Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0497 Transporter Info
Gene Name	SLC9C1
Transporter Name	Sodium/hydrogen exchanger 10
Gene ID	285335
UniProt ID	Q4G0N8

Post-Translational Modification of This DT
Overview ofSLC9C1 Modification Sites with Functional and Structural Information
Sequence	M A G I F K E F F F S T E D L P E V I L T L S L I S S I G A F L N R H L E D F P I P V P V I L F L L G C S F E V L S F T S S Q V Q R Y A N A I Q W M S P D L F F R I F T P V V F F T T A F D M D T Y M L Q K L F W Q I L L I S I P G F L V N Y I L V L W H L A S V N Q L L L K P T Q W L L F S A I L V S S D P M L T A A A I R D L G L S R S L I S L I N G E S L M T S V I S L I T F T S I M D F D Q R L Q S K R N H T L A E E I V G G I C S Y I I A S F L F G I L S S K L I Q F W M S T V F G D D V N H I S L I F S I L Y L I F Y I C E L V G M S G I F T L A I V G L L L N S T S F K A A I E E T L L L E F W T F L S R I A F L M V F T F F G L L I P A H T Y L Y I E F V D I Y Y S L N I Y L T L I V L R F L T L L L I S P V L S R V G H E F S W R W I F I M V C S E M K G M P N I N M A L L L A Y S D L Y F G S D K E K S Q I L F H G V L V C L I T L V V N R F I L P V A V T I L G L R D A T S T K Y K S V C C T F Q H F Q E L T K S A A S A L K F D K D L A N A D W N M I E K A I T L E N P Y M L N E E E T T E H Q K V K C P H C N K E I D E I F N T E A M E L A N R R L L S A Q I A S Y Q R Q Y R N E I L S Q S A V Q V L V G A A E S F G E K K G K C M S L D T I K N Y S E S Q K T V T F A R K L L L N W V Y N T R K E K E G P S K Y F F F R I C H T I V F T E E F E H V G Y L V I L M N I F P F I I S W I S Q L N V I Y H S E L K H T N Y C F L T L Y I L E A L L K I A A M R K D F F S H A W N I F E L A I T L I G I L H V I L I E I D T I K Y I F N E T E V I V F I K V V Q F F R I L R I F K L I A P K L L Q I I D K R M S H Q K T F W Y G I L K G Y V Q G E A D I M T I I D Q I T S S K Q I K Q M L L K Q V I R N M E H A I K E L G Y L E Y D H P E I A V T V K T K E E I N V M L N M A T E I L K A F G L K G I I S K T E G A G I N K L I M A K K K E V L D S Q S I I R P L T V E E V L Y H I P W L D K N K D Y I N F I Q E K A K V V T F D C G N D I F E E G D E P K G I Y I I I S G M V K L E K S K P G L G I D Q M V E S K E K D F P I I D T D Y M L S G E I I G E I N C L T N E P M K Y S A T C K T V V E T C F I P K T H L Y D A F E Q C S P L I K Q K M W L K L G L A I T A R K I R E H L S Y E D W N Y N M Q L K L S N I Y V V D I P M S T K T D I Y D E N L I Y V I L I H G A V E D C L L R K T Y R A P F L I P I T C H Q I Q S I E D F T K V V I I Q T P I N M K T F R R N I R K F V P K H K S Y L T P G L I G S V G T L E E G I Q E E R N V K E D G A H S A A T A R S P Q P C S L L G T K F N C K E S P R I N L R K V R K E
PTM type	X-N-glycosylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9C1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	278
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC9C1 Asparagine 278 has the potential to affect its expression or activity.
Phosphorylation
Serine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9C1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	349
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9C1 Serine 349 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9C1			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	526
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9C1 Serine 526 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC9C1			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	537
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9C1 Serine 537 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC9C1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	832
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9C1 Serine 832 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC9C1			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	853
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9C1 Serine 853 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC9C1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	855
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9C1 Serine 855 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9C1			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	861
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9C1 Threonine 861 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9C1			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1159
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9C1 Threonine 1159 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9C1			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	531
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9C1 Tyrosine 531 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9C1			[7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	878
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9C1 Tyrosine 878 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: SL9C1_HUMAN)
2	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
3	Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen. Mol Cell Proteomics. 2016 Mar;15(3):1032-47.
4	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
5	Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib. J Proteomics. 2018 Jan 6;170:130-140.
6	Improve the coverage for the analysis of phosphoproteome of HeLa cells by a tandem digestion approach. J Proteome Res. 2012 May 4;11(5):2828-37.
7	Tip-Based Fractionation of Batch-Enriched Phosphopeptides Facilitates Easy and Robust Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):46-54.

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Detail Information of Post-Translational Modifications

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