| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0493 | ||||
| Gene Name | SLC9A8 | ||||
| Protein Name | Sodium/hydrogen exchanger 8 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:1Y4E_A; 2MDF_A Identity:54.545%;60.417% Minimized Score:-125.711 kcal/mol Detail: Structure Info |
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| Synonyms | KIAA0939; NHE-8; NHE8; Na(+)/H(+) exchanger 8; SLC9A8; Solute carrier family 9 member 8 | ||||
| DT Family | Monovalent Cation:Proton Antiporter-1 (CPA1) family ; | ||||
| Tissue Specificity | Ubiquitous. Strongly expressed in skeletalmuscle and kidney. | ||||
| Function | This transporter mediates and participates in regulating pH value to eliminate acids generated by active metabolism or to combat adverse environmental conditions. | ||||
| Endogenous Substrate(s) | Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium/hydrogen exchanger 8 |
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(β) Cell Distribution Level of Sodium/hydrogen exchanger 8 |
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(γ) Organelle Distribution Level of Sodium/hydrogen exchanger 8 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium/hydrogen exchanger 8 |
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(γ) Transcriptional Regulation of Sodium/hydrogen exchanger 8 |
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(δ) Epigenetic Regulation of Sodium/hydrogen exchanger 8 |
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(ε) Exogenous Modulation of Sodium/hydrogen exchanger 8 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium/hydrogen exchanger 8 |
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(β) Disease-specific Protein Abundances of Sodium/hydrogen exchanger 8 |
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(γ) Species- and Tissue-specific DT Abundances |
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