Drug Transporter (DT) Information

General Information of DT
DT ID DTD0439
Gene Name SLC65A2
Protein Name Niemann-Pick C1-like protein 1
Gene ID
29881
UniProt ID
Q9UHC9
TCDB ID
2.A.6.6.6
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6V3F_A

Identity:76.361%

Minimized Score:-3191.503 kcal/mol

Detail: Structure Info

Synonyms LDLCQ7; NPC1-like intracellular cholesterol transporter 1; NPC11L1; NPC1L1; SLC65A2
DT Family Resistance-Nodulation-Cell Division (RND) Superfamily
Eukaryotic (Putative) Sterol Transporter (EST) Family
Function This transporter is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Endogenous Substrate(s) Lipids
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Niemann-Pick C1-like protein 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Niemann-Pick C1-like protein 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Niemann-Pick C1-like protein 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Niemann-Pick C1-like protein 1
Microbiota Influence (MBI)

(β) Post-translational Modification of Niemann-Pick C1-like protein 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Niemann-Pick C1-like protein 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Niemann-Pick C1-like protein 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Niemann-Pick C1-like protein 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(δ) Xenobiotics-regulated Structural Variability
Xenobiotics-regulated Structural Variability (XSV)

General Variability Data of This DT

(α) Genetic Polymorphisms of Niemann-Pick C1-like protein 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Niemann-Pick C1-like protein 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Cholesterol
 Phase 2 Drug Info Cone-Rod dystrophy 9B70 [1]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Lipoprotein unspecific N.A. EM Info Unclear experiment used for identifying this EM [2]
References
1 Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science. 2004 Feb 20;303(5661):1201-4.
2 Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 Aug 5;466(7307):707-13.

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