Drug Transporter (DT) Information

General Information of DT
DT ID DTD0497
Gene Name SLC9C1
Protein Name Sodium/hydrogen exchanger 10
Gene ID
285335
UniProt ID
Q4G0N8
TCDB ID
2.A.36.7.5
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms NHE; NHE-10; Na(+)/H(+) exchanger 10; SLC9A10; SLC9C1; Solute carrier family 9 member 10; Solute carrier family 9 member C1; Sperm-specific Na(+)/H(+) exchanger; sNHE; sperm-NHE
DT Family Monovalent Cation:Proton Antiporter-1 (CPA1) family ;
Function This transporter is involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Sperm-specific sodium/hydrogen exchanger gets involved in intracellular pH regulation of spermatozoa and Required for sperm motility and fertility. So the transporter is required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC).
Endogenous Substrate(s) Na+; H+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/hydrogen exchanger 10
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/hydrogen exchanger 10
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/hydrogen exchanger 10
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium/hydrogen exchanger 10
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium/hydrogen exchanger 10
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/hydrogen exchanger 10
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/hydrogen exchanger 10
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/hydrogen exchanger 10
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/hydrogen exchanger 10
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.