General Information of Drug Transporter (DT)
DT ID DTD0516 Transporter Info
Gene Name ATP2B1
Transporter Name Plasma membrane calcium-transporting ATPase 1
Gene ID
490
UniProt ID
P20020
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

Testosterone co-treated with Calcitriol results in increased expression of ATP2B1 mRNA [6]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Testosterone co-treated with Calcitriol results in increased expression of ATP2B1 mRNA [6]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Cyclosporine results in increased expression of ATP2B1 mRNA [42]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Cisplatin co-treated with jinfukang results in decreased expression of ATP2B1 mRNA [9]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Cisplatin results in increased expression of ATP2B1 mRNA [41]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

EGF protein inhibits the reaction Estradiol results in decreased expression of ATP2B1 mRNA [13]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate results in decreased expression of ATP2B1 mRNA [5]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Valproic Acid affects the expression of ATP2B1 mRNA [57]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of ATP2B1 mRNA [17]

Regulation Mechanism

Transcription Factor Info

  1-Methyl-4-phenylpyridinium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

1-Methyl-4-phenylpyridinium results in decreased expression of ATP2B1 mRNA [23]

Regulation Mechanism

Transcription Factor Info

  2,2',4,4'-tetrabromodiphenyl ether

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ATP2B1 protein [26]

Regulation Mechanism

Transcription Factor Info

  2,3-bis(3'-hydroxybenzyl)butyrolactone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of ATP2B1 mRNA [17]

Regulation Mechanism

Transcription Factor Info

  2,3-dimethoxy-1,4-naphthoquinone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ATP2B1 mRNA [12]

Regulation Mechanism

Transcription Factor Info

  2,4,6-tribromophenol

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

2,4,6-tribromophenol results in increased expression of ATP2B1 mRNA [26]

Regulation Mechanism

Transcription Factor Info

  2-palmitoylglycerol

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

2-palmitoylglycerol results in increased expression of ATP2B1 mRNA [32]

Regulation Mechanism

Transcription Factor Info

  3,4,5,3',4'-pentachlorobiphenyl

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

3,4,5,3',4'-pentachlorobiphenyl co-treated with Cholecalciferol results in decreased expression of ATP2B1 mRNA [33]

Regulation Mechanism

Transcription Factor Info

  7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATP2B1 mRNA [34]

Regulation Mechanism

Transcription Factor Info

  Am 580

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Am 580 results in decreased expression of ATP2B1 mRNA [2]

Regulation Mechanism

Transcription Factor Info

  Antimony Potassium Tartrate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Antimony Potassium Tartrate results in decreased expression of ATP2B1 mRNA [12]

Regulation Mechanism

Transcription Factor Info

  aristolochic acid I

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

aristolochic acid I results in decreased expression of ATP2B1 mRNA [35]

Regulation Mechanism

Transcription Factor Info

  Asbestos, Crocidolite

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Asbestos, Crocidolite results in decreased expression of ATP2B1 mRNA [36]

Regulation Mechanism

Transcription Factor Info

  Asbestos, Serpentine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Asbestos, Serpentine results in increased expression of ATP2B1 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  beta-lapachone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

beta-lapachone results in decreased expression of ATP2B1 mRNA [38]

Regulation Mechanism

Transcription Factor Info

  bisphenol A

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

bisphenol A results in decreased expression of ATP2B1 protein [26]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

bisphenol A results in increased expression of ATP2B1 protein [29]

Regulation Mechanism

Transcription Factor Info

  bisphenol B

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

bisphenol B results in increased expression of ATP2B1 protein [29]

Regulation Mechanism

Transcription Factor Info

  bisphenol F

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

bisphenol F results in increased expression of ATP2B1 protein [29]

Regulation Mechanism

Transcription Factor Info

  Bucladesine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate results in decreased expression of ATP2B1 mRNA [5]

Regulation Mechanism

Transcription Factor Info

  Cadmium Chloride

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cadmium Chloride results in decreased expression of ATP2B1 mRNA [12]

Regulation Mechanism

Transcription Factor Info

  caloxin 1b1

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

caloxin 1b1 inhibits the reaction ATP2B1 protein results in increased export of Calcium [40]

Regulation Mechanism

Transcription Factor Info

  Cholecalciferol

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

3,4,5,3',4'-pentachlorobiphenyl co-treated with Cholecalciferol results in decreased expression of ATP2B1 mRNA [33]

Regulation Mechanism

Transcription Factor Info

  coumarin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

coumarin results in decreased phosphorylation of ATP2B1 protein [39]

Regulation Mechanism

Transcription Factor Info

  decabromobiphenyl ether

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

decabromobiphenyl ether results in decreased expression of ATP2B1 protein [26]

Regulation Mechanism

Transcription Factor Info

  Dimethylnitrosamine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Dimethylnitrosamine results in decreased expression of ATP2B1 mRNA [12]

Regulation Mechanism

Transcription Factor Info

  di-n-butylphosphoric acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

di-n-butylphosphoric acid affects the expression of ATP2B1 mRNA [43]

Regulation Mechanism

Transcription Factor Info

  epigallocatechin gallate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of ATP2B1 mRNA [44]

Regulation Mechanism

Transcription Factor Info

  FR900359

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

FR900359 affects the phosphorylation of ATP2B1 protein [45]

Regulation Mechanism

Transcription Factor Info

  Isoflavones

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Isoflavones results in increased expression of ATP2B1 mRNA [46]

Regulation Mechanism

Transcription Factor Info

  K 7174

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

K 7174 results in increased expression of ATP2B1 mRNA [22]

Regulation Mechanism

Transcription Factor Info

  Medroxyprogesterone Acetate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate results in decreased expression of ATP2B1 mRNA [5]

Regulation Mechanism

Transcription Factor Info

  methylmercuric chloride

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

methylmercuric chloride results in decreased expression of ATP2B1 mRNA [47]

Regulation Mechanism

Transcription Factor Info

  Methyl Methanesulfonate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Methyl Methanesulfonate results in decreased expression of ATP2B1 mRNA [48]

Regulation Mechanism

Transcription Factor Info

  Okadaic Acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Okadaic Acid results in increased expression of ATP2B1 mRNA [49]

Regulation Mechanism

Transcription Factor Info

  Ozone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Air Pollutants results in increased abundance of Ozone which affects the expression of ATP2B1 mRNA [50]

Regulation Mechanism

Transcription Factor Info

  potassium chromate(VI)

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of ATP2B1 mRNA [44]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

potassium chromate(VI) results in decreased expression of ATP2B1 mRNA [44]

Regulation Mechanism

Transcription Factor Info

  Potassium Dichromate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Potassium Dichromate results in decreased expression of ATP2B1 mRNA [12]

Regulation Mechanism

Transcription Factor Info

  S-(1,2-dichlorovinyl)cysteine

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides which results in increased expression of ATP2B1 mRNA [53]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides results in increased expression of ATP2B1 mRNA [53]

Regulation Mechanism

Transcription Factor Info

  sodium arsenite

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

sodium arsenite affects the expression of ATP2B1 mRNA [28]

Regulation Mechanism

Transcription Factor Info

  tamibarotene

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

tamibarotene affects the expression of ATP2B1 mRNA [1]

Regulation Mechanism

Transcription Factor Info

  tert-Butylhydroperoxide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

tert-Butylhydroperoxide results in increased expression of ATP2B1 mRNA [54]

Regulation Mechanism

Transcription Factor Info

  testosterone enanthate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

testosterone enanthate affects the expression of ATP2B1 mRNA [3]

Regulation Mechanism

Transcription Factor Info

  tetrabromobisphenol A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

tetrabromobisphenol A results in decreased expression of ATP2B1 protein [26]

Regulation Mechanism

Transcription Factor Info

  Tetrachlorodibenzodioxin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tetrachlorodibenzodioxin results in decreased expression of ATP2B1 mRNA [42]

Regulation Mechanism

Transcription Factor Info

  tetrahydropalmatine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

tetrahydropalmatine results in decreased expression of ATP2B1 protein [19]

Regulation Mechanism

Transcription Factor Info

  Thiram

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Thiram results in increased expression of ATP2B1 mRNA [55]

Regulation Mechanism

Transcription Factor Info

  trichostatin A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

trichostatin A results in decreased expression of ATP2B1 mRNA [24]

Regulation Mechanism

Transcription Factor Info

  tris(2-butoxyethyl) phosphate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

tris(2-butoxyethyl) phosphate affects the expression of ATP2B1 mRNA [56]

Regulation Mechanism

Transcription Factor Info

  Vanadium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Vanadium results in increased expression of ATP2B1 mRNA [16]

Regulation Mechanism

Transcription Factor Info

Dietary Constituent

  Calcium

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

ATP2B1 protein results in increased export of Calcium [40]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

caloxin 1b1 inhibits the reaction ATP2B1 protein results in increased export of Calcium [40]

Regulation Mechanism

Transcription Factor Info

Nanoparticle

  perfluoro-n-nonanoic acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

perfluoro-n-nonanoic acid results in increased expression of ATP2B1 mRNA [51]

Regulation Mechanism

Transcription Factor Info

Approved Drug

  Tretinoin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tretinoin inhibits the expression of ATP2B1 [1]

  Rosiglitazone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Rosiglitazone inhibits the expression of ATP2B1 [2]

  Testosterone enanthate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Testosterone enanthate affects the expression of ATP2B1 [3]

  Phenobarbital

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Phenobarbital affects the expression of ATP2B1 [4]

  Azacitidine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Azacitidine inhibits the expression of ATP2B1 [5]

  Calcitriol

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Calcitriol increases the expression of ATP2B1 [6]

  Testosterone

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Testosterone increases the expression of ATP2B1 [6]

  Melphalan

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Melphalan inhibits the expression of ATP2B1 [7]

  Cyclosporine

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cyclosporine inhibits the expression of ATP2B1 [8]

  Cisplatin

           3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cisplatin inhibits the expression of ATP2B1 [9]

  Sunitinib

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Sunitinib increases the expression of ATP2B1 [10]

  Ivermectin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Ivermectin inhibits the expression of ATP2B1 [11]

  Arsenic Trioxide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Arsenic Trioxide inhibits the expression of ATP2B1 [12]

  Estradiol

           3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Estradiol inhibits the expression of ATP2B1 [13]

  Acetaminophen

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acetaminophen increases the expression of ATP2B1 [14]

  Valproic Acid

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Valproic Acid increases the expression of ATP2B1 [15]

Drug in Phase 2/3 Trial

  AM-80

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

AM-80 affects the expression of ATP2B1 [1]

Drug in Phase 2 Trial

  Antimony

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Antimony inhibits the expression of ATP2B1 [12]

  Tetrahydropalmatine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tetrahydropalmatine inhibits the expression of ATP2B1 [19]

  Bisphenol A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Bisphenol A inhibits the expression of ATP2B1 [26]

  Bisphenol B

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Bisphenol B increases the expression of ATP2B1 [29]

Drug in Phase 1 Trial

  Trichostatin A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Trichostatin A inhibits the expression of ATP2B1 [24]

  Sodium arsenite

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Sodium arsenite affects the expression of ATP2B1 [28]

Investigative Drug

  Coumestrol

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Coumestrol inhibits the expression of ATP2B1 [17]

Patented Pharmaceutical Agent

  AM-580

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

AM-580 inhibits the expression of ATP2B1 [2]

  K-7174

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

K-7174 increases the expression of ATP2B1 [22]

  GSK-J4

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

GSK-J4 increases the expression of ATP2B1 [25]

Natural Product

  Coal Ash

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Coal Ash inhibits the expression of ATP2B1 [16]

  Tobacco Smoke Pollution

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tobacco Smoke Pollution increases the expression of ATP2B1 [27]

  Gallic Acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Gallic Acid increases the expression of ATP2B1 [30]

  Caffeine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Caffeine results in decreased phosphorylation of ATP2B1 protein [39]

Regulation Mechanism

Transcription Factor Info

  Resveratrol

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Plant Extracts co-treated with Resveratrol results in increased expression of ATP2B1 mRNA [52]

Regulation Mechanism

Transcription Factor Info

Traditional Medicine

  Jinfukang

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Jinfukang inhibits the expression of ATP2B1 [9]

Plant Extract

  Plant Extracts

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Plant Extracts increases the expression of ATP2B1 [20]

Environmental toxicant

  Antimony potassium tartrate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Antimony potassium tartrate inhibits the expression of ATP2B1 [12]

  Zinc Oxide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Zinc Oxide inhibits the expression of ATP2B1 [21]

  Tetrabromobisphenol A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tetrabromobisphenol A inhibits the expression of ATP2B1 [26]

  Bisphenol F

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Bisphenol F increases the expression of ATP2B1 [29]

  Polychlorinated dibenzodioxin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Polychlorinated dibenzodioxin inhibits the expression of ATP2B1 [31]

Acute Toxic Substance

  Cadmium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cadmium inhibits the expression of ATP2B1 [12]

Carcinogen

  Dimethyl nitrosamine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Dimethyl nitrosamine inhibits the expression of ATP2B1 [12]

  Benzo(a)pyrene

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Benzo(a)pyrene inhibits the expression of ATP2B1 [18]

  Chromium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Chromium results in decreased expression of ATP2B1 mRNA [12]

Regulation Mechanism

Transcription Factor Info

Health and Environmental Toxicant

  1-methyl-4-phenylpyridinium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

1-methyl-4-phenylpyridinium inhibits the expression of ATP2B1 [23]
References
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2 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
3 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802.
4 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75.
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6 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
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11 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975.
12 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
13 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
14 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
15 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
16 Endothelial effects of emission source particles: acute toxic response gene expression profiles. Toxicol In Vitro. 2009 Feb;23(1):67-77.
17 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
18 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
19 Shotgun approach based comparative proteomic analysis of levo-tetrahydropalmatine-induced apoptosis in hepatocytes. Toxicol Lett. 2010 Apr 15;194(1-2):8-15.
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