Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0443 Transporter Info
Gene Name SLC6A11
Transporter Name Sodium- and chloride-dependent GABA transporter 3
Gene ID
6538
UniProt ID
P48066

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NFIL3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A11 gene in epileptic seizures condition [1]

TF Protein Name

 Nuclear factor interleukin-3-regulated protein Transcription Factor Info

Studied Phenotype

 Epileptic seizures [ICD11: 8A60-8A6Z]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 Rev-erba KO mice

Detailed Description

 Nuclear factor interleukin-3-regulated protein (NFIL3) has been reported to activate the transcription of SLC6A11 gene in epileptic seizures condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A11 gene in prostate cancer condition [2]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC6A11 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A11 gene in health condition [3]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC6A11 gene in health condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.

        NR1D1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A11 gene in epileptic seizures condition [1]

TF Protein Name

 Nuclear receptor subfamily 1 group D member 1 Transcription Factor Info

Studied Phenotype

 Epileptic seizures [ICD11: 8A60-8A6Z]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 Rev-erba KO mice

Detailed Description

 Nuclear receptor subfamily 1 group D member 1 (NR1D1) has been reported to activate the transcription of SLC6A11 gene in epileptic seizures condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A11 gene in gastric cancer condition [4]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC6A11 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A11 gene in erythroleukemia condition [5]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC6A11 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC6A11 gene in podocyte condition [6]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC6A11 gene in podocyte condition, which leads to an increased expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A11 gene in HEPG2 condition [3]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC6A11 gene in HEPG2 condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

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        TP53 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A11 gene in stress response condition [7]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC6A11 gene in stress response condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A11 gene in health condition [8]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC6A11 gene in health condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC6A11 gene in epithelial ovarian cancer condition [9]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC6A11 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Sodium- and chloride-dependent GABA transporter 3.
References
1 Dysregulation of REV-ERBalpha impairs GABAergic function and promotes epileptic seizures in preclinical models. Nat Commun. 2021 Feb 22;12(1):1216.
2 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
3 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
4 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
5 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
6 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
7 Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res. 2008;36(11):3639-54.
8 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
9 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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