Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0516 Transporter Info
Gene Name	ATP2B1
Transporter Name	Plasma membrane calcium-transporting ATPase 1
Gene ID	490
UniProt ID	P20020

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Blood; Bone marrow; Colon; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[4]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[1]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 2 (FOSL2) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[2]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[4]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ATP2B1 gene in embryonic stem cells condition			[5]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of ATP2B1 gene in embryonic stem cells condition, which leads to an affected expression of the drug transporter Plasma membrane calcium-transporting ATPase 1.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[3]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Embryo; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[4]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[3]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ATP2B1 gene in prostate cancer condition			[6]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of ATP2B1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Transcriptional Phenomenon2	Activation of ATP2B1 gene in castration-resistant prostate cancers condition			[7]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Androgen receptor (AR) has been reported to activate the transcription of ATP2B1 gene in castration-resistant prostate cancers condition, which leads to an increased expression of the drug transporter Plasma membrane calcium-transporting ATPase 1.
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[4]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Estrogen receptor (ESR1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ATP2B1 gene in health condition			[8]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of ATP2B1 gene in health condition, which leads to an affected expression of the drug transporter Plasma membrane calcium-transporting ATPase 1.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[4]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast; Epithelium; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[1]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
GATA3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[2]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Tissue	Blood; Brain; Breast; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
GATA4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ATP2B1 gene in gastric cancer condition			[9]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of ATP2B1 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[3]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
GLIS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[2]
TF Protein Name	Zinc finger protein GLIS1		Transcription Factor Info
Tissue	Blood; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein GLIS1 (GLIS1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[3]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[3]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[4]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[1]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Tissue	Blood; Colon; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp1 (SP1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
VEZF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[1]
TF Protein Name	Vascular endothelial zinc finger 1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Vascular endothelial zinc finger 1 (VEZF1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[2]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NKX2-1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[1]
TF Protein Name	Homeobox protein Nkx-2.1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein Nkx-2.1 (NKX2-1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[2]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ATP2B1 gene in health condition			[10]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of ATP2B1 gene in health condition, which leads to an affected expression of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Transcriptional Phenomenon2	Direct binding to ATP2B1 gene			[2]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ATP2B1 gene in health condition			[8]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of ATP2B1 gene in health condition, which leads to an affected expression of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Transcriptional Phenomenon2	Direct binding to ATP2B1 gene			[2]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[3]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[4]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[4]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[3]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ATP2B1 gene in colorectal cancer condition			[11]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of ATP2B1 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Plasma membrane calcium-transporting ATPase 1.
TF Superclass6: Immunoglobulin fold
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ATP2B1 gene in health condition			[12]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of ATP2B1 gene in health condition, which leads to an affected expression of the drug transporter Plasma membrane calcium-transporting ATPase 1.
RUNX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[4]
TF Protein Name	Runt-related transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 3 (RUNX3) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[3]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[1]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ATP2B1 gene in epithelial ovarian cancer condition			[13]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of ATP2B1 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Plasma membrane calcium-transporting ATPase 1.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[1]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.
SETDB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ATP2B1 gene			[2]
TF Protein Name	Histone-lysine N-methyltransferase SETDB1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Histone-lysine N-methyltransferase SETDB1 (SETDB1) can directly bind to the ATP2B1 gene, which in turn affects the expression or function of the drug transporter Plasma membrane calcium-transporting ATPase 1.

References
1	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
2	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-158. (ID:ENSG00000070961)
4	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5	Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
6	Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
7	Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer. Oncogene. 2012;31(17):2153-63.
8	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
9	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
10	Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome. J Biol Chem. 2011;286(14):11985-96.
11	ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
12	Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 2007;21(15):1882-94.
13	ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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Detail Information of Transcriptional Regulations

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