General Information of Drug Transporter (DT)
DT ID	DTD0523 Transporter Info
Gene Name	CACNG2
Protein Name	Voltage-dependent calcium channel gamma-2
Gene ID	10369
UniProt ID	Q9Y698
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs2284018
Site of GPD	chr22:36701519 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>G / C>T
Minor Allele Frequency	T=0.2338/901 (Global)
Genotype TT	Click to Show/Hide the Full List of Affected Drugs:           3 Drugs in Total
Lithium	N.A.	Pain, Postoperative	Genotype TT is associated with decreased response to lithium in people with Bipolar Disorder as compared to genotypes CC + CT.		[ 1]
Lithium	N.A.	Bipolar Disorder	Genotype TT is associated with decreased response to lithium in people with Bipolar Disorder as compared to genotypes CC + CT.		[ 1]
Lithium	N.A.	Bipolar Disorder	Correlated with the decreased drug response in patients (compare with genotypes CC + CT)		[ 1]
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Lithium	N.A.	Bipolar Disorder	Patients with the CC genotype and Bipolar Disorder may be more likely to respond to lithium as compared to patients with the TT genotype. Other genetic and clinical factors may also influence a patient's response to lithium.		[ 1]
Genotype CT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Lithium	N.A.	Bipolar Disorder	Patients with the CT genotype and Bipolar Disorder may be more likely to respond to lithium as compared to patients with the TT genotype. Other genetic and clinical factors may also influence a patient's response to lithium.		[ 1]
Genetic Polymorphism	rs2284017
Site of GPD	chr22:36700882 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>C / T>G
Minor Allele Frequency	T=0.5790/1145 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Lithium	N.A.	Pain, Postoperative	Allele C is associated with increased response to lithium in people with Bipolar Disorder as compared to allele T.		[ 1]
Lithium	N.A.	Bipolar Disorder	Allele C is associated with increased response to lithium in people with Bipolar Disorder as compared to allele T.		[ 1]
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Lithium	N.A.	Pain, Postoperative	Genotype CC is associated with increased response to lithium in people with Bipolar Disorder.		[ 2]
Lithium	N.A.	Bipolar Disorder	Genotype CC is associated with increased response to lithium in people with Bipolar Disorder.		[ 2]
Genotype CT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Lithium	N.A.	Bipolar Disorder	Patients with the CT genotype may have increased response to lithium as compared to patients with the TT genotype. Other genetic and clinical factors may also influence a patient's response to treatment.		[ 2]
Genotype TT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Lithium	N.A.	Bipolar Disorder	Patients with the TT genotype may have decreased response to lithium as compared to patients with the CC genotype. Other genetic and clinical factors may also influence a patient's response to treatment.		[ 2]
References
1	Stargazin involvement with bipolar disorder and response to lithium treatment. Pharmacogenet Genomics. 2008 May;18(5):403-12.
2	Pharmacogenetics of lithium response in bipolar disorder. Pharmacogenomics. 2010 Oct;11(10):1439-65.

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