084
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 2084 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2090
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 2090 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence CACNA1G			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2357
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Serine 2357 has the potential to affect its expression or activity.
Threonine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1G			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	151
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Threonine 151 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1G			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	595
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Threonine 595 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1G			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	620
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Threonine 620 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	638
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Threonine 638 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	641
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Threonine 641 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence CACNA1G			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	735
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Threonine 735 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	2089
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Threonine 2089 has the potential to affect its expression or activity.
Tyrosine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1G			[15]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	370
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Tyrosine 370 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence CACNA1G			[15]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	374
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Tyrosine 374 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence CACNA1G			[5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	669
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Tyrosine 669 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence CACNA1G			[7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	2091
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at CACNA1G Tyrosine 2091 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence CACNA1G			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	974
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at CACNA1G Lysine 974 has the potential to affect its expression or activity.

References
1	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: CAC1G_HUMAN)
3	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
4	Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics. 2012 Sep;11(9):651-68.
5	Improved Method for Determining Absolute Phosphorylation Stoichiometry Using Bayesian Statistics and Isobaric Labeling. J Proteome Res. 2017 Nov 3;16(11):4217-4226.
6	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
7	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
8	Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl. J Proteome Res. 2017 Feb 3;16(2):538-549.
9	Phosphotyrosine Biased Enrichment of Tryptic Peptides from Cancer Cells by Combining pY-MIP and TiO2 Affinity Resins. Anal Chem. 2017 Nov 7;89(21):11332-11340.
10	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
11	Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5.
12	Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS. Elife. 2017 Oct 20;6:e27574.
13	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
14	Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer. Anal Chem. 2010 Feb 1;82(3):824-32.
15	An Augmented Multiple-Protease-Based Human Phosphopeptide Atlas. Cell Rep. 2015 Jun 23;11(11):1834-43.
16	Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics. Nat Struct Mol Biol. 2020 Feb;27(2):210-220.

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Detail Information of Post-Translational Modifications

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