Crystal Structure
Crystallisation Method:EM
Corresponding Chain:A
Sequence Length:1-1220
Detail: Struture Info
Drug Transporter (DT) Information
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| General Information of DT | |||||
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| DT ID | DTD0516 | ||||
| Gene Name | ATP2B1 | ||||
| Protein Name | Plasma membrane calcium-transporting ATPase 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Crystal Structure Crystallisation Method:EM Corresponding Chain:A Sequence Length:1-1220 Detail: Struture Info |
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| Synonyms | ATP2B1; PMCA1; PMCA1kb; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1 | ||||
| DT Family | P-Type ATPase (P-ATPase) Superfamily ; | ||||
| Tissue Specificity | Isoform B: Ubiquitously expressed. Isoform C:Found in brain cortex, skeletal muscle and heart muscle. IsoformD: Has only been found in fetal skeletal muscle. Isoform K: Foundin small intestine and liver. | ||||
| Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. | ||||
| Endogenous Substrate(s) | Ca2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Plasma membrane calcium-transporting ATPase 1 |
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(β) Cell Distribution Level of Plasma membrane calcium-transporting ATPase 1 |
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(γ) Organelle Distribution Level of Plasma membrane calcium-transporting ATPase 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Plasma membrane calcium-transporting ATPase 1 |
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(γ) Transcriptional Regulation of Plasma membrane calcium-transporting ATPase 1 |
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(δ) Epigenetic Regulation of Plasma membrane calcium-transporting ATPase 1 |
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(ε) Exogenous Modulation of Plasma membrane calcium-transporting ATPase 1 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Plasma membrane calcium-transporting ATPase 1 |
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(β) Disease-specific Protein Abundances of Plasma membrane calcium-transporting ATPase 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.