Drug Transporter (DT) Information

General Information of DT
DT ID DTD0523
Gene Name CACNG2
Protein Name Voltage-dependent calcium channel gamma-2
Gene ID
10369
UniProt ID
Q9Y698
TCDB ID
8.A.16.2.1
3D Structure

Crystal Structure

Crystallisation Method:EM

PDB ID:6DLZ

Corresponding Chain:A/B/C/D

Sequence Length:2-208

Detail: Struture Info

Synonyms CACNG2; MRD10; Neuronal voltage-gated calcium channel gamma-2 subunit; TARP gamma-2; Transmembrane AMPAR regulatory protein gamma-2; Voltage-dependent calcium channel gamma-2 subunit
DT Family Ca(+) Channel Auxiliary Subunit Gama1-Gama8 (CCAgama) Family ;
Tissue Specificity Expressed in brain.
Function This transporter regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Endogenous Substrate(s) Ca2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Voltage-dependent calcium channel gamma-2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Voltage-dependent calcium channel gamma-2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Voltage-dependent calcium channel gamma-2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Voltage-dependent calcium channel gamma-2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Voltage-dependent calcium channel gamma-2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Voltage-dependent calcium channel gamma-2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Voltage-dependent calcium channel gamma-2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Voltage-dependent calcium channel gamma-2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Voltage-dependent calcium channel gamma-2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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