| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0525 | ||||
| Gene Name | KCNJ6 | ||||
| Protein Name | Inward rectifier K(+) channel Kir3.2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:3SYA_A Identity:99.696% Minimized Score:-845.977 kcal/mol Detail: Structure Info |
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| Synonyms | BIR1; GIRK-2; GIRK2; G protein-activated inward rectifier potassium channel 2; KATP-2; KATP2; KCNJ6; KCNJ7; KIR3.2; KPLBS; Potassium channel, inwardly rectifying subfamily J member 6; hiGIRK2 | ||||
| DT Family | Inward Rectifier K(+) Channel (IRK-C) Family ; | ||||
| Tissue Specificity | Most abundant in cerebellum, and to a lesserdegree in islets and exocrine pancreas. | ||||
| Function | This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. | ||||
| Endogenous Substrate(s) | Potassium ions | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Inward rectifier K(+) channel Kir3.2 |
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(β) Cell Distribution Level of Inward rectifier K(+) channel Kir3.2 |
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(γ) Organelle Distribution Level of Inward rectifier K(+) channel Kir3.2 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Inward rectifier K(+) channel Kir3.2 |
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(δ) Epigenetic Regulation of Inward rectifier K(+) channel Kir3.2 |
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(ε) Exogenous Modulation of Inward rectifier K(+) channel Kir3.2 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Inward rectifier K(+) channel Kir3.2 |
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(β) Disease-specific Protein Abundances of Inward rectifier K(+) channel Kir3.2 |
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(γ) Species- and Tissue-specific DT Abundances |
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