Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0439 Transporter Info | |||||
| Gene Name | SLC65A2 | |||||
| Transporter Name | Niemann-Pick C1-like protein 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 6V3F_A | Identity | 76.361% | |||
| Performance | Minimized Score | -3191.503 kcal/mol | ||||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -0.74 ±0.21 | |||||
| Residues in Favored Region | 1299 | Ramachandran favored | 97.23% | |||
| Number of Outliers | 8 | Ramachandran outliers | 0.60% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.78 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 3QNT | X-ray | 2.83 Å | Trichoplusia ni | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 22-284 | Mutation | No | |||
| 7DF8 | EM | 3.03 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 1274 | Mutation | No | |||
| 7DFW | EM | 2.69 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 1288 | Mutation | No | |||
| 7DFZ | EM | 3.58 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 1273 | Mutation | No | |||
| 7N4U | EM | 3.34 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1332 | Mutation | No | |||
| 7N4V | EM | 3.58 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 1332 | Mutation | No | |||
| 7N4X | EM | 3.33 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 1332 | Mutation | Yes | |||
| References | ||||||
| 1 | The structure of the NPC1L1 N-terminal domain in a closed conformation. PLoS One. 2011 Apr 15;6(4):e18722. | |||||
| 2 | Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake. Sci Adv. 2021;7(29). | |||||
| 3 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Sci Adv. 2021;7(34). | |||||
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