Drug Transporter (DT) Information

General Information of DT
DT ID DTD0443
Gene Name SLC6A11
Protein Name Sodium- and chloride-dependent GABA transporter 3
Gene ID
6538
UniProt ID
P48066
TCDB ID
2.A.22.3.9
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4XPT_A

Identity:46.715%

Minimized Score:-1497.544 kcal/mol

Detail: Structure Info

Synonyms GABT3; GAT-3; GAT3; GAT4; SLC6A11; Solute carrier family 6 member 11
DT Family Neurotransmitter:Sodium Symporter (NSS) Family ;
Tissue Specificity Widespread distribution in the brain.
Function This transporter terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Endogenous Substrate(s) Cl-; Gamma-butyric acid; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium- and chloride-dependent GABA transporter 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium- and chloride-dependent GABA transporter 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium- and chloride-dependent GABA transporter 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium- and chloride-dependent GABA transporter 3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium- and chloride-dependent GABA transporter 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium- and chloride-dependent GABA transporter 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium- and chloride-dependent GABA transporter 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium- and chloride-dependent GABA transporter 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium- and chloride-dependent GABA transporter 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Beta-alanine
 Phase 4 Drug Info Muscle function VC01 [1]
References
1 Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7.

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