Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0525 Transporter Info | ||||
| Gene Name | KCNJ6 | ||||
| Protein Name | Inward rectifier K(+) channel Kir3.2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs2835859 | ||||
| Site of GPD | chr21:37645860 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>C | ||||
| Minor Allele Frequency | C=0.0433/194 (Global) | ||||
| Genotype TT | Click to Show/Hide the Full List of Affected Drugs: 3 Drugs in Total | ||||
| Fentanyl | Drug Info | Postoperative Pain | Correlated with the increased drug dose in patients (compare with genotypes CC + CT) | [ 1] | |
| Fentanyl | N.A. | Urinary Retention | Genotype TT is associated with increased dose of fentanyl in people with Pain, Postoperative as compared to genotypes CC + CT. | [ 1] | |
| Fentanyl | N.A. | Pain, Postoperative | Genotype TT is associated with increased dose of fentanyl in people with Pain, Postoperative as compared to genotypes CC + CT. | [ 1] | |
| Genotype CC | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Fentanyl | N.A. | Pain, Postoperative | Patients with the CC genotype and post-operative pain may require a decreased dose of fentanyl as compared to patients with the TT genotypes. Other genetic and clinical factors may also influence dose of fentanyl in people with post-operative pain. | [ 1] | |
| Genotype CT | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Fentanyl | N.A. | Pain, Postoperative | Patients with the CT genotype and post-operative pain may require a decreased dose of fentanyl as compared to patients with the TT genotypes. Other genetic and clinical factors may also influence dose of fentanyl in people with post-operative pain. | [ 1] | |
| Genetic Polymorphism | rs2070995 | ||||
| Site of GPD | chr21:37714662 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>A / T>C | ||||
| Minor Allele Frequency | T=0.1740/344 (Global) | ||||
| Allele C | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Opioids | N.A. | Death | Allele C is not associated with risk of Death due to opioids in people with Opioid-Related Disorders as compared to allele T. | [ 2] | |
| Genotype TT | Click to Show/Hide the Full List of Affected Drugs: 6 Drugs in Total | ||||
| Methadone | N.A. | Death | Genotype TT is associated with increased dose of methadone in people with Substance-Related Disorders as compared to genotypes CC + CT. | [ 3] | |
| Opioids | N.A. | Death | Genotype TT is associated with increased dose of opioids in people with Pain as compared to genotypes CC + CT. | [ 3] | |
| Opioids | N.A. | Death | Genotype TT is associated with increased frequency of rescue analgesic administration when treated with opioids in people with Pain as compared to genotypes CC + CT. | [ 4] | |
| Analgesics | N.A. | Pain | Genotype TT is associated with increased frequency of rescue analgesic administration when treated with opioids in people with Pain as compared to genotypes CC + CT. | [ 4] | |
| Analgesics | N.A. | Pain | Genotype TT is associated with increased dose of methadone in people with Substance-Related Disorders as compared to genotypes CC + CT. | [ 3] | |
| Methadone | N.A. | Heroin Dependence | Genotype TT is associated with decreased risk of withdrawal effects when treated with methadone in people with Heroin Dependence as compared to genotypes CC + CT. | [ 3] | |
| Genotypes CC + CT | Click to Show/Hide the Full List of Affected Drugs: 12 Drugs in Total | ||||
| Morphine | N.A. | Constipation | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Morphine | N.A. | Delirium | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Morphine | N.A. | Nausea | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Morphine | N.A. | Pruritus | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Morphine | N.A. | Somnolence | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Morphine | N.A. | Urinary Retention | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Oxycodone | N.A. | Constipation | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Oxycodone | N.A. | Delirium | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Oxycodone | N.A. | Nausea | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Oxycodone | N.A. | Pruritus | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Oxycodone | N.A. | Somnolence | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Oxycodone | N.A. | Urinary Retention | Genotypes CC + CT are not associated with likelihood of Constipation, Delirium, Nausea, Pruritus, somnolence or Urinary Retention due to morphine or oxycodone in people with Lung Neoplasms as compared to genotype TT. | [ 5] | |
| Genotype CC | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Analgesics | N.A. | Pain | Patients with the CC genotype and post-operative pain may be less likely to require rescue analgesic administration as compared to patients with the TT genotype. Additionally, patients with the CC genotype who are addicted to heroin may require a decreased dose of methadone as compared to patients with the TT genotype. Other genetic and clinical factors may also influence a patient's chance for requiring a rescue analgesic and dose of methadone. | [ 4] | |
| Methadone | N.A. | Heroin Dependence | Patients with the CC genotype who are addicted to heroin may have increased withdrawal symptoms when treated with methadone as compared to patients with the TT genotype. Other genetic and clinical factors may also influence withdrawal symptoms in patients treated with methadone. | [ 3] | |
| Genotype CT | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Analgesics | N.A. | Pain | Patients with the CT genotype and post-operative pain may be less likely to require rescue analgesic administration as compared to patients with the TT genotype. Additionally, patients with the CT genotype who are addicted to heroin may require a decreased dose of methadone as compared to patients with the TT genotype. Other genetic and clinical factors may also influence a patient's chance for requiring a rescue analgesic and dose of methadone. | [ 4] | |
| Methadone | N.A. | Heroin Dependence | Patients with the CT genotype who are addicted to heroin may have increased withdrawal symptoms when treated with methadone as compared to patients with the TT genotype. Other genetic and clinical factors may also influence withdrawal symptoms in patients treated with methadone. | [ 3] | |
| Genetic Polymorphism | rs6517442 | ||||
| Site of GPD | chr21:37917643 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | C>G / C>T | ||||
| Minor Allele Frequency | C=0.1960/387 (Global) | ||||
| Genotype CC | Click to Show/Hide the Full List of Affected Drugs: 4 Drugs in Total | ||||
| Opioids | N.A. | Death | Genotype CC is associated with increased dose of opioids in people with Low Back Pain as compared to genotypes CT + TT. | [ 6] | |
| Morphine | N.A. | Death | Genotype CC is associated with increased response to morphine in infants with Pain as compared to genotypes CT + TT. | [ 7] | |
| Opioids | N.A. | Low Back Pain | Genotype CC is associated with increased dose of opioids in people with Low Back Pain as compared to genotypes CT + TT. | [ 6] | |
| Morphine | N.A. | Pain | Genotype CC is associated with increased response to morphine in infants with Pain as compared to genotypes CT + TT. | [ 7] | |
| Allele C | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Remifentanil | N.A. | Death | Allele C is not associated with response to remifentanil in infants with Pain as compared to allele T. | [ 7] | |
| Genotype TT | Click to Show/Hide the Full List of Affected Drugs: 4 Drugs in Total | ||||
| Morphine | N.A. | Death | Genotype TT is associated with decreased response to morphine or remifentanil in infants with Pain as compared to genotypes CC + CT. | [ 7] | |
| Remifentanil | N.A. | Death | Genotype TT is associated with decreased response to morphine or remifentanil in infants with Pain as compared to genotypes CC + CT. | [ 7] | |
| Opioids | N.A. | Low Back Pain | Patients with the rs6517442 TT genotype may have decreased opioid dose requirements as compared to patients with the CC genotype. Other genetic and clinical factors may also affect opioid dose requirements. | [ 6] | |
| Morphine | N.A. | Pain | Genotype TT is associated with decreased response to morphine or remifentanil in infants with Pain as compared to genotypes CC + CT. | [ 7] | |
| Genotype CT | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Opioids | N.A. | Low Back Pain | Patients with the rs6517442 CT genotype may have decreased opioid dose requirements as compared to patients with the CC genotype. Other genetic and clinical factors may also affect opioid dose requirements. | [ 6] | |
| Morphine | N.A. | Pain | Patients with the CT genotype may have an increased analgesic response to morphine as compared to patients with the TT genotype, but a decreased response as compared to patients with the CC genotype. Other genetic or clinical factors may also affect a patient's response to morphine. | [ 7] | |
| References | |||||
| 1 | Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. PLoS One. 2015 Jan 23;10(1):e0116885. | ||||
| 2 | The ABCB1, rs9282564, AG and TT Genotypes and the COMT, rs4680, AA Genotype are Less Frequent in Deceased Patients with Opioid Addiction than in Living Patients with Opioid Addiction. Basic Clin Pharmacol Toxicol. 2016 Oct;119(4):381-8. | ||||
| 3 | A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size. Pharmacogenet Genomics. 2010 May;20(5):291-7. | ||||
| 4 | Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery. PLoS One. 2009 Sep 16;4(9):e7060. | ||||
| 5 | Influence of genetic variants of opioid-related genes on opioid-induced adverse effects in patients with lung cancer: A STROBE-compliant observational study. Medicine (Baltimore). 2021 Nov 05;100(44):e27565. | ||||
| 6 | Genetic Contribution in Low Back Pain: A Prospective Genetic Association Study. Pain Pract. 2019 Nov;19(8):836-847. | ||||
| 7 | Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation. Ther Drug Monit. 2016 Aug;38(4):525-33. | ||||
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